팔미타마이드엠이에이

팔미타마이드엠이에이 · 팔미토일레타놀라미드 · Palmidrol · Palmitic acid monoethanolamide · N-palmitoylethanolamine · PALMITAMIDE MEA · N-(2-Hydroxyethyl)palmitamide · N-(2-HYDROXYETHYL)HEXADECANAMIDE

https://huagongshe.com/ko/chemical/4671

식별자 및 물리적 특성

CAS No.	544-31-0
분자식	C18H37NO2
평균 분자량	299.5 g/mol
단동위원소 질량	299.28242942 g/mol
SMILES	CCCCCCCCCCCCCCCC(=O)NCCO
InChIKey	HXYVTAGFYLMHSO-UHFFFAOYSA-N
PubChem CID	4671
ChEMBL	CHEMBL417675
ChEBI	CHEBI:71464
EC No.	208-867-9
DTXSID	DTXSID4042254
현지명	팔미타마이드엠이에이

화학 및 물리적 성질

XLogP	6.2
극성 표면적	49.3
수소 결합 공여자 수	2
수소 결합 수용자 수	2
회전 가능 결합 수	16
무거운 원자 수	21
형식 전하	0
복잡도	219
의약품	Pharmaceuticals -> Listed in ZINC15
지질	Lipids -> Unambiguous LipidsFatty Acyls [FA] -> Fatty amides [FA08] -> N-acyl ethanolamines (endocannabinoids) [FA0804]
화장품	Cosmetic ingredients (Palmitamide MEA) -> CIR (Cosmetic Ingredient Review)Foam boostingViscosity controllingAntistaticPersonal care product
녹는점	98.5 °C97-98℃
Physical Description	Other Solid
Collision Cross Section	189.0 Å² [M+H]+ [CCS Type: DTBuffer gas: N2Sample Type: Human plasmaDataset: Unambiguous Lipids]189.87 Å² [M+H]+ [CCS Type: TIMSMethod: single field calibrated]
끓는 점	461.5±28.0 °C(Predicted)
밀도	0.910±0.06 g/cm3(Predicted)
증기압	0.45Pa at 20℃
저장 조건	-20°C
용해도	DMSO(최대 25mg/ml) 또는 에탄올(최대 25mg/ml)에 용해됩니다.
물리적 상태	흰색 고체
pKa(산도 계수)	14.49±0.10(Predicted)
색상	하얀색
용해도	4.01mg/L at 20℃
안정성	제공된 대로 구매일로부터 2년 동안 안정적입니다. DMSO 또는 에탄올 용액은 -20°에서 최대 3개월 동안 보관할 수 있습니다.
화장품 원료 기능	계면활성제 - 거품 증진제대전방지제점도 조절
InChI	1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)19-16-17-20/h20H,2-17H2,1H3,(H,19,21)
InChIKey	HXYVTAGFYLMHSO-UHFFFAOYSA-N
SMILES	N(CCO)C(=O)CCCCCCCCCCCCCCC
LogP(분배 계수)	3.989 at 20℃
EPA	Palmitoylethanolamide (544-31-0)

화학적 성질

Palmitoylethanolamide is a natural occurring lipid belonging to the class of autacoids. It is a fine white to yellow powder. PEA consists of palmitic acid and ethanolamine. It is the hydrolyzed form of N-(2-hydroxyethyl)-palmitamide, a crystalline structure isolated in soy lecithin. It is this hydrolyzed substance that accounts for the anti-inflammatory properties that were first noted by scientists in 1957. PEA's effects on the immune system have been studied since 1939.

안전 및 규제

GHS 분류	This chemical does not meet GHS hazard criteria for 2.5% (4 of 162) of reports.DangerH315 (97.5%): Causes skin irritation [Warning Skin corrosion/irritation]P264, P264+P265, P273, P280, P302+P352, P305+P354+P338, P317, P321, P332+P317, P362+P364, P391, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 162 reports by companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
규제 정보	Hexadecanamide, N-(2-hydroxyethyl)- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Hexadecanamide, N-(2-hydroxyethyl)- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)Status: Active Update: 12-01-2021 https://echa.europa.eu/registration-dossier/-/registered-dossier/23420
Hazard Classes and Categories	Skin Irrit. 2 (97.5%)
독성 요약	The CIR Expert Panel concluded that the ethanolamides listed subsequently are safe in the present practices of use and concentration described in this safety assessment when formulated to be non-irritating. The Expert Panel cautioned that these ingredients should not be used in cosmetic products in which N-nitroso compounds may be formed...Palmitamide MEA...Safe for use in cosmetics, with qualifications
수질 위해 등급(WGK)	2
TSCA 등재 상태	TSCA listed
운송 번호(UN)	UN3077
관세 코드	2934.99.4400
위험 등급	9Aquatic Chronic 2Eye Dam. 1Skin Irrit. 2
저장 분류	13 - Non Combustible Solids

용도

개요

Palmitoylethanolamide (PEA) is a fatty acid amide produced in the body that binds to and activates the peroxisome proliferator-activated receptor alpha (PPAR-α). It was initially described as an agonist to the type 2 cannabinoid receptor (CB2), though it is now recognized that PEA does not bind to cannabinoid receptors. PEA is known to have anti-inflammatory, analgesic, and neuroprotective properties. PEA supplements have been used by people with chronic pain as well as those with neuropathic pain.

용도

Palmitoylethanolamide is a natural substance produced by the body and it is very effective and safe to use as a supplement for pain and reduce inflammation.PEA can be synthesized within the human body from the abundant fatty acid palmitic acid, but it is not dependent or influenced by dietary consumption of fatty acids. Palmitic acid in the diet is derived from dairy products such as cheese and butter, palm tree oil, and animal meat products. However, increasing palmitic acid in the hope of increasing endogenous PEA synthesis will not be effective.The anti-inflammatory properties of PEA are due to its ability to inhibit inflammation-causing proteins called cytokines. Cytokines are released during periods of inflammation. PEA can suppress the secretion of tumor necrosis factor alpha (TNF alpha), a cytokine, while also inhibiting the release of interleukins. Interleukins are a specific class of cytokines which belong in the immunological system and are activated during the process of inflammation.Chronic Pain and the Use of Palmitoylethanolamide: An Update