Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Oxazolam
oxazolam · Nebusn · Toccata · Serenal · Tranquit · Hializan · Oxazolazepam · Serenal (Japanese)
식별자 및 물리적 특성
| CAS No. | 24143-17-7 |
|---|---|
| 분자식 | C18H17ClN2O2 |
| 평균 분자량 | 328.8 g/mol |
| 단동위원소 질량 | 328.0978555 g/mol |
| SMILES | CC1CN2CC(=O)Nc3ccc(Cl)cc3C2(c2ccccc2)O1 |
| InChIKey | VCCZBYPHZRWKFY-UHFFFAOYSA-N |
| PubChem CID | 4617 |
| ChEMBL | CHEMBL2104805 |
| ChEBI | CHEBI:31944 |
| EC No. | 246-032-0 |
| DTXSID | DTXSID5023401 |
화학 및 물리적 성질
| XLogP | 3 |
|---|---|
| 극성 표면적 | 41.6 |
| 수소 결합 공여자 수 | 1 |
| 수소 결합 수용자 수 | 3 |
| 회전 가능 결합 수 | 1 |
| 무거운 원자 수 | 23 |
| 형식 전하 | 0 |
| 복잡도 | 468 |
| Kovats Retention Index | 25642569258625962590 |
| 녹는점 | 187°C |
| 끓는 점 | 495.8±45.0 °C(Predicted) |
| 밀도 | 1.2065 (rough estimate) |
| 굴절률 | 1.5400 (estimate) |
| 인화점 | 11 °C |
| 저장 조건 | 2-8°C |
| 용해도 | 클로로포름(약간 용해됨), 메탄올(약간 용해됨) |
| pKa(산도 계수) | 12.85±0.60(Predicted) |
| 물리적 상태 | 고체 |
안전 및 규제
| GHS 분류 | DangerH301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]H331 (100%): Toxic if inhaled [Danger Acute toxicity, inhalation]P261, P264, P264+P265, P270, P271, P280, P301+P316, P302+P352, P304+P340, P305+P351+P338, P316, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 39 reports by companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. |
|---|---|
| 규제 정보 | DEA schedule IV controlled substance |
| Hazard Classes and Categories | Acute Tox. 3 (100%)Skin Irrit. 2 (100%)Eye Irrit. 2 (100%) |
| Treatment | General supportive measures should be employed, along with intravenous fluids, and an adequate airway maintained. Hypotension may be combated by the use of norepinephrine or metaraminol. Dialysis is of limited value. Flumazenil (Anexate) is a competitive benzodiazepine receptor antagonist that can be used as an antidote for benzodiazepine overdose. In particular, flumazenil is very effective at reversing the CNS depression associated with benzodiazepines but is less effective at reversing respiratory depression. Its use, however, is controversial as it has numerous contraindications. It is contraindicated in patients who are on long-term benzodiazepines, those who have ingested a substance that lowers the seizure threshold, or in patients who have tachycardia or a history of seizures. As a general rule, medical observation and supportive care are the mainstay of treatment of benzodiazepine overdose. Although benzodiazepines are absorbed by activated charcoal, gastric decontamination with activated charcoal is not beneficial in pure benzodiazepine overdose as the risk of adverse effects often outweigh any potential benefit from the procedure. It is recommended only if benzodiazepines have been taken in combination with other drugs that may benefit from decontamination. Gastric lavage (stomach pumping) or whole bowel irrigation are also not recommended. |
용도
용도
A psychotropic agent with anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties. It is a precursor to the active substance Desmethyldiazepam (D291595).