기본 정보
- CAS
58-82-2- 표준 SMILES
NC(N)=NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(=O)O- InChIKey
QXZGBUJJYSLZLT-FDISYFBBSA-N- 분자식
- C50H73N15O11
- 평균 분자량
- 1,060.2 g/mol
- 단동위원소 질량
- 1,059.5613982
개요
Bradykinin is a linear nonapeptide messenger belonging to the kinin group of proteins, with amino acid sequence RPPGFSPFR. Enzymatically produced from kallidin in the blood, it is a powerful vasodilator that causes smooth muscle contraction, and may mediate inflammation. It has a role as a vasodilator agent and a human blood serum metabolite. It is a conjugate base of a bradykinin(2+).
이름 및 식별자
- 우선 이름
- Bradykinin
- IUPAC
- (2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[2-[[(2S)-1-[(2S)-1-[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carbonyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]pyrrolidine-2-carbonyl]amino]-3-phenylpropanoyl]amino]-5-(diaminomethylideneamino)pentanoic acid
- 현지명
- 브라디키닌
- 영어명
- BRADYKININ
- 분자식
- C50H73N15O11
- 분자량
- 1060.21
이름 및 동의어
BRADYKININ58-82-2L-BradykininKallidin ICallidin IKallidin-9(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[2-[[(2S)-1-[(2S)-1-[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carbonyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]pyrrolidine-2-carbonyl]amino]-3-phenylpropanoyl]amino]-5-(diaminomethylideneamino)pentanoic acidBRS-640S8TIM42R2WCHEBI:3165DTXSID50893681Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg
이름 더 보기
브라디키닌bkbrs640prs640C00306RPPGFSPFRBRADYZIDECallideicKallidinⅠ
(2S)-2-(((2S)-2-(((2S)-1-((2S)-2-(((2S)-2-((2-(((2S)-1-((2S)-1-((2S)-2-amino-5-(diaminomethylideneamino)pentanoyl)pyrrolidine-2-carbonyl)pyrrolidine-2-carbonyl)amino)acetyl)amino)-3-phenylpropanoyl)amino)-3-hydroxypropanoyl)pyrrolidine-2-carbonyl)amino)-3-phenylpropanoyl)amino)-5-(diaminomethylideneamino)pentanoic acid(2S)-2-((2S)-2-(((2S)-1-((2S)-2-((2S)-2-(2-(((2S)-1-(((2S)-1-((2S)-2-amino-5-carbamimidamidopentanoyl)pyrrolidin-2-yl)carbonyl)pyrrolidin-2-yl)formamido)acetamido)-3-phenylpropanamido)-3-hydroxypropanoyl)pyrrolidin-2-yl)formamido)-3-phenylpropanamido)-5-carbamimidamidopentanoic acid(2S)-2-[(2S)-2-{[(2S)-1-[(2S)-2-[(2S)-2-(2-{[(2S)-1-{[(2S)-1-[(2S)-2-amino-5-carbamimidamidopentanoyl]pyrrolidin-2-yl]carbonyl}pyrrolidin-2-yl]formamido}acetamido)-3-phenylpropanamido]-3-hydroxypropanoyl]pyrrolidin-2-yl]formamido}-3-phenylpropanamido]-5-carbamimidamidopentanoic acidRefChem:388840DTXCID501323800Arg Pro Pro Gly Phe Ser Pro Phe Arg200-398-8Synthetic bradykinin
물성
구조 계산 물성
- XLogP
- -4.8
- 극성 표면적
- 419 Ų
- 수소 결합 공여자 수
- 12
- 수소 결합 수용자 수
- 14
- 회전 가능 결합 수
- 27
- 무거운 원자 수
- 76
- 형식 전하
- 0
- 복잡도
- 2,080
실험 및 물리화학적 성질
Physical DescriptionSolid
Collision Cross Section
343.33 Ų [M+2H]2+ [CCS Type: DT; Method: stepped-field]
314.6 Ų [M+H]+
물리화학적 성질
- 녹는점
- 170 °C · 170°C (rough estimate)
- 끓는 점
- 811.85 °C · 811.85°C (rough estimate)
- 밀도
- 1.1171 · 1.1171 (rough estimate)
- 굴절률
- 1.693 · 1.6930 (estimate)
- 저장 조건
- 20 °C · −20°C
- 용해도
- 2 O: · H2O: >40 mg/mL
- 물리적 상태
- 백색 내지 황백색의 동결건조된 고체
- 산도 계수 (pKa)
- 3.34 · 3.34±0.10(Predicted)
- 색상
- Lyophilized powder
- 수용성
- 1 mg/ml까지 · 물에 1mg/ml까지 용해됩니다.
- InChIKey
- QXZGBUJJYSLZLT-FDISYFBBSA-N
화학적 성질
Amorphous solid.
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
안전 데이터
- wgk
- 3
- safety_code
- 22-24/25
- F 고인화성물질
- 3-10-23
- 스토리지 클래스
- 11 - Combustible Solids
화학 및 산업
약리 정보
MeSH Pharmacological ClassificationDrugs used to cause dilation of the blood vessels.
Tissue LocationsProstate
응용 분야
용도Bradykinin is used to lower blood pressure, increase bradykinin (by inhibiting its degradation) further lowering blood pressure. Bradykinin dilates blood vessels via the release of prostacyclin, nitric oxide, and endothelium-derived hyperpolarizing factor.
일반 설명Induces the release of nitric oxide. Other physiological functions include stimulation of pain receptors, inhibition of cAMP accumulation, induction of smooth muscle contraction, and vasodilation. Also involved in edema resulting from trauma or injury. Improves post-ischemic recovery of heart via a nitric oxide-dependent mechanism.
공급사72 곳
成都超九八生物科技有限公司13348960310 13348960310 · [email protected]
上海钰博生物科技有限公司021-60514606 18321282235 · [email protected]
上海毕得医药科技股份有限公司400-1647117 13681763483 · [email protected]
Hangzhou Go Top Peptide Biotech0571-88211921 · [email protected]
济南金邦环保科技有限公司13127153349 · [email protected]
上海鸿肽生物科技有限公司15318089928 · [email protected]
武汉易泰科技有限公司上海分公司18930552037 · [email protected]
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