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기본 정보
- CAS
1199236-64-0- 표준 SMILES
CC(C)(C)NC(=O)CN1CCC(CNC(=O)c2cc(F)cc(Cl)c2)CC1- InChIKey
JOCLITFYIMJMNK-UHFFFAOYSA-N- 분자식
- C19H27ClFN3O2
- 평균 분자량
- 383.895 g/mol
- 단동위원소 질량
- 383.177583
이름 및 식별자
- 우선 이름
- N-({1-[2-(tert-Butylamino)-2-oxoethyl]piperidin-4-yl}methyl)-3-chloro-5-fluorobenzamide
- IUPAC
- N-({1-[2-(tert-Butylamino)-2-oxoethyl]piperidin-4-yl}methyl)-3-chloro-5-fluorobenzamide
- 영어명
- N-((1-(2-(tert-ButylaMino)-2-oxoethyl)piperidin-4-yl)Methyl)-3-chloro-5-fluorobenzaMide
- 분자식
- C19H27ClFN3O2
- 분자량
- 383.89
이름 및 동의어
UlixacaltamideZ-944Z944, 10 mM in DMSOUlixacaltamide (Z944)Ulixacaltamide (PRAX-944)N-[[1-[2-(tert-butylamino)-2-Ca channels,Inhibitor,Calcium Channel,Ca2+ channels,Z944,inhibitN-((1-(2-(tert-ButylaMino)-2-oxoethyl)piperidin-4-yl)Methyl)-3-chloro-5-fluorobenzaMide4-[[(3-Chloro-5-fluorobenzoyl)aMino]Methyl]-N-(1,1-diMethylethyl)-1-piperidineacetaMide1-Piperidineacetamide, 4-[[(3-chloro-5-fluorobenzoyl)amino]methyl]-N-(1,1-dimethylethyl)-
데이터베이스 식별자
- CAS
1199236-64-0- PubChem CID
- 44540045
- DTXSID
DTXSID60659275- ChEMBL
CHEMBL3934636- ChEBI
CHEBI:194339- UNII
- QT2PJH89C3
물성
물리화학적 성질
- 녹는점
- 122 · 122-124°C
- 끓는 점
- 528.1 · 528.1±50.0 °C(Predicted)
- 밀도
- 1.166 · 1.166±0.06 g/cm3(Predicted)
- 저장 조건
- Refrigerator
- 용해도
- 클로로포름(약간 용해됨), 메탄올(약간 용해됨)
- 산도 계수 (pKa)
- 13.65 · 13.65±0.46(Predicted)
- 물리적 상태
- 고체
- 색상
- 흰색에서 황백색까지
화학적 성질
White Solid
화학 및 산업
응용 분야
개요Z944 is an inhibitor of T-type calcium channels (IC50s = 0.050-0.160 μM for the human recombinant voltage-gated calcium (Cav) channels Cav3.1, Cav3.2, and Cav3.3). It is selective for T-type channels over the N-type Cav2.2 channel (IC50 = 11 μM), as well as the rat L-type Cav1.2, human-ether-a-go-go (hERG/Kv11.1) potassium, and human voltage-gated sodium (Nav) channel Nav1.5 (IC50s = 32, 7.8, and 100 μM, respectively). Z944 (30 mg/kg) reduces the seizure duration and the amount of time rats spend in seizures in a model of absence epilepsy. It delays seizure progression in amygdala-kindled rats but does not inhibit seizures in fully kindled rats.
용도As N-Piperidinyl acetamide derivatives, N-((1-(2-(tert-ButylaMino)-2-oxoethyl)piperidin-4-yl)Methyl)-3-chloro-5-fluorobenzaMide can be used as calcium channel blockers and their use in the treatment of obesity.
공급사43 곳
天津欣康佑生物科技有限公司19922659386 19922659386 · [email protected]
Career Henan Chemica Co+86-0371-86658258 +86-13203830695 · [email protected]
上海毕得医药科技股份有限公司400-1647117 13681763483 · [email protected]
上海冬洋生物科技有限公司0512-13601744364 13601744364 · [email protected]
江苏艾康生物医药研发有限公司025-025-66113011 15955137747 · [email protected]
梯希爱（上海）化工贸易有限公司021-61109150 · [email protected]
United Life Science020-82099279 18988968278 · [email protected]
上海瀚香生物科技有限公司177-54423994 17754423994 · [email protected]
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