기본 정보
- CAS
78967-07-4- 표준 SMILES
COc1ccc(-c2noc(CC(=O)O)c2-c2ccc(OC)cc2)cc1- InChIKey
DJEIHHYCDCTAAH-UHFFFAOYSA-N- 분자식
- C19H17NO5
- 평균 분자량
- 339.3 g/mol
- 단동위원소 질량
- 339.11067264
개요
Mofezolac (TN) is a member of methoxybenzenes.
이름 및 식별자
- 우선 이름
- Mofezolac
- IUPAC
- 2-[3,4-bis(4-methoxyphenyl)-1,2-oxazol-5-yl]acetic acid
- 현지명
- 모페졸락
- 영어명
- Mofezolac
- 분자식
- C19H17NO5
- 분자량
- 339.34
이름 및 동의어
mofezolac78967-07-4MofezolacoMofezolacumDTXSID1046716RVJ0BV3H3YDTXCID9026716(3,4-bis(4-methoxyphenyl)-5-isoxazolyl)acetic acid3,4-DMPIAAN-22 compound[3,4-bis(4-methoxyphenyl)-5-isoxazolyl]acetic acid(3,4-di-(4-methoxyphenyl)-5-isoxazolyl)acetic acid
이름 더 보기
모페졸락Mofezolac, 10 mM in DMSO3,4-Bis(4-methoxyphenyl)isoxazole-5-acetic acid3,4-Bis(4-methoxyphenyl)-5-isoxazoleacetic acidα-[3,4-Bis(4-methoxyphenyl)-5-isoxazolyl]acetic acid
RefChem:159308Disopain2-(3,4-bis(4-methoxyphenyl)isoxazol-5-yl)acetic acidMofezolac [INN]N-222-[3,4-bis(4-methoxyphenyl)-1,2-oxazol-5-yl]acetic acid5-Isoxazoleacetic acid, 3,4-bis(4-methoxyphenyl)-Mofezolac (TN)
데이터베이스 식별자
- CAS
78967-07-4- PubChem CID
- 4237
- DTXSID
DTXSID1046716- ChEMBL
CHEMBL259972- ChEBI
CHEBI:31860
물성
구조 계산 물성
- XLogP
- 3.1
- 극성 표면적
- 81.8 Ų
- 수소 결합 공여자 수
- 1
- 수소 결합 수용자 수
- 6
- 회전 가능 결합 수
- 6
- 무거운 원자 수
- 25
- 형식 전하
- 0
- 복잡도
- 430
물리화학적 성질
- 녹는점
- 147.5 ℃ · 147.5℃
- 끓는 점
- 527.2 · 527.2±50.0 °C(Predicted)
- 밀도
- 1.25 · 1.250±0.06 g/cm3(Predicted)
- 저장 조건
- 2 · 2-8°C
- 용해도
- DMSO: 용해될 수 있다
- 물리적 상태
- 고체
- 산도 계수 (pKa)
- 3.3 · pKa ~3.3(at 25℃)
- 색상
- White to off-white
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
안전 데이터
- 독성
- LD50 in male, female mice, male, female rats (mg/kg): 1528, 1740, 920, 887 orally; 275, 321, 378, 342 i.p.; 612, 545, 572, 510 s.c. (Satoh)
화학 및 산업
약리 정보
MeSH Pharmacological ClassificationCompounds or agents that combine with cyclooxygenase (PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES) and thereby prevent its substrate-enzyme combination with arachidonic acid and the formation of eicosanoids, prostaglandins, and thromboxanes.
응용 분야
개요Mofezolac is a new non-steroidal analgesic antiinflammatory agent introduced in Japan for the treatment of post-operative and post-traumatic pain, acute upper respiratory tract pain, osteoarthritis, and lumbago. In in vfim studies, mofezolac inhibits prostaglandin biosynthesis and platelet aggregation, reportedly through the inhibition of cyclooxygenase. In animal studies, mofezolac showed more potent suppression in various writhing models than agents such as ibuprofen, mefenamic acid and aspirin. Mofezolac also has a potent inhibitory activity on the algesic responses induced by the mechanical stimulus of the inflamed tissue. The ulcerogenic effect of mofezolac on the gastric mucosa is far weaker than that of indomethacin and other agents.
공급사40 곳
陕西缔都医药有限责任公司029-81124775 17791530730 · [email protected]
Career Henan Chemica Co+86-0371-86658258 +86-13203830695 · [email protected]
成都超九八生物科技有限公司13348960310 13348960310 · [email protected]
上海麦克林生化科技股份有限公司021-50706066 15221275939 · [email protected]
上海毕得医药科技股份有限公司400-1647117 13681763483 · [email protected]
杭州摩库生物医药科技有限公司+86-057181025280; +8617767106207 · [email protected]
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