황산카나마이신

Kanamycin A Sulfate

HCID 441374CAS 25389-94-0
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기본 정보

표준 SMILES
NC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H](N)C[C@@H]2N)[C@H](O)[C@@H](O)[C@@H]1O.O=S(=O)(O)O
InChIKey
OOYGSFOGFJDDHP-KMCOLRRFSA-N
분자식
C18H38N4O15S
평균 분자량
582.6 g/mol
단동위원소 질량
582.20543769

이름 및 식별자

우선 이름
Kanamycin A Sulfate
IUPAC
(2R,3S,4S,5R,6R)-2-(aminomethyl)-6-[(1R,2R,3S,4R,6S)-4,6-diamino-3-[(2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxyoxane-3,4,5-triol;sulfuric acid
현지명
황산카나마이신
영어명
Kanamycin sulfate
분자식
C18H38N4O15S
분자량
582.58

이름 및 동의어

Kanamycin A sulfateKanamycin A sulphateDTXSID1047524J80EX28SMQEINECS 223-347-1(2R,3S,4S,5R,6R)-2-(aminomethyl)-6-[(1R,2R,3S,4R,6S)-4,6-diamino-3-[(2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxyoxane-3,4,5-triol;sulfuric acidCHEBI:6109DTXCID9027524KANAMYCIN A SULFATE [MI]KANAMYCIN SULFATE [USP-RS]KANAMYCIN SULFATE [USP MONOGRAPH]KANAMYCIN MONOSULFATE [EP MONOGRAPH]
이름 더 보기
카나마이신,모노황산염황산카나마이신카나마이신,모노황산염(KANAMYCIN,MONOSULFATE)KANAMYCIN MONOSULFATEKANAMYCIN ACID SULFATEKANAMYCIN SULPHATEKantrexklebcilKanamycin AcidKanamycin monosulfate CRSkanoKAMYCINKantrim
KANAMYCIN SULFATE (USP-RS)KANAMYCIN SULFATE (USP MONOGRAPH)D-STREPTAMINE, O-3-AMINO-3-DEOXY-.ALPHA.-D-GLUCOPYRANOSYL(1->6)-O-(6-AMINO-6-DEOXY-.ALPHA.-D-GLUCOPYRANOSYL(1->4))-2-DEOXY-, SULFATE (1:1) (SALT)D-STREPTAMINE, O-3-AMINO-3-DEOXY-.ALPHA.-D-GLUCOPYRANOSYL(1->6)-O-(6-AMINO-6-DEOXY-.ALPHA.-D-GLUCOPYRANOSYL(1->4))-2-DEOXY-, SULPHATE (1:1) (SALT)D-Streptamine, O-3-amino-3-deoxy-alpha-D-glucopyranosyl(1->6)-O-(6-amino-6-deoxy-alpha-D-glucopyranosyl(1->4))-2-deoxy-, sulfate (1:1) (salt)KANAMYCIN MONOSULFATE (EP MONOGRAPH)Kanaplex(2R,3S,4S,5R,6R)-2-(aminomethyl)-6-((1R,2R,3S,4R,6S)-4,6-diamino-3-((2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl)oxy-2-hydroxycyclohexyl)oxyoxane-3,4,5-triol;sulfuric acid

데이터베이스 식별자

CAS
25389-94-0、3847-27-6、64013-70-3
PubChem CID
441374
DTXSID
DTXSID1047524
ChEMBL
CHEMBL1446
ChEBI
CHEBI:6109
UNII
J80EX28SMQ
EC Number
223-347-1、613-414-7

물성

구조 계산 물성

극성 표면적
366 Ų
수소 결합 공여자 수
13
수소 결합 수용자 수
19
회전 가능 결합 수
6
무거운 원자 수
38

실험 및 물리화학적 성질

Collision Cross Section221.1 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

물리화학적 성질

녹는점
250 °C · 250°C
밀도
1.3619 · 1.3619 (rough estimate)
굴절률
117.5 ° · 117.5 ° (C=1, H2O)
저장 조건
2 · 2-8°C
용해도
2 O: · H2O: 10-50 mg/mL 원액. 스톡 솔루션은 2-8°C에 보관해야 합니다. 37°C에서 5일 동안 안정합니다.
물리적 상태
가루

화학적 성질

Off-white powder

안전 및 규제

GHS 분류

GHS Classification · 6건

This chemical does not meet GHS hazard criteria for 1% (1 of 96) of reports.

Danger

H360 (69.8%): May damage fertility or the unborn child [Danger Reproductive toxicity]；H372 (29.2%): Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]；H400 (29.2%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]；H410 (29.2%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]

P203, P260, P264, P270, P273, P280, P318, P319, P391, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 96 reports by companies from 10 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.；Reported as not meeting GHS hazard criteria per 1 of 96 reports by companies.；There are 9 notifications provided by 95 of 96 reports by companies with hazard statement code(s).；Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

유해성 정보

Hazard Classes and Categories · 2건

Repr. 1B (69.8%)；STOT RE 1 (29.2%)；Aquatic Acute 1 (29.2%)；Aquatic Chronic 1 (29.2%)

Repr. 1B (100%)

안전 데이터

wgk
3
rtecs
NZ3225030
독성
LD50 in mice: 20.7 g/kg orally; 1450 mg/kg i.p. (Zel'tser)
HS 번호
29419020
risk_code
61
hazard_code
T

화학 및 산업

용도 및 제조

Use ClassificationAnimal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients
응용 분야 · 3건

개요Kanamycin was found by Umezawa et al. in the culture broth of Streptomyces kanamyceticus in 1957. It is produced with other components, kanamycins B (bekanamycin) and C, which are also separated during the purification. The compound shows much lower toxicity than the earlier aminoglycosides, streptomycin and neomycin, and strong activity against a wide range of gram-positive and gram-negative bacteria, including Mycobacterium. Kanamycin has been used clinically for treatment of such serious infections as dysentery, salmonellosis, and tuberculosis.

용도Kanamycin sulfate is an antibacterial agent similar to neomycin.

일반 설명Kanamycin sulfate is a broad spectrum aminoglycoside-antibiotic derived from Streptomyces kanamyceticus. It is used as an additive in culture media for the isolation of group D streptococci on Kanamycin Esculin Azide Agar and for selection of transformed plant cells containing the neomycin phosphotransferase on a kanamycin-medium. Kanamycin sulfate can also be used as a selection agent for cells transformed with kanamycin B resistance gene. It is recommended for use in cell culture applications at 2 mL/L.

상·하류 제품 정보

공급사50 곳

国药集团化学试剂有限公司86-21-63210123 · [email protected]
北京华美互利生物化工010-56205725 · [email protected]
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
INTATRADE GmbH+49 3493/605464 · [email protected]

추가 설명

정의A broadspectrum antibiotic.

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