기본 정보
- CAS
64118-86-1- 표준 SMILES
CC(C)(N1CC1C#N)N1CC1C(N)=O- InChIKey
RPZOFMHRRHHDPZ-UHFFFAOYSA-N- 분자식
- C9H14N4O
- 평균 분자량
- 194.23 g/mol
- 단동위원소 질량
- 194.11676108
개요
Azimexon is azimexon (2-cyanaziridinyl-2-carbamoyl-aziridinyl-1-propane) is a derivative of 2-cyanaziridine. Immunostimulant which shows therapeutic effects in tumor models and experimental infections in vitro, enhancing T lymphocyte transformation and phagocytosis. The mode of action of azimexon is unknown. It has been suggested that azimexon may alkylate DNA. In cancer patients it increases leukocytosis, blood active T rosettes, T4/T8 ratio, and is used as an adjuvant to chemotherapy in the treatment of melanoma and myeloma.
이름 및 식별자
- 우선 이름
- Azimexone
- IUPAC
- 1-[2-(2-cyanoaziridin-1-yl)propan-2-yl]aziridine-2-carboxamide
- 현지명
- 아지멕손
- 영어명
- azimexon
- 분자식
- C9H14N4O
- 분자량
- 194.23
이름 및 동의어
Azimexon64118-86-1azimexoneAzimexonumBM-12531BM-12,5314NJ842U6BZ2-(2-Cyanaziridinyl-(1))-2-(2-carbamoylaziridinyl-(1))propaneBM12,531BM 12,5312-AZIRIDINECARBOXAMIDE, 1-(1-(2-CYANO-1-AZIRIDINYL)-1-METHYLETHYL)-2-Aziridinecarboxamide, 1-(1-(2-cyano-1-aziridinyl)-1-methylethyl)
이름 더 보기
아지멕손1-[1-(2-Cyano-1-aziridinyl)-1-methylethyl]-2-aziridinecarboxamide2-Aziridinecarboxamide, 1-[1-(2-cyano-1-aziridinyl)-1-methylethyl]-
2-Aziridinecarboxamide, 1-[1-(2-cyano-1-aziridinyl)-1-methylethyl]RefChem:116117BM12531BM 12.5312-Cyanaziridinyl-2-carbamoyl-aziridinyl-1-propane264-679-7Azimexon [INN]1-[2-(2-cyanoaziridin-1-yl)propan-2-yl]aziridine-2-carboxamide
데이터베이스 식별자
- CAS
64118-86-1- PubChem CID
- 47294
- DTXSID
DTXSID60867055- ChEMBL
CHEMBL149579- UNII
물성
구조 계산 물성
- XLogP
- -0.6
- 극성 표면적
- 72.9 Ų
- 수소 결합 공여자 수
- 1
- 수소 결합 수용자 수
- 4
- 회전 가능 결합 수
- 3
- 무거운 원자 수
- 14
- 형식 전하
- 0
- 복잡도
- 329
물리화학적 성질
- 녹는점
- 151 · 151-155 °C(Solv: acetone (67-64-1))
- 끓는 점
- 403.4 · 403.4±45.0 °C(Predicted)
- 밀도
- 1.29 · 1.29±0.1 g/cm3(Predicted)
- 산도 계수 (pKa)
- 16.09 · 16.09±0.20(Predicted)
화학 및 산업
약리 정보
MeSH Pharmacological Classification
Substances that augment, stimulate, activate, potentiate, or modulate the immune response at either the cellular or humoral level. The classical agents (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contain bacterial antigens. Some are endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Their mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy of many biological response modifiers is related to their antigen-specific immunoadjuvanticity.
공급사1 곳
上海昕凯医药科技有限公司21-619849051-1 18521059765 · [email protected]
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