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기본 정보
- CAS
436159-64-7- 표준 SMILES
CCC(=O)NC[C@H](Cc1ccc(OCCc2nc(-c3ccccc3)oc2C)cc1)N/C(C)=C\C(=O)c1ccc(C(F)(F)F)cc1- InChIKey
TYEFSRMOUXWTDN-DYQICHDWSA-N- 분자식
- C35H36F3N3O4
- 평균 분자량
- 619.684 g/mol
- 단동위원소 질량
- 619.26579129
이름 및 식별자
- 우선 이름
- GW6471
- IUPAC
- N-[(2S)-3-{4-[2-(5-Methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl}-2-({(2Z)-4-oxo-4-[4-(trifluoromethyl)phenyl]but-2-en-2-yl}amino)propyl]propanamide
- 영어명
- GW 6471
- 분자식
- C35H36F3N3O4
- 분자량
- 619.67
이름 및 동의어
GW 6471GW 6471 USP/EP/BPGW6471, 10 mM in DMSOGW 6471, PPAR alpha antagonist(S,Z)-N-(3-(4-(2-(5-Methyl-2-phenyloxazol-4-yl)ethoxy)phenyl)-2-((4-oxo-4-(4-(trifluoromethyl)phenyl)but-2-en-2-yl)amino)propyl)propionamideN-[(2S)-3-{4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl}-2-{[(2Z)-4-oxo-4-[4-(trifluoromethyl)phenyl]but-2-en-2-yl]amino}propyl]propanamideN-((2S)-2-(((1Z)-1-METHYL-3-OXO-3-(4-(TRIFLUOROMETHYL)PHENYL)PROP-1-ENYL)AMINO)-3-(4-(2-(5-METHYL-2-PHENYL-1,3-OXAZOL-4-YL)ETHOXY)PHENYL)PROPYL)PROPANAMIDEPropanamide, N-[(2S)-2-[[(1Z)-1-methyl-3-oxo-3-[4-(trifluoromethyl)phenyl]-1-propen-1-yl]amino]-3-[4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]propyl]-[(2S)-2-[[(1Z)-1-METHYL-3-OXO-3-[4-(TRIFLUOROMETHYL)PHENYL]-1-PROPENYL]AMINO]-3-[4-[2-(5-METHYL-2-PHENYL-4-OXAZOLYL)ETHOXY]PHENYL]PROPYL]-CARBAMIC ACID ETHYL ESTER
데이터베이스 식별자
- CAS
436159-64-7、880635-03-0- PubChem CID
- 446738
- DTXSID
DTXSID601014896- ChEMBL
CHEMBL500272- EC Number
- 636-961-3、804-305-7
- Nikkaji
물성
물리화학적 성질
- 밀도
- 1.204 · 1.204±0.06 g/cm3(Predicted)
- 저장 조건
- 2 · 2-8°C
- 용해도
- 15 mg/mL · DMSO: 15mg/mL
- 물리적 상태
- 고체
- 산도 계수 (pKa)
- 15.9 · 15.90±0.46(Predicted)
- 색상
- 회백색
- InChIKey
- TYEFSRMOUXWTDN-DYQICHDWSA-N
- SMILES
- C(NC[C@@H](N/C(/C)=C\C(=O)C1=CC=C(C(F)(F)F)C=C1)CC1=CC=C(OCCC2=C(C)OC(C3=CC=CC=C3)=N2)C=C1)(=O)CC
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
안전 데이터
- wgk
- 3
- risk_code
- 36/37/38
- hazard_code
- Xi
- safety_code
- 26-36
- 스토리지 클래스
- 11 - Combustible Solids
화학 및 산업
응용 분야
용도GW 6471 is a peroxisome proliferator-activated receptor α (PPARα) antagonist. GW 6471 has been shown to enhance the binding affinity of the PPARα ligand-binding domain to the co-repressor proteins SMRT and NCoR.
일반 설명GW6471 prevents apoptosis and cell cycle arrest at G0/G1 in renal cell carcinoma. It reduces enhanced fatty acid oxidation and oxidative phosphorylation associated with glycolysis inhibition.
공급사6 곳
武汉易泰科技有限公司上海分公司18930552037 · [email protected]
上海瀚香生物科技有限公司177-54423994 17754423994 · [email protected]
AdooQ BioScience, LLC+1 (866) 930-6790 · [email protected]
Sigma-Aldrich西格玛奥德里奇(上海)贸易有限公司021-61415566 800-8193336 · [email protected]
上海芮晖化工科技有限公司021-31433387 15618786686 · [email protected]
上海临卡生物科技有限公司18301977208 · [email protected]
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