(+/-)-나르웨딘

(+)-Narwedine

HCID 441596

노트 반응

부분 구조 검색 유사 구조 찾기

기본 정보

CAS: 1668-86-6
표준 SMILES: COc1ccc2c3c1O[C@@H]1CC(=O)C=C[C@]31CCN(C)C2
InChIKey: QENVUHCAYXAROT-RHSMWYFYSA-N
분자식: C17H19NO3
평균 분자량: 285.34 g/mol

개요

(+)-narwedine has been reported in Amaryllidaceae, Leucojum aestivum, and other organisms with data available.

이름 및 식별자

우선 이름: (+)-Narwedine
IUPAC: (1R,12R)-9-methoxy-4-methyl-11-oxa-4-azatetracyclo[8.6.1.01,12.06,17]heptadeca-6(17),7,9,15-tetraen-14-one
현지명: (+/-)-나르웨딘
영어명: (+/-)-Narwedine
분자식: C17H19NO3
분자량: 285.34

이름 및 동의어

(+)-NarwedineNarwedine, (+)-7318-55-0UNII-6A3S1D0Z5T6A3S1D0Z5T1668-86-6(4aR,8aR)-3-methoxy-11-methyl-4a,5,9,10,11,12-hexahydro-6H-benzo[2,3]benzofuro[4,3-cd]azepin-6-one6H-Benzofuro[3a,3,2-ef][2]benzazepin-6-one, 4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-, (4aR,8aR)-rel-(+/-)-Narwedinerel-(4aR,8aR)-3-Methoxy-11-methyl-4a,5,9,10,11,12-hexahydro-6H-benzo[2,3]benzofuro[4,3-cd]azepin-6-one(+) narwedine(+)-GALANTHAMINONE

이름 더 보기

(+/-)-나르웨딘(4aR8aR)-rel-DL-Narwedine(+/-) NAWEDINEL(+)-Narwedine(+/-s)Narwedin6H-Benzofuro[3aNarwedine,racemic2-ef][2]benzazepin-6-one

SCHEMBL13993768AKOS015909405(1R,12R)-9-methoxy-4-methyl-11-oxa-4-azatetracyclo[8.6.1.01,12.06,17]heptadeca-6(17),7,9,15-tetraen-14-oneNS00077733H36277Q27264396GALANTHAMINE, 3-DEOXY-3-OXO-, (4A.BETA.,4BS*)-6H-BENZOFURO(3A,3,2-EF)(2)BENZAZEPIN-6-ONE, 4A,5,9,10,11,12-HEXAHYDRO-3-METHOXY-11-METHYL-, (4AR,8AR)-

데이터베이스 식별자

CAS: 1668-86-6、7318-55-0
PubChem CID: 441596
UNII: 6A3S1D0Z5T
EC Number: 605-454-9
Nikkaji: J977.690G

물성

구조 계산 물성

XLogP: 1.7
극성 표면적: 38.8 Å²
수소 결합 공여자 수: 0
수소 결합 수용자 수: 4
회전 가능 결합 수: 1
무거운 원자 수: 21
형식 전하: 0
복잡도: 477

물리화학적 성질

녹는점: 198 · 198-199 °C(Solv: ethyl acetate (141-78-6))
끓는 점: 397.4 · 397.4±42.0 °C(Predicted)
밀도: 1.28 · 1.28
산도 계수 (pKa): 7.84 · 7.84±0.20(Predicted)
InChI: InChI=1/C17H19NO3/c1-18-8-7-17-6-5-12(19)9-14(17)21-16-13(20-2)4-3-11(10-18)15(16)17/h3-6,14H,7-10H2,1-2H3/t14-,17-/s3
InChIKey: QENVUHCAYXAROT-OALMKZFLNA-N
SMILES: N1(C)CC2=CC=C(OC)C3O[C@@]4([H])[C@](C=CC(=O)C4)(C2=3)CC1 |&1:11,13,r|

안전 및 규제

GHS 분류

GHS Classification · 6건

Warning

H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]

P203, P264, P264+P265, P270, P273, P280, P301+P317, P305+P351+P338, P318, P330, P337+P317, P405, and P501 (click each P-code to see the statement)

The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

Warning

H302: Harmful if swallowed [Warning Acute toxicity, oral]

유해성 정보

Hazard Classes and Categories · 2건

Acute Tox. 4 (100%)

Acute toxicity - category 4

안전 데이터

신호 어: Warning
유해·위험 문구: 암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드 H302

화학 및 산업

응용 분야 · 1건

용도Narwedine is the biogenetic precursor of galanthamine, has been studied as a respiratory stimulator. It increases the amplitude and decreases the frequency of cardiac contractions and would therefore be of value in reducing blood loss during surgery. It also inhibits the action of narcotics and hypnotics, and increases the analgesic effect of morphine as well as the pharmacological effects of caffeine, carbazole, arecoline, and nicotine.

공급사42 곳

湖北永阔科技有限公司027-59223108 15972152991 · [email protected]

上海策嵘生物科技有限公司[email protected]

广州佳途科技股份有限公司81960175 18933936954 · [email protected]

Suzhou ARTK Medchem Co., Ltd.+86-18168183658 · [email protected]

爱斯特（成都）生物制药股份有限公司+86-28-85122536 85324413 · [email protected]

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