로독사미드트로메타민
로독사미드트로메타민 · AloMide · AlMide · U-42585-E · LodoxaMide troMetaMol · Lodoxamidetromethamine · Lodoxamide Tromethamide · LodoxaMide troMethaMineon
식별자 및 물리적 특성
| CAS No. | 63610-09-3 |
|---|---|
| 분자식 | C15H17ClN4O9 |
| 평균 분자량 | 432.77 g/mol |
| 단동위원소 질량 | 432.0684058 g/mol |
| SMILES | N#Cc1cc(NC(=O)C(=O)O)c(Cl)c(NC(=O)C(=O)O)c1.NC(CO)(CO)CO |
| InChIKey | KUGJPYZIWCRREB-UHFFFAOYSA-N |
| PubChem CID | 44563 |
| ChEMBL | CHEMBL1201175 |
| DTXSID | DTXSID20979825 |
| 현지명 | 로독사미드트로메타민 |
화학 및 물리적 성질
| 극성 표면적 | 243 |
|---|---|
| 수소 결합 공여자 수 | 8 |
| 수소 결합 수용자 수 | 11 |
| 회전 가능 결합 수 | 7 |
| 무거운 원자 수 | 29 |
| 형식 전하 | 0 |
| 복잡도 | 543 |
| 저장 조건 | under inert gas (nitrogen or Argon) at 2–8 °C |
| 용해도 | DMSO: 20 mg/mL (36.11 mM and warming) |
| 물리적 상태 | Solid |
| 색상 | White to light yellow |
안전 및 규제
| 신호 어 | Warning |
|---|---|
| 유해·위험 문구 | 암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드 H302 |
용도
개요
Lodoxamide tromethamine was launched as an ophthalmic formulation for the treatment of allergic conjunctivitis. It appears to act as a mast cell stabilizer inhibiting degranulation and the release of histamine and other vasoactive products in a similar manner to sodium cromoglycate. The compound is also under investigation as an orally active antiallergic/antiasthmatic agent.
용도
cataract treatment
일반 설명
Lodoxamidetromethamine, N, N -(2-chloro-5-cyano-m-phenylene)dioxamicacid (Alomide), is a white crystalline, water-solublepowder. The only significant structural similarity betweenlodoxamide and cromolyn and nedocromil is the presence oftwo acidic groups. Lodoxamide is indicated in the treatmentof the ocular disorders including vernal keratoconjunctivitis,vernal conjunctivitis, and vernal keratitis. Lodoxamide isavailable as a 0.1% solution, with each milliliter containing1.78 mg of lodoxamide tromethamine equivalent to 1 mg oflodoxamide. The solution contains the preservative benzalkoniumchloride (0.007%) as well as mannitol, hydroxypropylmethylcellulose, sodium citrate, citric acid, edetatedisodium, tyloxapol, hydrochloric acid and/or sodium hydroxide(to adjust pH), and purified water.The dose for adults and children older than 2 years of ageis 1 to 2 drops in each affected eye 4 times daily for up to 3months. The most frequently reported ocular adverse experienceswere transient burning, stinging, or discomfort oninstillation.