황산카나마이신
Kanamycin A Sulfate
기본 정보
- CAS
25389-94-0- 표준 SMILES
NC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H](N)C[C@@H]2N)[C@H](O)[C@@H](O)[C@@H]1O.O=S(=O)(O)O- InChIKey
OOYGSFOGFJDDHP-KMCOLRRFSA-N- 분자식
- C18H38N4O15S
- 평균 분자량
- 582.6 g/mol
- 단동위원소 질량
- 582.20543769
개요
Kanamycin A sulfate is an aminoglycoside sulfate salt. It has a role as a geroprotector and an antibacterial drug. It contains a kanamycin A.
이름 및 식별자
- 우선 이름
- Kanamycin A Sulfate
- IUPAC
- (2R,3S,4S,5R,6R)-2-(aminomethyl)-6-[(1R,2R,3S,4R,6S)-4,6-diamino-3-[(2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxyoxane-3,4,5-triol;sulfuric acid
- 현지명
- 황산카나마이신
- 영어명
- Kanamycin sulfate
- 분자식
- C18H38N4O15S
- 분자량
- 582.58
이름 및 동의어
Kanamycin A sulfateKanamycin A sulphateKanaplexDTXSID1047524J80EX28SMQEINECS 223-347-1(2R,3S,4S,5R,6R)-2-(aminomethyl)-6-[(1R,2R,3S,4R,6S)-4,6-diamino-3-[(2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxyoxane-3,4,5-triol;sulfuric acidCHEBI:6109DTXCID9027524KANAMYCIN A SULFATE [MI]KANAMYCIN SULFATE (USP-RS)KANAMYCIN SULFATE [USP-RS]
이름 더 보기
카나마이신,모노황산염황산카나마이신카나마이신,모노황산염(KANAMYCIN,MONOSULFATE)KANAMYCIN MONOSULFATEKANAMYCIN ACID SULFATEKANAMYCIN SULPHATEKantrexklebcilKanamycin AcidKanamycin monosulfate CRSkanoKAMYCINKantrim
KANAMYCIN SULFATE (USP MONOGRAPH)KANAMYCIN SULFATE [USP MONOGRAPH]KANAMYCIN MONOSULFATE (EP MONOGRAPH)KANAMYCIN MONOSULFATE [EP MONOGRAPH]D-STREPTAMINE, O-3-AMINO-3-DEOXY-.ALPHA.-D-GLUCOPYRANOSYL(1->6)-O-(6-AMINO-6-DEOXY-.ALPHA.-D-GLUCOPYRANOSYL(1->4))-2-DEOXY-, SULFATE (1:1) (SALT)D-STREPTAMINE, O-3-AMINO-3-DEOXY-.ALPHA.-D-GLUCOPYRANOSYL(1->6)-O-(6-AMINO-6-DEOXY-.ALPHA.-D-GLUCOPYRANOSYL(1->4))-2-DEOXY-, SULPHATE (1:1) (SALT)D-Streptamine, O-3-amino-3-deoxy-alpha-D-glucopyranosyl(1->6)-O-(6-amino-6-deoxy-alpha-D-glucopyranosyl(1->4))-2-deoxy-, sulfate (1:1) (salt)(2R,3S,4S,5R,6R)-2-(aminomethyl)-6-((1R,2R,3S,4R,6S)-4,6-diamino-3-((2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl)oxy-2-hydroxycyclohexyl)oxyoxane-3,4,5-triol;sulfuric acid
물성
구조 계산 물성
- 극성 표면적
- 366 Ų
- 수소 결합 공여자 수
- 13
- 수소 결합 수용자 수
- 19
- 회전 가능 결합 수
- 6
- 무거운 원자 수
- 38
- 형식 전하
- 0
- 복잡도
- 720
실험 및 물리화학적 성질
Human Drugs
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
Animal DrugsFDA approved animal drugs -> Active ingredient
Collision Cross Section221.1 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
물리화학적 성질
- 녹는점
- 250 °C · 250°C
- 밀도
- 1.3619 · 1.3619 (rough estimate)
- 굴절률
- 117.5 ° · 117.5 ° (C=1, H2O)
- 저장 조건
- 2 · 2-8°C
- 용해도
- 2 O: · H2O: 10-50 mg/mL 원액. 스톡 솔루션은 2-8°C에 보관해야 합니다. 37°C에서 5일 동안 안정합니다.
- 물리적 상태
- 가루
- 색상
- 흰색에서 황백색까지
- 생물학적 소스
- Streptomyces kanamyceticus
- 수용성
- 10 mg/ml의 · 10mg/ml의 물에 용해됨
- Merck
- 14 · 14,5281
- 주요 응용
- 의약품(소분자)
- InChIKey
- OOYGSFOGFJDDHP-KMCOLRRFSA-N
- SMILES
- OS(O)(=O)=O.NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
GHS 분류
GHS Classification
This chemical does not meet GHS hazard criteria for 1% (1 of 96) of reports.
Danger
H360 (69.8%): May damage fertility or the unborn child [Danger Reproductive toxicity]
P203, P260, P264, P270, P273, P280, P318, P319, P391, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 96 reports by companies from 10 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Danger
유해성 정보
Hazard Classes and Categories
Repr. 1B (69.8%)
Repr. 1B (100%)
안전 데이터
- wgk
- 3
- rtecs
- NZ3225030
- 독성
- LD50 in mice: 20.7 g/kg orally; 1450 mg/kg i.p. (Zel'tser)
- HS 번호
- 29419020
- risk_code
- 61
- hazard_code
- T
- safety_code
- 22-24/25-45-53
- 기존화학 물질
- KE-21771
- Hazard Classifications
- Repr. 1B
- 스토리지 클래스
- 6.1D - Non-combustible acute toxic Cat.3toxic hazardous materials or hazardous materials causing chronic effects
화학 및 산업
응용 분야
개요Kanamycin was found by Umezawa et al. in the culture broth of Streptomyces kanamyceticus in 1957. It is produced with other components, kanamycins B (bekanamycin) and C, which are also separated during the purification. The compound shows much lower toxicity than the earlier aminoglycosides, streptomycin and neomycin, and strong activity against a wide range of gram-positive and gram-negative bacteria, including Mycobacterium. Kanamycin has been used clinically for treatment of such serious infections as dysentery, salmonellosis, and tuberculosis.
용도Kanamycin sulfate is an antibacterial agent similar to neomycin.
일반 설명Kanamycin sulfate is a broad spectrum aminoglycoside-antibiotic derived from Streptomyces kanamyceticus. It is used as an additive in culture media for the isolation of group D streptococci on Kanamycin Esculin Azide Agar and for selection of transformed plant cells containing the neomycin phosphotransferase on a kanamycin-medium. Kanamycin sulfate can also be used as a selection agent for cells transformed with kanamycin B resistance gene. It is recommended for use in cell culture applications at 2 mL/L.
상·하류 제품 정보
상류 원료
추가 설명
정의A broadspectrum antibiotic.
관련 반응
11건
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