포비돈요오드
POVI디NE-요오드 · 포비돈요오드 · 포비딘-요오드 · 포비딘-요오드(POVIDINE-IODINE) · PVP-I · polyvinyl · POLYVINYLPYRROLIDONE IODINE · betadine
식별자 및 물리적 특성
| CAS No. | 25655-41-8 |
|---|---|
| 분자식 | C6H9I2NO |
| 평균 분자량 | 364.95 g/mol |
| SMILES | C=CN1CCCC1=O.II |
| InChIKey | FAAHNQAYWKTLFD-UHFFFAOYSA-N |
| PubChem CID | 410087 |
| ChEMBL | CHEMBL5424182 |
| 현지명 | 포비돈요오드 |
화학 및 물리적 성질
| 극성 표면적 | 20.3 |
|---|---|
| 수소 결합 공여자 수 | 0 |
| 수소 결합 수용자 수 | 1 |
| 회전 가능 결합 수 | 1 |
| 무거운 원자 수 | 10 |
| 형식 전하 | 0 |
| 복잡도 | 120 |
| 녹는점 | 300 °C |
| 저장 조건 | Keep in dark place,Inert atmosphere,Room temperature |
| 용해도 | H2O: 가용성100mg/mL |
| 물리적 상태 | 가루 |
| 색상 | 옐로우 브라운 컬러 |
| 냄새 | ylsh. brn. amorphous powd., sl. char. odor |
| 용해도 | 물, 에틸 알코올, 이소프로필 알코올, 폴리에틸렌 글리콜 및 글리세롤에 용해됩니다. 클로로포름, 사염화탄소, 헥산, 아세톤 및 석유 에테르에 용해되지 않습니다. |
| Merck | 13,7784 |
| 화장품 원료 기능 | 항균 |
| InChI | InChI=1S/C6H9NO.I2/c1-2-7-5-3-4-6(7)81-2/h2H,1,3-5H2 |
| InChIKey | FAAHNQAYWKTLFD-UHFFFAOYSA-N |
| SMILES | II.C(N1CCCC1=O)=C |
| EPA | Povidone-iodine (25655-41-8) |
화학적 성질
Povidone iodine is a complex of iodine with povidone. It occurs as a yellowish brown to reddish brown amorphous powder, having a slight characteristic odour. Its solution is acid to litmus. Soluble in water and in alcohol, practically insoluble in chloroform, in carbon tetrachloride, in ether, in solvent hexane, and in acetone. It is an external antiseptic with a broad microbicidal spectrum against bacteria, fungi, viruses, protozoa, and yeasts. This gel has about 1.0% available iodine.
안전 및 규제
| 수질 위해 등급(WGK) | 2 |
|---|---|
| TSCA 등재 상태 | TSCA listed |
| RTECS 번호 | TR1579600 |
| 관세 코드 | 29339900 |
| 안전 문구(S) | 24/25-22 |
| 기존화학 물질 | KE-13325 |
| 위험 등급 | Aquatic Chronic 2Eye Dam. 1Skin Irrit. 2 |
| 저장 분류 | 11 - Combustible Solids |
| 유해 물질 데이터 | 25655-41-8(Hazardous Substances Data) |
용도
개요
Povidone iodine is iodophor, used as topical antiseptic in surgery and for skin and mucous membrane infections, also as aerosol. A 10% povidone iodine solution contains 1% available iodine, but free-iodine is at 0.1% concentration. Skin exposure causes irritant rather than allergic contact dermatitis. In such a situation, however, iodine seems to be the true hapten.
역사
Povidone iodine (PI) is frequently used during surgical preparation, postoperative wound cleaning and dressing. It was described by Shelaski about seventy years ago (Shelanski and Shelanski, 1956). PI consists of the complex structure of povidone, a polymer that is structurally similar to plasma proteins, and the iodine element, which has antimicrobial properties. The function of polyvinylpyrrolidone (PVP) used as a polymer includes increasing iodine solubility and penetration, decreasing iodine ion concentration and keeping iodine bound. However, PVP does not have antimicrobial properties. Shelanski defined this complex structure as 'iodophor' (Shelanski and Shelanski, 1956).
제조 및 합성 방법
제조 방법
Povidone Iodine Solution is an antiseptic and disinfectant agent. The preparation method of povidone iodine: be that 1.17% potassium iodide is dissolved in part water in 10% water by mass percent, 2.34% iodine is added to wherein stirring and dissolving, be mixed with iodine solution standby; 0.01% stability auxiliary agent is dissolved in part water 10% water standby; In complex reaction still, add remaining water, open and stir, dropping into 10.0% polyvinylpyrrolidone k30 dissolves, then substep adds above-mentioned two kinds of solution that prepare, finally add 7.5% solvent normal propyl alcohol, after feeding intake, allow reactant mixture at 20 ℃, react 2 hours, react complete mixture is lowered the temperature and obtained betagen solution.