기본 정보
- CAS
125-53-1- 표준 SMILES
CN1CCCN=C1COC(=O)C(O)(c1ccccc1)C1CCCCC1- InChIKey
DUDKAZCAISNGQN-UHFFFAOYSA-N- 분자식
- C20H28N2O3
- 평균 분자량
- 344.4 g/mol
- 단동위원소 질량
- 344.20999276
개요
Oxyphencyclimine is a monocarboxylic acid.
이름 및 식별자
- 우선 이름
- Oxyphencyclimine
- IUPAC
- (1-methyl-5,6-dihydro-4H-pyrimidin-2-yl)methyl 2-cyclohexyl-2-hydroxy-2-phenylacetate
- 현지명
- 옥시펜시클린
- 영어명
- oxyphencyclimine
- 분자식
- C20H28N2O3
- 분자량
- 344.45
이름 및 동의어
oxyphencyclimine125-53-1Oxyphencycliminumoxifenciclimina4V44H1O8XI(1-methyl-1,4,5,6-tetrahydropyrimidin-2-yl)methyl 2-cyclohexyl-2-hydroxy-2-phenylacetateDTXSID4023410RefChem:169068DTXCID403410A03AA01Benzeneacetic acid, alpha-cyclohexyl-alpha-hydroxy-, (1,4,5,6-tetrahydro-1-methyl-2-pyrimidinyl)methyl ester204-743-3
이름 더 보기
옥시펜시클린ManirC07851ZamanilNaridan1,4,5,6-Tetrahydro-1-methyl-2-pyrimidinemethanol alpha-phenylcyclohexaneglycolate (ester)Benzeneacetic acid, α-cyclohexyl-α-hydroxy-, (1,4,5,6-tetrahydro-1-methyl-2-pyrimidinyl)methyl ester
AntulcusOxiphencycliminumOxyphencycliminum [INN-Latin]Oxifencicliminum [INN-Spanish](1-methyl-5,6-dihydro-4H-pyrimidin-2-yl)methyl 2-cyclohexyl-2-hydroxy-2-phenylacetateOxyphencyclimine (INN)Benzeneacetic acid, .alpha.-cyclohexyl-.alpha.-hydroxy-, (1,4,5,6-tetrahydro-1-methyl-2-pyrimidinyl)methyl esterCaridan
물성
구조 계산 물성
- XLogP
- 2.9
- 극성 표면적
- 62.1 Ų
- 수소 결합 공여자 수
- 1
- 수소 결합 수용자 수
- 4
- 회전 가능 결합 수
- 6
- 무거운 원자 수
- 25
- 형식 전하
- 0
- 복잡도
- 481
실험 및 물리화학적 성질
LogP3.7
Solubility5.67e-02 g/L
Human DrugsPharmaceuticals
Physical DescriptionSolid
Collision Cross Section180.99 Ų [M+Na]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
유해성 정보
Other Safety InformationIMAP assessments - Benzeneacetic acid, .alpha.-cyclohexyl-.alpha.-hydroxy-, (1,4,5,6-tetrahydro-1-methyl-2-pyrimidinyl)methyl ester: Environment tier I assessment
화학 및 산업
약리 정보
ATC Code
A - Alimentary tract and metabolism
QA - Alimentary tract and metabolism
Pharmacodynamics
Oxyphencyclimine is a synthetic anticholinergic agent which has been shown in experimental and clinical studies to have a pronounced antispasmodic and antisecretory effect on the gastrointestinal tract. Oxyphencyclimine is an antimuscarinic, anticholinergic drug.
Mechanism of Action
Oxyphencyclimine binds the muscarinic acetylcholine receptor. It may block all three types of muscarinic receptors including M-1 receptors in the CNS and ganglia, M-2 receptors in the heart (vagus) and M-3 receptors at the parasympathetic NEJ system. The muscarinic acetylcholine receptors mediate various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Oxphencyclimine inhibits vagally mediated reflexes by antagonizing the action of acetylcholine. This in turn reduces the secretion of gastric acids in the stomach.
Cellular LocationsMembrane
용도 및 제조
Use ClassificationPharmaceuticals
상·하류 제품 정보
상류 원료
공급사9 곳
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