Paromomycin Sulfate

HCID 441375
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기본 정보

CAS
1263-89-4
표준 SMILES
NC[C@@H]1O[C@H](O[C@H]2[C@@H](O)[C@H](O[C@@H]3[C@@H](O)[C@H](N)C[C@H](N)[C@H]3O[C@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3N)O[C@@H]2CO)[C@H](N)[C@@H](O)[C@@H]1O.O=S(=O)(O)O
InChIKey
LJRDOKAZOAKLDU-UDXJMMFXSA-N
분자식
C23H47N5O18S
평균 분자량
713.7 g/mol
단동위원소 질량
713.26368084

이름 및 식별자

우선 이름
Paromomycin Sulfate
IUPAC
(2S,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-[(2R,3S,4R,5S)-5-[(1R,2R,3S,5R,6S)-3,5-diamino-2-[(2S,3R,4R,5S,6R)-3-amino-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-hydroxycyclohexyl]oxy-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]oxyoxane-3,4-diol;sulfuric acid
영어명
PAROMOMYCIN SULFATE
분자식
C23H47N5O18S
분자량
713.71

이름 및 동의어

Paromomycin sulfate1263-89-4GabbromicinaGabbroralHumagelAminosidin sulfateAminosidine sulfateAminosidine sulphateFarminosidinAminoxidinFarmiglucinSinosid
이름 더 보기
sulfhumatinNEOMYCIN EPAROMOMYCIN SULFATE SALTNeomycin Sulfate EP Impurity EO - 2, 6 - Diamino - 2, 6 - dideoxy - b - L - idopyranosyl - (1,3) - O - b - D - ribofuranosyl - (1,5) - O - [2 - amino - 2 - deoxy - a - D - glucopyranosyl - (1,4) ] - 2 - deoxy - streptamine sulfatefi5853D00868
PargonylHumycin sulfateParomomycin sulphateParamicinaParicina845NU6GJPSGabbromycin1600 Antibiotic

데이터베이스 식별자

CAS
1263-89-4、7205-49-4
PubChem CID
441375
DTXSID
DTXSID601335979
ChEMBL
CHEMBL2206196
ChEBI
CHEBI:7935
UNII
845NU6GJPS
EC Number
215-031-7、230-575-5

물성

구조 계산 물성

극성 표면적
430 Ų
수소 결합 공여자 수
15
수소 결합 수용자 수
23
회전 가능 결합 수
9
무거운 원자 수
47

물리화학적 성질

녹는점
145 °C · 145 °C (decomp)
저장 조건
Keep in dark place,Inert atmosphere,Room temperature
용해도
2 O: · H2O: 50 mg/mL。 원액을 2~8°C에 보관하세요. 37°C에서 5일 동안 안정합니다.
물리적 상태
가루
색상
흰색에서 황백색까지
수용성
물에 용해됨

화학적 성질

PAROMOMYCIN SULFATE is White to Off-White Solid

안전 및 규제

GHS 분류

GHS Classification · 3건

This chemical does not meet GHS hazard criteria for 93% (53 of 57) of all reports.

Not Classified；Reported as not meeting GHS hazard criteria by 53 of 57 companies (only 7% companies provided GHS information). For more detailed information, please visit ECHA C&L website.

Aggregated GHS information provided per 57 reports by companies from 5 notifications to the ECHA C&L Inventory.；Reported as not meeting GHS hazard criteria per 53 of 57 reports by companies.；There are 4 notifications provided by 4 of 57 reports by companies with hazard statement code(s).；Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

유해성 정보

Regulatory InformationRegulation (EC) No 1831/2003 (amended)
Hazard Classes and CategoriesNot Classified

독성 정보

Drug Induced Liver Injury · 6건

Drug Induced Liver Injury Rank (DILIrank 2.0)

Paromomycin sulfate

vNo-DILI-concern

0

No match

DOI:10.1016/j.drudis.2016.02.015

Effects During Pregnancy and Lactation · 1건

◉ Summary of Use during Lactation；No information is available on the clinical use of paromomycin during breastfeeding. Because paromomycin is poorly absorbed orally, it is not likely to reach the bloodstream of the infant or cause any adverse effects in breastfed infants.；◉ Effects in Breastfed Infants；Relevant published information was not found as of the revision date.；◉ Effects on Lactation and Breastmilk；Relevant published information was not found as of the revision date.

규제 정보

Regulatory InformationRegulation (EC) No 1831/2003 (amended)

안전 데이터

wgk
2
rtecs
WK2320000
독성
LD50 in mice (mg/kg): ~15,000 orally; 700 s.c.; 110 i.v. (Di Marco, Bertazzoli)
HS 번호
2941901010
risk_code
23/24/25-36/38-39/23/24/25-61-36/37/38
hazard_code
Xi

화학 및 산업

약리 정보

FDA Pharmacological Classification · 2건

PAROMOMYCIN SULFATE

Antiprotozoal [EPC]

MeSH Pharmacological Classification · 2건

Substances that are destructive to protozoans.

Substances that inhibit the growth or reproduction of BACTERIA.

응용 분야 · 3건

개요Paromomycin was found in the culture broth of Streptomyces rimosus forma paromomycinus by Parke Davis & Co. in 1959. In the same year it was found in the culture broth of S. Crestomyceticus by Farmitalia and named amminosidin. Paromomycin is related structurally to neomycin, but it has a hydroxyl group at the 6 position, whereas neomycin has an amino group. Its antibacterial activity is weaker than that of neomycin, but its toxicity is much less. Paromomycin is used by intramuscular injection for therapy of respiratory, urinary, and surgical infections and by oral administration to treat dysentery and salmonellosis.

용도PAROMOMYCIN SULFATE is an aminogycoside antibiotic designed to fight intestinal infections such as cryptosporidiosis, amoebiasis, and leishmaniasis. Its antiprotozoal activity makes it an effecive histomonostatic feed addit ive in turkey poults experimentally infected with Histomonas meleagridis.

일반 설명Chemical structure: aminoglycoside

공급사105 곳

国药集团化学试剂有限公司86-21-63210123 · [email protected]
北京华美互利生物化工010-56205725 · [email protected]
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
湖北威德利化学试剂有限公司181-6332-1995 18062128043 · [email protected]
추가 설명 · 1건

정의ChEBI: An aminoglycoside sulfate salt resulting from the treatment of paromomycin with sulfuric acid. A broad-spectrum antibiotic, it is used for the treatment of acute and chronic intestinal protozoal infections, but is not effective for extraintestinal protozoa infections. It is also used as a therapeutic against visceral leishmaniasis.

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