비코자마이신

6-Hydroxy-5-methylene-1-(1,2,3-trihydroxy-2-methylpropyl)-2-oxa-7,9-diazabicyclo[4.2.2]decane-8,10-dione

HCID 426058

노트 반응

부분 구조 검색 유사 구조 찾기

기본 정보

CAS: 38129-37-2
표준 SMILES: C=C1CCOC2(C(O)C(C)(O)CO)NC(=O)C1(O)NC2=O
InChIKey: WOUDXEYYJPOSNE-UHFFFAOYSA-N
분자식: C12H18N2O7
평균 분자량: 302.28 g/mol

이름 및 식별자

우선 이름: 6-Hydroxy-5-methylene-1-(1,2,3-trihydroxy-2-methylpropyl)-2-oxa-7,9-diazabicyclo[4.2.2]decane-8,10-dione
IUPAC: 6-hydroxy-5-methylidene-1-(1,2,3-trihydroxy-2-methylpropyl)-2-oxa-7,9-diazabicyclo[4.2.2]decane-8,10-dione
현지명: 비코자마이신
영어명: bicozamycin
분자식: C12H18N2O7
분자량: 302.28

이름 및 동의어

CGP 3543/ENSC1805166-Hydroxy-5-methylene-1-(1,2,3-trihydroxy-2-methylpropyl)-2-oxa-7,9-diazabicyclo[4.2.2]decane-8,10-dioneCHEMBL1976371SCHEMBL11210643(1R,6R)-6-Hydroxy-5-methylidene-1-[(1S,2S)-1,2,3-trihydroxy-2-methylpropyl]-2-oxa-7,9-diazabicyclo[4.2.2]decane-8,10-dione6-hydroxy-5-methylidene-1-(1,2,3-trihydroxy-2-methylpropyl)-2-oxa-7,9-diazabicyclo[4.2.2]decane-8,10-dione1-hydroxy-2-methylene-6-(1,2,3-trihydroxy-2-methyl-propyl)-5-oxa-8,10-diazabicyclo[4.2.2]decane-7,9-dione비코자마이신C11259WS-4545ICOZAMYCIN

이름 더 보기

bicozamycinBicycloMycinBicozaMycin benzoateBicozaMycin, AizuMycin, Bacteron, CGP 3543E, WS4545, 5879(1R,6S)-1-hydroxy-2-methylidene-6-[(1S,2S)-1,2,3-trihydroxy-2-methylpropyl]-5-oxa-8,10-diazabicyclo[4.2.2]decane-7,9-dione2-Oxa-7,9-diazabicyclo[4.2.2]decane-8,10-dione, 6-hydroxy-5-methylene-1-[(1S,2S)-1,2,3-trihydroxy-2-methylpropyl]-, (1S,6R)-

데이터베이스 식별자

CAS: 38129-37-2
PubChem CID: 426058
ChEMBL: CHEMBL1976371

물성

구조 계산 물성

XLogP: -2.9
극성 표면적: 148 Å²
수소 결합 공여자 수: 6
수소 결합 수용자 수: 7
회전 가능 결합 수: 3
무거운 원자 수: 21
형식 전하: 0
복잡도: 510

물리화학적 성질

녹는점: 188 · 188-191° (dec); mp 187-189° (dec) (Imanaka); mp 166-170° (Nakatsuka et al.)
끓는 점: 786.6 · 786.6±60.0 °C(Predicted)
밀도: 1.57 · 1.57±0.1 g/cm3(Predicted)
산도 계수 (pKa): 9.85 · 9.85±0.60(Predicted)

안전 및 규제

안전 데이터

독성: LD50 in mice: >4 g/kg (Williams, Durham)

화학 및 산업

응용 분야 · 1건

용도Bicyclomycin is a polar metabolite first isolated from Streptomyces sapporonensis in 1972. The selective Gram negative profile of bicyclomycin is rare among Streptomyces metabolites. The primary site of action for bicyclomycin is thought to be the rho transcription termination factor.

공급사17 곳

浙江珲达生物科技有限公司0571-89903022 18679456698 · [email protected]

上海赛可锐生物科技有限公司021-58000709 13120558703 · [email protected]

安耐吉化学&3A（安徽泽升科技有限公司）021-58432009 400-005-6266 · [email protected]

孟成科技（上海）有限公司400-820-6829 · [email protected]

上海维亦特生物科技有限公司15317051735 · [email protected]

추가 설명

정의ChEBI: A commercially important azabicyclic antibiotic obtained from Streptomyces sapporonensis. It inhibits the Rho protein of E. coli.

화합물 노트

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