Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Paxillin
PAXILINE · mycillin · PAXILLINE · Paxicillin · Paxilline solution · Paxilline in Methanol · fromPenicilliumpaxilli · PAXILLINE, PENICILLIUM PAXILLI
식별자 및 물리적 특성
| CAS No. | 57186-25-1 |
|---|---|
| 분자식 | C27H33NO4 |
| 평균 분자량 | 435.6 g/mol |
| 단동위원소 질량 | 435.24095853 g/mol |
| SMILES | CC(C)(O)C1OC2CCC3(C)C(O)(CCC4Cc5c([nH]c6ccccc56)C43C)C2=CC1=O |
| InChIKey | ACNHBCIZLNNLRS-UHFFFAOYSA-N |
| PubChem CID | 4697 |
화학 및 물리적 성질
| XLogP | 3.5 |
|---|---|
| 극성 표면적 | 82.6 |
| 수소 결합 공여자 수 | 3 |
| 수소 결합 수용자 수 | 4 |
| 회전 가능 결합 수 | 1 |
| 무거운 원자 수 | 32 |
| 형식 전하 | 0 |
| 복잡도 | 868 |
| 인화점 | 2℃ |
| 저장 조건 | 2-8°C |
| 용해도 | DMSO, 아세톤 또는 클로로포름에 용해됩니다. |
| 물리적 상태 | 가루 |
| 색상 | 희미한 노란색 |
| 주요 응용 | 청소용품화장품음식 및 음료개인 위생 관리 |
| InChIKey | ACNHBCIZLNNLRS-UBGQALKQSA-N |
| SMILES | N1C2=C(C=CC=C2)C2C[C@@]3([H])[C@](C)(C1=2)[C@@]1(C)CC[C@]2([H])O[C@H](C(O)(C)C)C(=O)C=C2[C@]1(O)CC3 |
화학적 성질
Powder
안전 및 규제
| Treatment | To control severe tremors caused by tremorgenic mycotoxins, methocarbamol should be administered. Generalized seizures may be treated with diazepam followed by methocarbamol or a barbiturate such as pentobarbital sodium. Gastric lavage should be performed and activated charcoal administered to limit further absorption of toxins. (A744) |
|---|---|
| 건강 영향 | Tremorgenic mycotoxins affect central nervous system activity. They cause a neurological disease of cattle known as "staggers syndrome". (A2976) |
| 노출 경로 | Oral, dermal, inhalation, and parenteral (contaminated drugs). (A3101) |
| 독성 요약 | Tremorgenic mycotoxins exert their toxic effects by interfering with neurotransmitter release, possibly by causing degeneration of nerve terminals. They are thought to inhibit gamma-aminobutyric acid (GABA) receptors, both pre- and postsynaptic, as well as inhibit transmitter breakdown at the GABA-T receptors. This would initially increase neurotransmitter levels, potentiating the GABA-induced chloride current, then lead to decreased levels of neurotransmitter in the synapse. In addition, paxilline inhibits presynaptic high-conductance Ca+2 activated maxi-K+ channels in the smooth muscle. Paxilline is also genotoxic and causes DNA damage. (A2976, A2993, A3026) |
| Signs and Symptoms | Tremorgenic mycotoxins affect central nervous system activity, inducing neurologic symptoms including mental confusion, paralysis, tremors, seizures, and death. They cause a neurological disease of cattle known as "staggers syndrome", which is characterized by muscle tremors, hyperexcitability, convulsions and ataxia. (A2976) |
| Carcinogen Classification | No indication of carcinogenicity to humans (not listed by IARC). |
| 수질 위해 등급(WGK) | 3 |
| RTECS 번호 | DJ2830000 |
| 운송 번호(UN) | UN 2811 6.1/PG 3 |
| 관세 코드 | 29419090 |
| 위험 문구(R) | 23/24/25-36/37/38-41-36-20/21/22-11 |
| 위험 표시 | T,Xn,F |
| 안전 문구(S) | 26-36/37/39-45-36/37-16 |
| 포장분류 |
용도
개요
A complex alkaloid, paxilline occurs in the mycelium of the mold Penicillium paxilli. The structure has been confirmed by X-ray crystallography. The crystals are orthorhombic with space group P2 12 121 and a = 31.009, b = 11.522 and c = 7.70 A.
용도
Paxilline is a tremorgenic mycotoxin isolated from species of Penicillium, Acremonium and Emericella. Paxilline selectively blocks high-conductance Ca2+-activated potassium channels and inhibits binding to the cerebellar inositol 1,4,5-triphosphate (InsP(3)) receptor.