기본 정보
- CAS
127502-06-1- 표준 SMILES
CCOCCP(CCOCC)CCP(CCOCC)CCOCC- InChIKey
QCWJONLQSHEGEJ-UHFFFAOYSA-N- 분자식
- C18H40O4P2
- 평균 분자량
- 382.5 g/mol
- 단동위원소 질량
- 382.24018375
개요
Tetrofosmin is a phosphine.
이름 및 식별자
- 우선 이름
- Tetrofosmin
- IUPAC
- 2-[bis(2-ethoxyethyl)phosphanyl]ethyl-bis(2-ethoxyethyl)phosphane
- 현지명
- 테트로포스민
- 영어명
- Tetrofosmin
- 분자식
- C18H40O4P2
- 분자량
- 382.46
이름 및 동의어
TetrofosminUNII-3J0KPB596QtetrofosmineTetrofosmina3J0KPB596QP 53P-53DTXSID70155591TETROFOSMIN (II)TETROFOSMIN [II]tetrofosminumRefChem:58134
이름 더 보기
테트로포스민Myoview
DTXCID5078082V09GA02127502-06-1ethylenebis[bis(2-ethoxyethyl)phosphine]2-[bis(2-ethoxyethyl)phosphanyl]ethyl-bis(2-ethoxyethyl)phosphane3,12-Dioxa-6,9-diphosphatetradecane, 6,9-bis(2-ethoxyethyl)-Tetrofosmin [USAN:INN:BAN:JAN]6,9-bis(2-ethoxyethyl)-3,12-dioxa-6,9-diphosphatetradecane
데이터베이스 식별자
- CAS
127502-06-1- PubChem CID
- 4274
- DTXSID
DTXSID70155591- ChEMBL
CHEMBL1615784- ChEBI
CHEBI:135598- UNII
- 3J0KPB596Q
- Nikkaji
- J506.542I
물성
구조 계산 물성
- XLogP
- 0.5
- 극성 표면적
- 36.9 Ų
- 수소 결합 공여자 수
- 0
- 수소 결합 수용자 수
- 4
- 회전 가능 결합 수
- 19
- 무거운 원자 수
- 24
- 형식 전하
- 0
- 복잡도
- 201
실험 및 물리화학적 성질
DrugsPharmaceuticals -> Listed in ZINC15
SolubilitySoluble
Boiling Point100ºC
물리화학적 성질
- 끓는 점
- 447.1 · 447.1±45.0 °C(Predicted)
화학 및 산업
약리 정보
Protein BindingRefer to [DB09160]
PharmacodynamicsRefer to [DB09160]
Mechanism of Action
Tetrofosmin normal biodistribution makes it suitable to be used as a myocardial agent as it is uptaken by the myocardial tissue and it presents a very low redistribution after 3-4 hours of administration. After distribution, tetrofosmin is a lipophilic cationic agent which is passively diffused and accumulated in viable myocardial tissue.
Biological Half-LifeRefer to [DB09160]
Metabolism/MetabolitesThis pharmacokinetic property has not been fully studied.
Absorption, Distribution and Excretion
After intravenous administration, tetrofosmin is rapidly cleared from the blood and taken up by the heart, skeletal muscle, liver, spleen and kidneys.
Refer to [DB09160]
This pharmacokinetic property has not been fully studied.
Refer to [DB09160]
응용 분야
용도Tetrofosmin is used in diagnostic imaging procedures. A dual tracer imager for patients with hyperparathyroidism. A radiotracers for SPECT imaging.
공급사4 곳
Alfa Chemistry1-516-6625404 · [email protected]
Alfa Chemistry+1-5166625404 · [email protected]
上海陶术生物科技股份有限公司+1-781-999-5354 · [email protected]
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