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기본 정보
- CAS
1189889-44-8- 표준 SMILES
[2H]C([2H])([2H])n1c(-c2cc(C)c3nc(CCC)n(Cc4ccc(-c5ccccc5C(=O)O)cc4)c3c2)nc2ccccc21- InChIKey
RMMXLENWKUUMAY-HPRDVNIFSA-N- 분자식
- C33H30N4O2
- 평균 분자량
- 517.6473 g/mol
- 단동위원소 질량
- 517.25570644
이름 및 식별자
- 우선 이름
- Telmisartan-d3
- IUPAC
- 4'-{[7'-Methyl-1-(~2~H_3_)methyl-2'-propyl-1H,3'H-[2,5'-bibenzimidazol]-3'-yl]methyl}[1,1'-biphenyl]-2-carboxylic acid
- 현지명
- 텔미사르탄-D3
- 영어명
- TELMISARTAN-D3
- 분자식
- C33H27D3N4O2
- 분자량
- 517.64
이름 및 동의어
텔미사르탄-D3Pritor-d3BIBR 277-d3Micardis-d3BIBR 277SE-d3TELMISARTAN-D3D3-TelmisartanTelmisartan-d3 in methanol4'-[(1,4'-DiMethyl-2'-propyl[2,6'-bi-H-benziMidazol]-1'-yl)Methyl][1,1'-biphenyl]-2-carboxylic Acid-d34'-[[4-Methyl-6-(1-Methyl-2-benziMidazolyl)-2-propyl-1-benziMidazolyl] Methyl]-2-biphenylcarboxylic Acid-d34'-({4-methyl-6-[1-(2H?)methyl-1H-1,3-benzodiazol-2-yl]-2-propyl-1H-1,3-benzodiazol-1-yl}methyl)-[1,1'-biphenyl]-2-carboxylic acid
데이터베이스 식별자
- CAS
1189889-44-8- PubChem CID
- 45040461
- DTXSID
DTXSID70662199
물성
물리화학적 성질
- 녹는점
- 262 · 262-265°C
- 저장 조건
- -20 °C · -20°C Freezer, Under Inert Atmosphere
- 용해도
- DMSO(약간 용해됨), 메탄올(약간 용해됨, 가열)
- 물리적 상태
- 고체
- 색상
- 흰색에서 베이지색
화학적 성질
Off-White Crystalline Solid
화학 및 산업
응용 분야
개요Telmisartan-d3 is intended for use as an internal standard for the quantification of telmisartan by GC- or LC-MS. Telmisartan is a nonpeptide angiotensin (AT) II receptor antagonist which selectively and insurmountably inhibits the AT II receptor subtype AT1 (Ki = 3.7 nM). It also acts as a partial agonist of peroxisome proliferator-activated receptor gamma (PPARγ), activating the receptor to 25-30% of that produced by the full agonist rosiglitazone (; EC50 = 4.5 μM). Through these actions, telmisartan potently reduces blood pressure in various animal models of hypertension, diminishing cardiac hypertrophy, cardiovascular and renal risk, and glomerulosclerosis.
용도TelMisartan-d3 is an angiotensin II receptor antagonist.
공급사37 곳
艾吉析科技（上海）有限公司17717235263 · [email protected]
广州佳途科技股份有限公司81960175-877 18933936954 · [email protected]
杭州摩库生物医药科技有限公司+86-057181025280; +8617767106207 · [email protected]
上海赛可锐生物科技有限公司021-58000709 13120558703 · [email protected]
Aladdin Scientific[email protected]
Sinco Pharmachem (ShenZhen) R&D Co., Ltd.+86-18603013401 · [email protected]
山东大有药物研发有限公司[email protected] 15165037910 · [email protected]
成都梓永智研生物科技有限公司17780686372 · [email protected]
上海稳同科技有限公司02151600108 13062666369 · [email protected]
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