기본 정보
- CAS
36357-77-4- 표준 SMILES
CC(C)C[C@H](NP(=O)(O)O[C@@H]1O[C@@H](C)[C@H](O)[C@@H](O)[C@H]1O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O- InChIKey
ZPHBZEQOLSRPAK-XLCYBJAPSA-N- 분자식
- C23H34N3O10P
- 평균 분자량
- 543.5 g/mol
- 단동위원소 질량
- 543.19818129
개요
Phosphoramidon is a dipeptide isolated from the cultures of Streptomyces tanashiensis. It has a role as a bacterial metabolite, an EC 3.4.24.11 (neprilysin) inhibitor and an EC 3.4.24.71 (endothelin-converting enzyme 1) inhibitor. It is a deoxyaldohexose phosphate and a dipeptide.
이름 및 식별자
- 우선 이름
- Phosphoramidon
- IUPAC
- (2S)-2-[[(2S)-2-[[hydroxy-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyphosphoryl]amino]-4-methylpentanoyl]amino]-3-(1H-indol-3-yl)propanoic acid
- 현지명
- 포스포라미돈
- 영어명
- PHOSPHORAMIDON
- 분자식
- C23H34N3O10P
- 분자량
- 543.51
이름 및 동의어
phosphoramidon36357-77-4T3G94E2LB1DTXSID601317292CHEBI:45353N-(alpha-l-rhamnopyranosyloxyhydroxyphosphinyl)-l-leucyl-l-tryptophanL-Tryptophan, N-(N-(((6-deoxy-alpha-L-mannopyranosyl)oxy)hydroxyphosphinyl)-L-leucyl)-(2S)-2-[[(2S)-2-[[hydroxy-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyphosphoryl]amino]-4-methylpentanoyl]amino]-3-(1H-indol-3-yl)propanoic acid(2S)-2-(((2S)-2-((hydroxy-((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyl-tetrahydropyran-2-yl)oxy-phosphoryl)amino)-4-methyl-pentanoyl)amino)-3-(1H-indol-3-yl)propanoic acid(2S)-2-(((2S)-2-((hydroxy-((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl)oxyphosphoryl)amino)-4-methylpentanoyl)amino)-3-(1H-indol-3-yl)propanoic acid(2S)-2-[[(2S)-2-[[hydroxy-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyl-tetrahydropyran-2-yl]oxy-phosphoryl]amino]-4-methyl-pentanoyl]amino]-3-(1H-indol-3-yl)propanoic acidRefChem:862372
이름 더 보기
포스포라미돈eucyl)-yptophanPHOSPHORAMIDON SODIUM SALTPhosphoramidon (0.5 mg vial)PHOSPHORAMIDON DISODIUM SALT DIHYDRATEZ-Val-Ala-Asp(OMe)-CH2Fv [Z-VAD-FMK] (1mg vial)N-(A-RHAMNOPYRANOSYLOXYHYDROXYPHOSPHINYL)-LEU-TRPN-(ALPHA-RHAMNOPYRANOSYLOXYHYDROXYPHOSPHINYL)-LEU-TRP-OHN-(ALPHA-RHAMNOPYRANOSYLOXYHYDROXYPHOSPHINYL)-LEU-TRP 2NA
DTXCID001747112252-996-3PhosphramidonPhosporamidonN-ALPHA-L-RHAMNOPYRANOSYLOXY(HYDROXYPHOSPHINYL)-L-LEUCYL-L-TRYPTOPHANCHEMBL479579N-(N-(((6-Deoxy-alpha-L-mannopyranosyl)oxy)hydroxyphosphinyl)-L-leucyl)-L-tryptophan(2S)-2-((2S)-2-((Hydroxy(((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)phosphoryl)amino)-4-methylpentanamido)-3-(1H-indol-3-yl)propanoic acid
데이터베이스 식별자
- CAS
36357-77-4- PubChem CID
- 445114
- DTXSID
DTXSID601317292- ChEMBL
CHEMBL479579- ChEBI
CHEBI:45353- UNII
- T3G94E2LB1
- EC Number
- 252-996-3
- Nikkaji
- J18.388A
물성
구조 계산 물성
- XLogP
- -0.2
- 극성 표면적
- 211 Ų
- 수소 결합 공여자 수
- 8
- 수소 결합 수용자 수
- 11
- 회전 가능 결합 수
- 11
- 무거운 원자 수
- 37
- 형식 전하
- 0
- 복잡도
- 848
실험 및 물리화학적 성질
DrugsPharmaceuticals -> Listed in ZINC15
물리화학적 성질
- 밀도
- 1.48 · 1.48±0.1 g/cm3(Predicted)
- 저장 조건
- 20 °C · −20°C
- 용해도
- 2 O: · H2O: 1mM 스톡 용액은 –20°에서 1개월 동안 안정적입니다.
- 산도 계수 (pKa)
- -0.66 · -0.66±0.50(Predicted)
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
안전 데이터
- wgk
- 3
- safety_code
- 22-24/25
- F 고인화성물질
- 10-21
화학 및 산업
약리 정보
MeSH Pharmacological Classification
Compounds which inhibit or antagonize biosynthesis or actions of proteases (ENDOPEPTIDASES).
Substances that inhibit the growth or reproduction of BACTERIA.
공급사13 곳
阿诺西（上海）生物技术有限公司400-1107768 15058188853 · [email protected]
武汉易泰科技有限公司上海分公司18930552037 · [email protected]
张家港阿拉宁生化技术有限公司512-58900862 400-0707518 · [email protected]
四川库利南科技有限公司400-1166-196 18981987031 · [email protected]
上海谱科生物技术有限公司021-64705760 18027310741 · [email protected]
上海陶术生物科技股份有限公司+1-781-999-5354; +1-00000000000 · [email protected]
武汉福鑫化工有限公司+86-2759207851; +86-18007136271 · [email protected]
山东西亚化学有限公司4009903999 13395398332 · [email protected]
Alabiotech Inc.001-619-354-5251 · [email protected]
Adachibio Inc.+81-8027837258 · [email protected]
大连阿拉宁生物技术有限公司0411-39042497 · [email protected]
DAYANG CHEM (HANGZHOU) CO.,LTD+86-88938639 +86-17705817739 · [email protected]
TargetMol中国（陶术生物）15002134094 · [email protected]
추가 설명
정의ChEBI: A dipeptide isolated from the cultures of Streptomyces tanashiensis.
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