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Cosmetic ingredients (Zinc Gluconate) -> CIR (Cosmetic Ingredient Review)

Skin conditioning; Deodorant

This chemical does not meet GHS hazard criteria for 14.7% (39 of 266) of reports.

Danger

H318 (81.6%): Causes serious eye damage [Danger Serious eye damage/eye irritation]

P264+P265, P273, P280, P305+P354+P338, P317, P391, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 266 reports by companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Chemical: Zinc, bis(D-gluconato-.kappa.O1,.kappa.O2)-, (T-4)-

Status: Active Update: 20-12-2018 https://echa.europa.eu/registration-dossier/-/registered-dossier/24253

Zinc, bis(D-gluconato-.kappa.O1,.kappa.O2)-, (T-4)-: Does not have an individual approval but may be used under an appropriate group standard

Generally regarded as safe (GRAS) for use as dietary supplement and nutrient; [HSDB] At oral doses of 47 mg/kg, volunteers complained of distorted perceptions and nausea or vomiting; Intravenous LD50 (mouse) = 23.7 mg/kg; Oral LD50 (mouse) = 1290 mg/kg; [ChemIDplus] May cause irritation; [MSDSonline] See Zinc.

Zinc and Health. Current Bibliographies in Medicine 98-3. Public Services Division/National Library of Medicine. 3619 citations January, 1990-June, 1998. Available from: http://www.nlm.nih.gov/archive/20040831/pubs/cbm/zinc.html as of November 2, 1998.

USEPA; Ambient Water Quality Criteria Doc: Zinc (1980) EPA 400/5-80-079

USEPA; Ambient Water Quality Criteria Doc: Zinc (1987) EPA 400/5-87-003

Arvidson, B. A Review of Axonal Transport of Metals. Toxicology 88: 1-14 (19994) Recent findings regarding axonal transport of metals, including zinc.

For more Special Reports (Complete) data for ZINC GLUCONATE (6 total), please visit the HSDB record page.

Toxic pollutant designated pursuant to section 307(a)(1) of the Clean Water Act and is subject to effluent limitations. /Zinc and compounds/

For total recoverable zinc the criterion-to protect freshwater aquatic life ... is 47 ng/l as a 24 hr average ... at hardnesses of 50, 100, and 200 mg/l as CaCO3 the concentration of total recoverable zinc should not exceed 180, 320, 570 ug/l at any time. /Soluble zinc salts/

For total recoverable zinc the criterion to protect saltwater aquatic life ... is 58 ug/l as a 24 hr average and the concentration should not exceed 170 ug/l at any time. /Soluble zinc salts/

(AZ) ARIZONA 5000 ug/l /Zinc/

(MN) MINNESOTA 2000 ug/l /Zinc/

EPA 5000 ug/l /Zinc/

EPA 2000 ug/l /Zinc, Lifetime health advisory/

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

Large doses of zinc may inhibit copper absorption in the intestine; zinc supplements should be taken at least 2 hours after the administration of copper supplements. /Zinc supplements/

Thiazide diuretics have been found to increase urinary zinc excretion. /Zinc supplements/

Concurrent use of large amounts of fiber, phosphorus, or phytates with zinc supplements may reduce zinc absorption by formation of nonabsorbable complexes; food containing fiber, phosphorus, or phytates should be taken at least 2 hours after zinc supplements. /Zinc supplements/

Some studies have found that folate can decrease the absorption of zinc, but not in the presence of excessive zinc; other studies have found no inhibition. /Zinc supplements/

For more Interactions (Complete) data for ZINC GLUCONATE (8 total), please visit the HSDB record page.

The CIR Expert Panel concluded that the following 27 zinc salts are safe in cosmetics in the present practices of use and concentration described in this safety assessment when formulated to be non-irritating...Zinc Gluconate...

Safe for use in cosmetics, with qualifications

Anaemia results from the excessive absorption of zinc suppressing copper and iron absorption, most likely through competitive binding of intestinal mucosal cells. Unbalanced levels of copper and zinc binding to Cu,Zn-superoxide dismutase has been linked to amyotrophic lateral sclerosis (ALS). Stomach acid dissolves metallic zinc to give corrosive zinc chloride, which can cause damage to the stomach lining. Metal fume fever is thought to be an immune response to inhaled zinc. (L48, L49, A49)

Ingestion of large doses of zinc causes stomach cramps, nausea, and vomiting. Acute inhalation of large amounts of zinc causes metal fume fever, which is characterized by chills, fever, headache, weakness, dryness of the nose and throat, chest pain, and coughing. Dermal contact with zinc results in skin irritation. (L49)

Toxic pollutant designated pursuant to section 307(a)(1) of the Clean Water Act and is subject to effluent limitations. /Zinc and compounds/

For total recoverable zinc the criterion-to protect freshwater aquatic life ... is 47 ng/l as a 24 hr average ... at hardnesses of 50, 100, and 200 mg/l as CaCO3 the concentration of total recoverable zinc should not exceed 180, 320, 570 ug/l at any time. /Soluble zinc salts/

For total recoverable zinc the criterion to protect saltwater aquatic life ... is 58 ug/l as a 24 hr average and the concentration should not exceed 170 ug/l at any time. /Soluble zinc salts/

(AZ) ARIZONA 5000 ug/l /Zinc/

(MN) MINNESOTA 2000 ug/l /Zinc/

EPA 5000 ug/l /Zinc/

EPA 2000 ug/l /Zinc, Lifetime health advisory/

A - Alimentary tract and metabolism

QA - Alimentary tract and metabolism

Recommended intakes may be increased and/or supplementation may be necessary in the following conditions (based on documented zinc deficiency): alcoholism; burns; cirrhosis of the liver; diabetes mellitus; eating disorders - anorexia nervosa, bulimia; gastrectomy; genetic disorders - celiac, Crohn's, diarrhea, sprue, ulcerative colitis; intestinal parasitism; malabsorption syndromes associated with pancreatic insufficiency - pancreatic disease, cystic fibrosis; renal diseases - nephrotic syndrome, renal failure, uremia; short bowel syndrome; skin disorders - exfoliative dermatoses, psoriasis; prolonged stress; prolonged trauma. /Zinc supplements/

Zinc is an important mineral found in almost every cell in the human body. It promotes the activity of about 100 enzymes. Zinc deficiency is often associated with an increased risk of infection. When they are used to treat the common cold, zinc supplements may interfere with rhinovirus cleavage or adhesion and may play a role in protecting plasma membranes from microbial toxins and complement.

Please refer to DrugBank entry [DB01593]

Zinc can enter the body through the lungs, skin, and gastrointestinal tract. Intestinal absorption of zinc is controlled by zinc carrier protein CRIP. Zinc also binds to metallothioneins, which help prevent absorption of excess zinc. Zinc is widely distributed and found in all tissues and tissues fluids, concentrating in the liver, gastrointestinal tract, kidney, skin, lung, brain, heart, and pancreas. In the bloodstream zinc is found bound to carbonic anhydrase in erythrocytes, as well as bound to albumin, _2-macroglobulin, and amino acids in the the plasma. Albumin and amino acid bound zinc can diffuse across tissue membranes. Zinc is excreted in the urine and faeces. (L49)

ZINC GLUCONATE

Copper Absorption Inhibitor [EPC]; Decreased Copper Ion Absorption [PE]

ZINCUM GLUCONICUM

Decreased Copper Ion Absorption [PE]; Copper Absorption Inhibitor [EPC]

Please refer to DrugBank entry [DB01593]

Feces and urine

Stored primarily in skeletal muscle and bone.

Please refer to DrugBank entry [DB01593]

CIR ingredient: Zinc Gluconate

Used as dietary supplement and food additive; Also used in human and veterinary medicine; [HSDB] Used as a chelating agent, high alkalinity bottle cleanser, finish remover, and in the tanning and textile industries; [Merck Index]

Textiles (Fiber & Fabric Manufacturing) [Category: Industry]

Dietary supplement and food additive

MEDICATION

MEDICATION (VET)

Descote zinc gluconate: Microencapsulated beaded powder containing 25% zinc gluconate & 75% edible coating

USP powder, granular & direct compressible grades

USP21 powder & fine granular grades

Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients

Cosmetics -> Skin conditioning; Deodorant