.beta.-D-갈락토피라노스
beta-D-Galactopyranose
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기본 정보
- CAS
7296-64-2- 표준 SMILES
OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@H]1O- InChIKey
WQZGKKKJIJFFOK-FPRJBGLDSA-N- 분자식
- C6H12O6
- 평균 분자량
- 180.16 g/mol
- 단동위원소 질량
- 180.0633881
개요
Beta-D-galactose is a D-galactopyranose having beta configuration at the anomeric centre. It has a role as an epitope and a mouse metabolite. It is an enantiomer of a beta-L-galactose.
이름 및 식별자
- 우선 이름
- beta-D-Galactopyranose
- IUPAC
- (2R,3R,4S,5R,6R)-6-(hydroxymethyl)oxane-2,3,4,5-tetrol
- 현지명
- .beta.-D-갈락토피라노스
- 영어명
- .beta.-D-Galactopyranose
- 분자식
- C6H12O6
- 분자량
- 180.16
이름 및 동의어
beta-D-galactosebeta-D-galactopyranose7296-64-2beta-Galactose(2R,3R,4S,5R,6R)-6-(hydroxymethyl)oxane-2,3,4,5-tetrolRQ6K52J67ACHEBI:27667GlyTouCan:G65889KEDTXSID001015884RefChem:6900DTXCID701474039G65889KE
이름 더 보기
.beta.-D-갈락토피라노스β-D-Galactoseβ-D-galactopyranose-β-D-Galactose.beta.-D-Galactopyranose(2R,3R,4S,5S,6R)-6-(hydroxymethyl)oxane-2,3,4,5-tetrol
b-D-Galactosebeta-D-Galbeta-D-GalactosideGalactitol,1,5-anhydro-1-C-phenyl-beta-Galactosidase9031-11-2(2R,3R,4S,5R,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraolCHEMBL300520
데이터베이스 식별자
- CAS
7296-64-2、9031-11-2- PubChem CID
- 439353
- DTXSID
DTXSID001015884- ChEMBL
CHEMBL300520- ChEBI
CHEBI:27667- UNII
- RQ6K52J67A
- EC Number
- 232-864-1
- Nikkaji
- J292.886H
물성
구조 계산 물성보충 중
- XLogP
- -2.6
- 극성 표면적
- 110 Ų
- 수소 결합 공여자 수
- 5
- 수소 결합 수용자 수
- 6
- 회전 가능 결합 수
- 1
- 무거운 원자 수
- 12
- 형식 전하
- 0
- 복잡도
- 151
실험 및 물리화학적 성질
Chemical ClassesBiological Agents -> Enzymes
SpringerMaterials PropertiesCrystal structure
SolubilitySlightly soluble
Physical Description
Powder; [Sigma-Aldrich MSDS]
Solid
물리화학적 성질
- 녹는점
- 179 · 179-179.5 °C
- 끓는 점
- 410.8 · 410.8±45.0 °C(Predicted)
- 밀도
- 1.732 · 1.732±0.06 g/cm3(Predicted)
- 저장 조건
- Hygroscopic, Refrigerator, under inert atmosphere
- 용해도
- 물(약간 용해됨)
- 물리적 상태
- 고체
- 산도 계수 (pKa)
- 12.12 · 12.12±0.70(Predicted)
- 색상
- 흰색에서 황백색까지
- 안정성
- 흡습성
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
GHS 분류
GHS Classification
Danger
H334 (99.9%): May cause allergy or asthma symptoms or breathing difficulties if inhaled [Danger Sensitization, respiratory]
P233, P260, P271, P284, P304+P340, P342+P316, P403, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 1506 reports by companies from 4 notifications to the ECHA C&L Inventory.
유해성 정보
Regulatory Information
Chemical: Galactosidase, .beta.-
Galactosidase, .beta.-: Does not have an individual approval but may be used under an appropriate group standard
.beta.-D-Galactopyranose: Does not have an individual approval but may be used under an appropriate group standard
Other Safety InformationIMAP assessments - Galactosidase, .beta.-: Environment tier I assessment
Hazards SummaryMay cause irritation; May cause allergic reactions in sensitive individuals; [Sigma-Aldrich MSDS] See ENZYMES.
Hazard Classes and CategoriesResp. Sens. 1 (99.9%)
화학 및 산업
약리 정보
ATC Code
A - Alimentary tract and metabolism
QA - Alimentary tract and metabolism
Protein BindingTilactase is not absorbed and thus the plasma protein binding is not possible.
Pharmacodynamics
The use of a single oral administration of tilactase has been shown to be highly effective in decreasing the symptoms and hydrogen excretion of hypolactasia in tests of lactose H(2)-breath. The analysis has shown a decrease of approximately 80% in both malabsorbers and intolerants.The administration of tilacatase also decreases the presence of bloating and flatus.
Mechanism of Action
Lactose is the primary disaccharide found in dairy products. Tilactase is a type of lactase which is the enzyme that is in charge of the breakdown of lactose to glucose and galactose which can be used by the body. Basically, tilactase acts by replacing the missing lactase in the body and allows avoidance of the reach of lactose to the small intestine and the normal bacteria and thus, preventing the symptoms of the lactose intolerance. Once tilactase has metabolized the lactose, the metabolism products are reabsorbed by the normal process of digestion.
Biological Half-LifeTilactase half-life at 35ºC is registered to be 123.77 min. This half-life can be affected by temperature in an inversely proportional manner.
Metabolism/MetabolitesTilactase is degraded by the stomach acid and by the normal flora bacterial metabolism.
Absorption, Distribution and Excretion
Tilactase is not absorbed in the GI tract and thus the pharmacokinetic parameters related to absorption are not relevant.
Tilactase is completely eliminated in the feces either unchanged or as metabolites.
Tilactase is not absorbed and thus the volume of distribution is not relevant.
Tilactase is not absorbed and thus the clearance rate is not relevant.
관련 반응
6건
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