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댄실카다베린

Monodansylcadaverine

HCID 4247
노트반응
기본 정보개요이름 및 식별자물성안전 및 규제화학 및 산업관련 반응화합물 노트
부분 구조 검색유사 구조 찾기

기본 정보

CAS
10121-91-2
표준 SMILES
CN(C)c1cccc2c(S(=O)(=O)NCCCCCN)cccc12
InChIKey
MLEBFEHOJICQQS-UHFFFAOYSA-N
분자식
C17H25N3O2S
평균 분자량
335.5 g/mol
단동위원소 질량
335.16674822

개요

Monodansylcadaverine is a sulfonamide obtained by formal condensation of the sulfo group of 5-(dimethylamino)naphthalene-1-sulfonic acid with one of the amino groups of cadaverine. It has a role as a protective agent, a fluorochrome and an EC 2.3.2.13 (protein-glutamine gamma-glutamyltransferase) inhibitor. It is a sulfonamide, an aminonaphthalene, a primary amino compound and a tertiary amino compound. It is functionally related to a cadaverine.

이름 및 식별자

우선 이름
Monodansylcadaverine
IUPAC
N-(5-aminopentyl)-5-(dimethylamino)naphthalene-1-sulfonamide
현지명
댄실카다베린
영어명
DANSYLCADAVERINE
분자식
C17H25N3O2S
분자량
335.46

이름 및 동의어

Dansylcadaverine10121-91-2monodansylcadaverine1-Naphthalenesulfonamide, N-(5-aminopentyl)-5-(dimethylamino)-I9N81SC5HDDTXSID40143788N-(5-Aminopentyl)-5-dimethylamino-1-naphthalenesulfonamideCHEBI:52007RefChem:159553DTXCID7066279233-326-9n-(5-aminopentyl)-5-(dimethylamino)naphthalene-1-sulfonamide
이름 더 보기
댄실카다베린5-<WBRDansylcadaverine, 10 mM in DMSOMONODANSYLCADAVERINE CRYSTALLINEDANSYLCADAVERINE, FOR FLUORESCENCEDANSYLCADAVERINE MONODANSYLCADAVERINEN-(DIMETHYL-AMINO-NAPHTHA-LENE-SULFONYL)-1
Monodansyl cadaverineMFCD00042704EINECS 233-326-9N-(5-Aminopentyl)-5-(dimethylamino)naphthalene-1-sulphonamideUNII-I9N81SC5HDMLEBFEHOJICQQS-UHFFFAOYSA-NN-(5-Aminopentyl)-5-(dimethylamino)-1-naphthalenesulfonamide; Dansylcadaverine; Monodansylcadaverine;N-monodansylcadaverine

데이터베이스 식별자

CAS

물성

구조 계산 물성

XLogP
2.5
극성 표면적
83.8 Ų
수소 결합 공여자 수
2
수소 결합 수용자 수
5
회전 가능 결합 수
8
무거운 원자 수
23
형식 전하
0
복잡도
447

물리화학적 성질

녹는점
137 · 137-140 °C
끓는 점
505.5 · 505.5±60.0 °C(Predicted)
밀도
1.19 · 1.190±0.06 g/cm3(Predicted)
저장 조건
20 °C · −20°C
용해도
10 mg/ml · Methanol: 10 mg/ml
물리적 상태
가루
산도 계수 (pKa)
11.96 · 11.96±0.50(Predicted)
색상
노란색에서 황록색
BRN
2951070 · 2951070
안정성
1 · 제공된 대로 구매일로부터 1년 동안 안정적입니다. DMSO 또는 메탄올 용액은 -20°C에서 최대 1개월 동안 보관할 수 있습니다.
InChI
1S/C17H25N3O2S/c1-20(2)16-10-6-9-15-14(16)8-7-11-17(15)23(21,22)19-13-5-3-4-12-18/h6-11,19H,3-5,12-13,18H2,1-2H3
InChIKey
MLEBFEHOJICQQS-UHFFFAOYSA-N
SMILES
CN(C)c1cccc2c(cccc12)S(=O)(=O)NCCCCCN

안전 및 규제

안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.

GHS 분류

GHS Classification · 4건

Warning

H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]

P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 39 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

유해성 정보

Regulatory Information1-Naphthalenesulfonamide, N-(5-aminopentyl)-5-(dimethylamino)-: Does not have an individual approval but may be used under an appropriate group standard
Hazard Classes and CategoriesSkin Irrit. 2 (100%)

안전 데이터

wgk
3
risk_code
36/37/38
hazard_code
Xi
safety_code
26-36
F 고인화성물질
10-23
Hazard Classifications
Eye Irrit. 2Skin Irrit. 2STOT SE 3
스토리지 클래스
11 - Combustible Solids

화학 및 산업

약리 정보

MeSH Pharmacological Classification · 4건

Substances that inhibit or prevent the proliferation of NEOPLASMS.

Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.

Chemicals that emit light after excitation by light. The wave length of the emitted light is usually longer than that of the incident light. Fluorochromes are substances that cause fluorescence in other substances, i.e., dyes used to mark or label other compounds with fluorescent tags.

Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.

응용 분야 · 2건

개요Monodansylcadaverine (MDC) is a fluorescent marker for autophagic vacuoles. It is an autofluorescent substance incorporated into multilamellar bodies by both an ion trapping mechanism and interaction with membrane lipids, exhibiting a Stokes shift and increased relative fluorescence in hydrophobic environments. MDC selectively accumulates in PaTu 8902 subcellular fractions containing the lysosomal enzymes acid phosphatase and cathepsin D, but not those containing the rough and smooth endoplasmic reticulum markers TRAM and cytochrome P450, respectively.

용도Dansylcadaverine is a fluorescent amine probe, which is believed to directly inhibit vesicular transport. Studies indicate that Dansylcadaverine can act as a marker used to study autophagy in the cytoplasm and vacuoles of plants and mammalian cells.

공급사66 곳

苏州道澜生物医药科技有限公司15952404857 · [email protected]
上海阿拉丁生化科技股份有限公司

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10121-91-2
PubChem CID
4247
DTXSID
DTXSID40143788
ChEMBL
CHEMBL5422910
ChEBI
CHEBI:52007
UNII
I9N81SC5HD
EC Number
233-326-9
Nikkaji
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