기본 정보
- CAS
53179-09-2- 표준 SMILES
CN[C@@H]1[C@@H](O)[C@@H](O[C@@H]2[C@@H](O)[C@H](O[C@H]3OC(CN)=CC[C@H]3N)[C@@H](N)C[C@H]2N)OC[C@]1(C)O.CN[C@@H]1[C@@H](O)[C@@H](O[C@@H]2[C@@H](O)[C@H](O[C@H]3OC(CN)=CC[C@H]3N)[C@@H](N)C[C@H]2N)OC[C@]1(C)O.O=S(=O)(O)O.O=S(=O)(O)O.O=S(=O)(O)O.O=S(=O)(O)O.O=S(=O)(O)O- InChIKey
CIKNYWFPGZCHDL-ZHFUJENKSA-N- 분자식
- C38H84N10O34S5
- 평균 분자량
- 1,385.5 g/mol
- 단동위원소 질량
- 1,384.3754956
개요
Sisomicin Sulfate is the sulfate salt form of sisomicin, a broad-spectrum aminoglycoside antibiotic isolated from Micromonospora inyoensis. Sisomicin is strucurally similar to gentamicin but has a unique unsaturated diamino sugar. Of the aminoglycoside antibiotics, sisomicin has the greatest activity against gram-positive bacteria.
이름 및 식별자
- 우선 이름
- Sisomicin Sulfate
- IUPAC
- bis((2R,3R,4R,5R)-2-[(1S,2S,3R,4S,6R)-4,6-diamino-3-[[(2S,3R)-3-amino-6-(aminomethyl)-3,4-dihydro-2H-pyran-2-yl]oxy]-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol);sulfuric acid
- 영어명
- Sisomycin Sulfate
- 분자식
- C19H39N5O11S
- 분자량
- 545.61
이름 및 동의어
Sisomicin sulfate53179-09-2Sch 13475 sulfateSisomicin SulphateSissomicin sulfateSch 13475 sulphateSCH-13475 SulfateK14444371CNSC-757315Sisomicin Sulfate (2:5) SaltD-Streptamine, (2S-cis)-4-O-(3-amino-6-(aminomethyl)-3,4-dihydro-2H-pyran-2-yl)-2-deoxy-6-O-(3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranosyl)-, sulfate (2:5) (salt)O-3-Deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranosyl-(1-4)-O-(2,6-diamino-2,3,4,6-tetradeoxy-alpha-D-glycero-hex-4-enopyranosyl-(1-6))-2-deoxy-L-streptamine sulfate (2:5) (salt)
이름 더 보기
6)-o-(2,6-diamino-2,3,4,6-tetradeoxy-alpha-d-glycero-hex-4-enopyranosyl-(1-4))sisominBaymicinSisollineextramycinpathomycinSisobioticsisomycinsulfate
DTXCID7025479RefChem:886368DTXSID9045479Sisomycin sulfateSisomicin sulfate saltBaymicineMensisoDisisomicin pentakis(sulphate)
물성
구조 계산 물성
- 극성 표면적
- 842 Ų
- 수소 결합 공여자 수
- 26
- 수소 결합 수용자 수
- 44
- 회전 가능 결합 수
- 12
- 무거운 원자 수
- 87
- 형식 전하
- 0
- 복잡도
- 724
물리화학적 성질
- 녹는점
- 70 · 70-73C
- 끓는 점
- 155 ℃ · 155℃
- 인화점
- 110 ° · >110°(230°F)
- 저장 조건
- 2 · Keep in dark place,Inert atmosphere,2-8°C
- 용해도
- 2 O: · H2O: 용해성50mg/mL
- 물리적 상태
- 가루
- 색상
- 흰색에서 황백색까지
- 수용성
- 물에 용해됨
- Merck
- 14 · 14,8550
- 안정성
- 흡습성
- 주요 응용
- 의약품(소분자)
- InChIKey
- JVTNJDPXUPRGIE-QNJHHENCNA-N
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
GHS 분류
GHS Classification
Danger
H312 (97.6%): Harmful in contact with skin [Warning Acute toxicity, dermal]
P203, P261, P271, P280, P302+P352, P304+P340, P317, P318, P321, P362+P364, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 41 reports by companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
유해성 정보
Hazard Classes and CategoriesAcute Tox. 4 (97.6%)
안전 데이터
- wgk
- 3
- rtecs
- WK2288000
- 독성
- LD50 in mice (mg/kg): 34 i.v., 221 i.p., 288 s.c. (Weinstein)
- HS 번호
- 2941901010
- risk_code
- 61-20/21/22-36/37/38
- hazard_code
- T,Xi
- safety_code
- 53-22-36/37/39-45-36-26
- Hazard Classifications
- Acute Tox. 4 DermalAcute Tox. 4 InhalationRepr. 1B
- 스토리지 클래스
- 6.1C - Combustible acute toxic Cat.3toxic compounds or compounds which causing chronic effects
화학 및 산업
약리 정보
MeSH Pharmacological Classification
Compounds which inhibit the synthesis of proteins. They are usually ANTI-BACTERIAL AGENTS or toxins. Mechanism of the action of inhibition includes the interruption of peptide-chain elongation, the blocking the A site of ribosomes, the misreading of the genetic code or the prevention of the attachment of oligosaccharide side chains to glycoproteins.
Substances that inhibit the growth or reproduction of BACTERIA.
응용 분야
용도antibacterial, binds to ribosomes
상·하류 제품 정보
상류 원료
공급사100 곳
国药集团化学试剂有限公司86-21-63210123 · [email protected]
北京华美互利生物化工010-56205725 · [email protected]
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
南通飞宇生物科技有限公司0513-68819626 15152877458 · [email protected]
湖北威德利化学试剂有限公司186-02735115 18062128043 · [email protected]
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