에고마케톤

A REVIEW WITH 26 REFERENCES ON THE PULMONARY TOXICITY OF NATURALLY OCCURRING 3-SUBSTITUTED FURANS, INCLUDING THE PERILLA FRUTESCENS LUNG TOXIN EGOMAKETONE.[WILSON BJ ET AL; PULMONARY TOXICITY OF NATURALLY OCCURRING 3-SUBSTITUTED FURANS; EFF POISONOUS PLANTS LIVEST (PROC JT US AUST SYMP POISONOUS PLANTS) 311 (1978)]

TOXICITY STUDIES INDICATE THAT PERILLA KETONE, EGOMAKETONE, & ISOEGOMAKETONE ARE APPROXIMATELY EQUAL IN IP LD50 VALUES & PRODUCE IDENTICAL PULMONARY EFFECTS IN LABORATORY MICE. GROSS PULMONARY LESIONS ARE INDISTINGUISHABLE FROM THE DISEASE CAUSED BY 4-IPOMEANOL; HOWEVER, UNLIKE 4-IPOMEANOL, PERILLA KETONE DOES NOT AFFECT THE KIDNEYS OF ADULT MALE MICE. /PERILLA KETONE/

INJECTIONS OF 3 & 9 MG/KG, RESPECTIVELY, OF PERILLA KETONE DIRECTLY INTO THE RUMEN ELICITED NO RESPONSE IN ANGUS HEIFERS. ANOTHER HEIFER RECEIVING 30 MG/KG IV, HOWEVER, DEVELOPED SEVERE RESPIRATORY DISTRESS BEGINING WITHIN 10 HR & DIED ON THE THIRD DAY AFTER INJECTION. EXTENSIVE PLEURAL EFFUSION WAS PRESENT TOGETHER WITH OTHER PULMONARY DISEASE SIGNS. ANOTHER ANIMAL RECEIVING 40 MG/KG PER OS WAS UNAFFECTED. /PERILLA KETONE/

AN ADULT MALE SHEEP RECEIVING 19 MG/KG OF PERILLA KETONE IV DEVELOPED RESPIRATORY DISTRESS ON DAY 3 BUT HAD IMPROVED SOMEWHAT BY THE FIFTH DAY POSTINJECTION, WHEN IT WAS SACRIFICED. THE LUNGS, AS PRIMARY TARGETS OF THE TOXIN, SHOWED FOCAL CAPILLARY CONGESTION & INTRAALVEOLAR EDEMA. TWO FEMALE GOATS INJECTED IV WITH 18 & 40 MG/KG, RESPECTIVELY, DIED WITHIN 12 HR WITH SEVERE PULMONARY EDEMA. A DOSE OF 10 MG/KG, IV KILLED ANOTHER FEMALE GOAT IN 36 HR. A DOSE OF 150 MG/KG INJECTED INTO THE RUMEN OF A GOAT RESULTED IN DEATH OF THE RECIPIENT IN 48 HR. /PERILLA KETONE/

Essential oil of perilla frutescene; Used for food flavoring, in soyo folk medicine, and in biochemical and physiological studies; [HSDB]

FOOD FLAVORING; IN "SOYO" FOLK MEDICINE; IN BIOCHEMICAL & PHYSIOLOGICAL STUDIES /ESSENTIAL OIL OF PERILLA FRUTESCENS/