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기본 정보
- CAS
83919-23-7- 표준 SMILES
C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(Cl)[C@@H](O)C[C@]2(C)[C@@]1(OC(=O)c1ccco1)C(=O)CCl- InChIKey
WOFMFGQZHJDGCX-ZULDAHANSA-N- 분자식
- C27H30Cl2O6
- 평균 분자량
- 521.437 g/mol
- 단동위원소 질량
- 520.14194404
이름 및 식별자
- 우선 이름
- Mometasone furoate
- IUPAC
- 9,21-Dichloro-11beta-hydroxy-16alpha-methyl-3,20-dioxopregna-1,4-dien-17-yl furan-2-carboxylate
- 영어명
- Mometasone furoate
- 분자식
- C27H30Cl2O6
- 분자량
- 521.43
이름 및 동의어
NASONEXMometason FuroateMOMETASONE 17-FUROATEMometasone Furoate Anhydrous(11β,16α)-9,21-Dichloro-17-[(2-furanylcarbonyl)oxy]-11-hydroxy-16-Methyl-pregna-1,4-diene-3,20-dione9-chloro-17-(2-chloroacetyl)-11,17-dihydroxy-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one furoateEcuralElocoMEloMetMonovo
데이터베이스 식별자
- CAS
83919-23-7- PubChem CID
- 441336
- DTXSID
DTXSID4023333- ChEMBL
CHEMBL1161- ChEBI
CHEBI:47564- UNII
- 04201GDN4R
- EC Number
- 617-501-0
- Nikkaji
- J258.527H
물성
물리화학적 성질
- 녹는점
- 218 · 218-220°C
- 끓는 점
- 655.5 · 655.5±55.0 °C(Predicted)
- 밀도
- 1.37 · 1.37±0.1 g/cm3(Predicted)
- 저장 조건
- 2 · 2-8°C
- 용해도
- 20 mg/mL · DMSO: ≥20mg/mL
- 물리적 상태
- 가루
- 산도 계수 (pKa)
- 13.02 · 13.02±0.70(Predicted)
- 색상
- 흰색에서 황백색까지
- InChIKey
- WOFMFGQZHJDGCX-ZULDAHANSA-N
- SMILES
- C[C@]12C[C@H](OC(=O)C3=CC=CO3)C3([C@](CCC4[C@]3(C)C=CC(=O)C=4)([H])[C@]1([H])C[C@@H](C)[C@]2(OC(=O)C1OC=CC=1)C(=O)CCl)Cl |&1:1,3,13,17,25,28,30,r|
화학적 성질
White-to-Off-White Solid
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
안전 데이터
- wgk
- 3
- HS 번호
- 29372290
- Hazard Classifications
- Repr. 1B
- 스토리지 클래스
- 6.1C - Combustible acute toxic Cat.3toxic compounds or compounds which causing chronic effects
화학 및 산업
응용 분야
개요Mometasone furoate is a topical steroidal antiinflammatory useful in the treatment of corticosteroid-responsive dermatoses. As a steroidal antiinflammatory of grade II potency, mometasone furoate is characterized by a once-daily dose regimen and a relatively wide safety margin.
용도Mometasone furoate is a deuterated topical corticosteroid used as an anti-inflammatory. Mometasone furoate has been used to study its effect on Leishmania major amastigotes. It could as labeled Mometasone, intended for use as an internal standard for the quantification of Mometasone by GC- or LC-mass spectrometry. Formulations containing mometasone furoate have been used in the treatment of allergic rhinitis, atopic dermatitis, and asthma. Intranasal administration of mometasone furoate (1 μg/nostril) reduces the frequency of sneezing and nasal rubbing in a rat model of histamine-induced allergic rhinitis. Topical application of mometasone furoate reduces croton oil-induced ear edema in mice (ED50 = 0.31 μg/ml).
일반 설명Mometasone furoate (Asmanex,Nasonex) undergoes extensive metabolism to multiplemetabolites. No major metabolites are detectable in humanplasma after oral administration, but the 6β-hydroxy metaboliteis detectable by use of human liver microsomes. Thismetabolite is formed via the CYP3A4 pathway.
상·하류 제품 정보
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