기본 정보
- CAS
125-02-0- 표준 SMILES
C[C@]12C=CC(=O)C=C1CC[C@@H]1[C@@H]2[C@@H](O)C[C@@]2(C)[C@H]1CC[C@]2(O)C(=O)COP(=O)([O-])[O-].[Na+].[Na+]- InChIKey
VJZLQIPZNBPASX-OJJGEMKLSA-L- 분자식
- C21H27Na2O8P
- 평균 분자량
- 484.4 g/mol
- 단동위원소 질량
- 484.12389301
개요
Prednisolone sodium phosphate can cause developmental toxicity according to state or federal government labeling requirements.
이름 및 식별자
- 우선 이름
- Prednisolone Sodium Phosphate
- IUPAC
- disodium;[2-[(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] phosphate
- 현지명
- 프레드니솔론소듐포스페이트
- 영어명
- Prednisolone phosphate sodium
- 분자식
- C21H27Na2O8P
- 분자량
- 484.39
이름 및 동의어
prednisolone sodium phosphate125-02-0HydeltrasolPediapredPrednisolone phosphate sodiumPhortisolonePrednisolone disodium phosphateMetretonOrapredPredairInflamase FortePredair Forte
이름 더 보기
프레드니솔론소듐포스페이트PREDNISONE SODIUM PHOSPHATESODIUM PREDNISOLONE-21-PHOSPHATEPrednisolone sodium phosphate CRSdisodium prednisolone 21-phosphatepredsol
CodelsolInflamaseMillipredPrednesolPredsolanProzorinSolucortOptival
데이터베이스 식별자
- CAS
125-02-0- PubChem CID
- 441409
- DTXSID
DTXSID2047480- ChEMBL
CHEMBL1201014- ChEBI
CHEBI:8379- UNII
- IV021NXA9J
물성
구조 계산 물성
- 극성 표면적
- 147 Ų
- 수소 결합 공여자 수
- 2
- 수소 결합 수용자 수
- 8
- 회전 가능 결합 수
- 3
- 무거운 원자 수
- 32
- 형식 전하
- 0
- 복잡도
- 878
실험 및 물리화학적 성질
Human Drugs
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
Animal DrugsActive Ingredients (Prednisolone Sodium Phosphate) -> FDA Greenbook
Collision Cross Section197.8 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
물리화학적 성질
- 녹는점
- 197 °C · >197°C (dec.)
- 저장 조건
- Inert atmosphere,Room Temperature
- 용해도
- 물에는 잘 녹고, 에탄올에는 아주 약간 녹습니다(96%).
- 물리적 상태
- Solid
- 색상
- 흰색에서 황백색까지
- Merck
- 14 · 14,7721
- 안정성
- 흡습성
- 주요 응용
- 소분자 약용
- InChIKey
- VJZLQIPZNBPASX-UHFFFAOYSA-L
- SMILES
- [Na+].[Na+].[P](=O)([O-])([O-])OCC(=O)C1(C2(C(C3C(C4(C(=CC(=O)C=C4)CC3)C)C(C2)O)CC1)C)O
- EPA
- -1 · Pregna-1,4-diene-3,20-dione, 11,17-dihydroxy-21-(phosphonooxy)-, disodium salt, (11.beta.)- (125-02-0)
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
GHS 분류
GHS Classification
This chemical does not meet GHS hazard criteria for 3.3% (3 of 90) of reports.
Warning
H302 (32.2%): Harmful if swallowed [Warning Acute toxicity, oral]
P203, P260, P261, P264, P270, P271, P280, P301+P317, P304+P340, P317, P318, P319, P330, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 90 reports by companies from 11 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
유해성 정보
Regulatory Information
Hazard Traits - Developmental Toxicity
Pregna-1,4-diene-3,20-dione, 11,17-dihydroxy-21-(phosphonooxy)-, disodium salt, (11.beta.)-: Does not have an individual approval but may be used under an appropriate group standard
Other Safety InformationIMAP assessments - Pregna-1,4-diene-3,20-dione, 11,17-dihydroxy-21-(phosphonooxy)-, disodium salt, (11.beta.)-: Environment tier I assessment
Hazard Classes and CategoriesAcute Tox. 4 (32.2%)
안전 데이터
- wgk
- 3
- tsca
- TSCA listed
- rtecs
- TU4153300
- HS 번호
- 2937290000
- Hazard Classifications
- Repr. 2STOT RE 2
- 스토리지 클래스
- 11 - Combustible Solids
화학 및 산업
약리 정보
FDA Pharmacological Classification
PREDNISOLONE SODIUM PHOSPHATE
Corticosteroid [EPC]; Corticosteroid Hormone Receptor Agonists [MoA]
MeSH Pharmacological Classification
A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system.
용도 및 제조
Use ClassificationAnimal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients
General Manufacturing InformationPregna-1,4-diene-3,20-dione, 11,17-dihydroxy-21-(phosphonooxy)-, disodium salt, (11.beta.)-: INACTIVE
응용 분야
개요Prednisolone is a synthetic analog of the natural glucocorticoid corticosterone that has anti-inflammatory and immunsuppressive actions. It avidly binds both glucocorticoid and mineralocorticoid receptors (Kis = 2.4 and 37 nM). Prednisolone Phosphate, prepared as the sodium salt, is a water-soluble ester of the poorly soluble parent molecule, prednisolone. It is rapidly hydrolyzed in vivo to the parent molecule when administered intravenously. In addition, when given orally, prednisolone phosphate is more readily absorbed than prednisolone, resulting in a higher effective blood concentration of prednisolone.
용도antiinflammatory
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