Metenkefalin

HCID 443363CAS 58569-55-4
부분 구조 검색유사 구조 찾기

기본 정보

표준 SMILES
CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)O
InChIKey
YFGBQHOOROIVKG-FKBYEOEOSA-N
분자식
C27H35N5O7S
평균 분자량
573.7 g/mol
단동위원소 질량
573.22571965

이름 및 식별자

우선 이름
Metenkefalin
IUPAC
(2S)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylsulfanylbutanoic acid
영어명
H-Tyr-Gly-Gly-Phe-Met-OH
분자식
C27H35N5O7S
분자량
573.66

이름 및 동의어

MET-enkephalin58569-55-4Methionine enkephalinTyr-Gly-Gly-Phe-Met-OHMETENKEFALINTYR-GLY-GLY-PHE-METLupex(Met5)-enkephalinOpioid growth factorENKEPHALIN, METHIONINE9JEZ9OD3ASPorcine beta-endorphin 1-5
이름 더 보기
YGGFMENKEPHALIN MMet-Enkephalie5Met-enkephalinENDORPHIN (1-5)Met-Enkephaline
Sh-pentapeptide-19Inno-105[Met5]-ENKEPHALINopioid growth factor (OGF)Enkephalin-(5-l-methionine)(2S)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylsulfanylbutanoic acidNSC-374896metencefalina

데이터베이스 식별자

CAS
58569-55-4
PubChem CID
443363
DTXSID
DTXSID90974125
ChEMBL
CHEMBL13786
UNII
9JEZ9OD3AS
EC Number
261-335-8
Nikkaji
J246.108K

물성

구조 계산 물성

XLogP
-2.1
극성 표면적
225 Ų
수소 결합 공여자 수
7
수소 결합 수용자 수
9
회전 가능 결합 수
16
무거운 원자 수
40

물리화학적 성질

녹는점
174 · 174-177 °C
끓는 점
1052.9 · 1052.9±65.0 °C(Predicted)
밀도
1.324 · 1.324±0.06 g/cm3(Predicted)
저장 조건
-20 °C · Keep in dark place,Sealed in dry,Store in freezer, under -20°C
용해도
DMSO(약간 용해됨), 메탄올(약간 용해됨, 가열, 초음파 처리), 물(약간 용해됨)
물리적 상태
가루

안전 및 규제

안전 데이터

wgk
3
safety_code
22-24/25
F 고인화성물질
3-10-21

화학 및 산업

약리 정보

Mechanism of Action · 1건

Metenkefalin is an agonist of µ and δ opioid receptors. It also causes immunostimulation at low doses and immunosuppression at higher doses. Metenkefalin can also inhibit the production of aldosterone, deoxycorticosterone, and corticosterone. Unfortunately, the mechanisms by which these effects occur have not been well described in the literature.

Biological Half-LifeThe half life of metenkefalin is 4.2-39 minutes.
MeSH Pharmacological Classification · 1건

Substances used for their pharmacological actions on any aspect of neurotransmitter systems. Neurotransmitter agents include agonists, antagonists, degradation inhibitors, uptake inhibitors, depleters, precursors, and modulators of receptor function.

Absorption, Distribution and ExcretionMetenkefalin reaches a Cmax of 1266.14pg/mL, with a Tmax of 0.16h, and an AUC of 360.64pg\*h/mL.

응용 분야

용도Endogenous opioid peptide that also functions as a growth factor on many cell types at a receptor that is distinct from the neuronal opioid receptors

상·하류 제품 정보

공급사50 곳

LIDE PHARMACEUTICALS LIMITED+852-55945652 · [email protected]
上海麦克林生化科技股份有限公司021-50706066 15221275939 · [email protected]
Hangzhou Go Top Peptide Biotech0571-88211921 · [email protected]
南京昱盛康生物科技有限公司13327808530 · [email protected]
Baoji Guokang Healthchem co.,ltd+8615604608665 15604608665 · [email protected]

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