황산카나마이신
카나마이신,모노황산염 · 황산카나마이신 · 카나마이신,모노황산염(KANAMYCIN,MONOSULFATE) · KANAMYCIN MONOSULFATE · KANAMYCIN ACID SULFATE · KANAMYCIN SULPHATE · Kantrex · klebcil
식별자 및 물리적 특성
| CAS No. | 25389-94-0 |
|---|---|
| 분자식 | C18H38N4O15S |
| 평균 분자량 | 582.6 g/mol |
| 단동위원소 질량 | 582.20543769 g/mol |
| SMILES | NC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H](N)C[C@@H]2N)[C@H](O)[C@@H](O)[C@@H]1O.O=S(=O)(O)O |
| InChIKey | OOYGSFOGFJDDHP-KMCOLRRFSA-N |
| PubChem CID | 441374 |
| ChEMBL | CHEMBL1446 |
| ChEBI | CHEBI:6109 |
| EC No. | 223-347-1 |
| DTXSID | DTXSID1047524 |
| 현지명 | 황산카나마이신 |
화학 및 물리적 성질
| 극성 표면적 | 366 |
|---|---|
| 수소 결합 공여자 수 | 13 |
| 수소 결합 수용자 수 | 19 |
| 회전 가능 결합 수 | 6 |
| 무거운 원자 수 | 38 |
| 형식 전하 | 0 |
| 복잡도 | 720 |
| Collision Cross Section | 221.1 Ų [M+H]+ [CCS Type: TWMethod: calibrated with polyalanine and drug standards] |
| 녹는점 | 250°C |
| 밀도 | 1.3619 (rough estimate) |
| 굴절률 | 117.5 ° (C=1, H2O) |
| 저장 조건 | 2-8°C |
| 용해도 | H2O: 10-50 mg/mL 원액. 스톡 솔루션은 2-8°C에 보관해야 합니다. 37°C에서 5일 동안 안정합니다. |
| 물리적 상태 | 가루 |
| 색상 | 흰색에서 황백색까지 |
| 생물학적 소스 | Streptomyces kanamyceticus |
| 용해도 | 10mg/ml의 물에 용해됨 |
| Merck | 14,5281 |
| 주요 응용 | 의약품(소분자) |
| InChIKey | OOYGSFOGFJDDHP-KMCOLRRFSA-N |
| SMILES | OS(O)(=O)=O.NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O |
화학적 성질
Off-white powder
안전 및 규제
| GHS 분류 | This chemical does not meet GHS hazard criteria for 1% (1 of 96) of reports.DangerH360 (69.8%): May damage fertility or the unborn child [Danger Reproductive toxicity]H372 (29.2%): Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]H400 (29.2%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]H410 (29.2%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]P203, P260, P264, P270, P273, P280, P318, P319, P391, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 96 reports by companies from 10 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.Reported as not meeting GHS hazard criteria per 1 of 96 reports by companies.There are 9 notifications provided by 95 of 96 reports by companies with hazard statement code(s).Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. |
|---|---|
| Hazard Classes and Categories | Repr. 1B (69.8%)STOT RE 1 (29.2%)Aquatic Acute 1 (29.2%)Aquatic Chronic 1 (29.2%)Repr. 1B (100%) |
| 수질 위해 등급(WGK) | 3 |
| RTECS 번호 | NZ3225030 |
| 독성 | LD50 in mice: 20.7 g/kg orally1450 mg/kg i.p. (Zel'tser) |
| 관세 코드 | 29419020 |
| 위험 문구(R) | 61 |
| 위험 표시 | T |
| 안전 문구(S) | 22-24/25-45-53 |
| 기존화학 물질 | KE-21771 |
| 위험 등급 | Repr. 1B |
| 저장 분류 | 6.1D - Non-combustible acute toxic Cat.3toxic hazardous materials or hazardous materials causing chronic effects |
용도
개요
Kanamycin was found by Umezawa et al. in the culture broth of Streptomyces kanamyceticus in 1957. It is produced with other components, kanamycins B (bekanamycin) and C, which are also separated during the purification. The compound shows much lower toxicity than the earlier aminoglycosides, streptomycin and neomycin, and strong activity against a wide range of gram-positive and gram-negative bacteria, including Mycobacterium. Kanamycin has been used clinically for treatment of such serious infections as dysentery, salmonellosis, and tuberculosis.
용도
Kanamycin sulfate is an antibacterial agent similar to neomycin.
일반 설명
Kanamycin sulfate is a broad spectrum aminoglycoside-antibiotic derived from Streptomyces kanamyceticus. It is used as an additive in culture media for the isolation of group D streptococci on Kanamycin Esculin Azide Agar and for selection of transformed plant cells containing the neomycin phosphotransferase on a kanamycin-medium. Kanamycin sulfate can also be used as a selection agent for cells transformed with kanamycin B resistance gene. It is recommended for use in cell culture applications at 2 mL/L.