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기본 정보
- CAS
202463-68-1- 표준 SMILES
Cc1c(C(=O)NN2CCOCC2)nn(-c2ccc(Cl)cc2Cl)c1-c1ccc(I)cc1- InChIKey
AJFFBPZYXRNAIC-UHFFFAOYSA-N- 분자식
- C21H19Cl2IN4O2
- 평균 분자량
- 557.219 g/mol
- 단동위원소 질량
- 555.99297921
이름 및 식별자
- 우선 이름
- 1-(2,4-Dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-4-morpholinyl-1H-pyrazole-3-carboxamide
- IUPAC
- 1-(2,4-Dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-(morpholin-4-yl)-1H-pyrazole-3-carboxamide
- 영어명
- 1-(2,4-Dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-4-morpholinyl-1H-pyrazole-3-carboxamide
- 분자식
- C21H19Cl2IN4O2
- 분자량
- 557.21
이름 및 동의어
AM 281CS-1127AM-281 ,99%AM281AM-281AM281, 10 mM in DMSO1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-morpholino-1H-pyrazole-3-carboxamide1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-morpholin-4-ylpyrazole-3-carboxamide1-(2,4-Dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-4-morpholinyl-1H-pyrazole-3-carboxamide1H-Pyrazole-3-carboxamide,1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-4-morpholinyl-inhibit,Inhibitor,neurotoxicity,SH-SY5Y,CB1,Cannabinoid Receptor,memory,AM281,AM-281,AM 281
데이터베이스 식별자
- CAS
202463-68-1- PubChem CID
- 4302962
- DTXSID
DTXSID601122269- ChEMBL
CHEMBL476833- ChEBI
CHEBI:93039- UNII
- SBP4A4DYH2
- EC Number
- 633-840-7
- Nikkaji
- J1.084.250F
물성
물리화학적 성질
- 밀도
- 1.7 · 1.70±0.1 g/cm3(Predicted)
- 저장 조건
- 2 · 2-8°C
- 용해도
- 6 mg/mL · DMSO: >6mg/mL
- 물리적 상태
- 고체
- 산도 계수 (pKa)
- 10.76 · 10.76±0.20(Predicted)
- 색상
- 하얀색
- InChI
- 1S/C21H19Cl2IN4O2/c1-13-19(21(29)26-27-8-10-30-11-9-27)25-28(18-7-4-15(22)12-17(18)23)20(13)14-2-5-16(24)6-3-14/h2-7,12H,8-11H2,1H3,(H,26,29)
- InChIKey
- AJFFBPZYXRNAIC-UHFFFAOYSA-N
- SMILES
- Cc1c(nn(-c2ccc(Cl)cc2Cl)c1-c3ccc(I)cc3)C(=O)NN4CCOCC4
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
안전 데이터
- wgk
- 3
- ridadr
- UN 2811 6.1/PG 3
- risk_code
- 25-36/37/38
- hazard_code
- T
- safety_code
- 26-36/37/39-45
- Hazard Classifications
- Acute Tox. 2 OralEye Irrit. 2Skin Irrit. 2STOT SE 3
- 스토리지 클래스
- 6.1A - Combustible acute toxic Cat. 1 and 2very toxic hazardous materials
화학 및 산업
응용 분야
개요AM281 is a potent and selective central cannabinoid (CB1) receptor antagonist/inverse agonist (Kis = 12 nM and 4,200 nM for CB1 and CB2, respectively). Structurally, it is an analog of the CB1 inverse agonist rimonabant . It has no effect on the vanilloid TRPV1 receptor. AM281 has been used to evaluate the potential effects of compounds at CB1. It has also been used to study the membrane localization and cycling of CB1.
용도AM 281 acts as a potential CB1 selective receptor cannabinoid antagonist.
공급사43 곳
阿诺西（上海）生物技术有限公司400-1107768 15058188853 · [email protected]
武汉英诺医药科技有限公司+86-027-59232304 15387063101 · [email protected]
成都超九八生物科技有限公司13348960310 13348960310 · [email protected]
苏州景皓生物科技有限公司18136139868; 18136139868 · [email protected]
湖北科乐精细化工有限公司027-59101668 19945030958 · [email protected]
武汉易泰科技有限公司上海分公司18930552037 · [email protected]
欧利希（湖北）医药科技有限公司17316404525 17316404525 · [email protected]
北京博奥森生物技术有限公司400-901-9800 18611424007 · [email protected]
学研惠（武汉）科技有限公司15727060112 · [email protected]
VDM Biochemicals0330-2528181 · [email protected]
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