Talwin

HCID 4736
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기본 정보

CAS
359-83-1
표준 SMILES
CC(C)=CCN1CCC2(C)c3cc(O)ccc3CC1C2C
InChIKey
VOKSWYLNZZRQPF-UHFFFAOYSA-N
분자식
C19H27NO
평균 분자량
285.4 g/mol
단동위원소 질량
285.20926449

개요

Talwin is a benzazocine.

이름 및 식별자

우선 이름
Talwin
IUPAC
1,13-dimethyl-10-(3-methylbut-2-enyl)-10-azatricyclo[7.3.1.02,7]trideca-2(7),3,5-trien-4-ol
영어명
1,2,3,4,5,6-hexahydro-6,11-dimethyl-3-(3-methylbut-2-enyl)-2,6-methano-3-benzazocin-8-ol
분자식
C19H27NO
분자량
285.42

이름 및 동의어

Talwin1,13-dimethyl-10-(3-methylbut-2-enyl)-10-azatricyclo[7.3.1.02,7]trideca-2(7),3,5-trien-4-ol1,13-dimethyl-10-(3-methylbut-2-enyl)-10-azatricyclo(7.3.1.02,7)trideca-2(7),3,5-trien-4-olRefChem:93253355643-30-6dl-PentazocineEINECS 259-735-2Sosegon1,2,3,4,5,6-Hexahydro-6,11-dimethyl-3-(3-methylbut-2-enyl)-2,6-methano-3-benzazocin-8-olCHEMBL100116PentazocaineKF-1820
이름 더 보기
VOKSWYLNZZRQPF-UHFFFAOYSA-N2,6-Methano-3-benzazocin-8-ol, 1,2,3,4,5,6-hexahydro-6,11-dimethyl-3-(3-methyl-2-buten-1-yl)-
2,6-Methano-3-benzazocin-8-ol, 1,2,3,4,5,6-hexahydro-6,11-dimethyl-3-(3-methyl-2-butenyl)-, (2.alpha.,6.alpha.,11R*)-PENTAZOCINE (+)PENTAZOCINE (-)SosetonTalwan39188-58-4Algopent (free base)(.+/-.)-Pentazocine

데이터베이스 식별자

CAS
359-83-1、39188-58-4、55643-30-6、7488-49-5
PubChem CID
4736
DTXSID
DTXSID30859346
ChEMBL
CHEMBL100116
ChEBI
CHEBI:182080
EC Number
259-735-2、811-426-9
Nikkaji
J267.040B

물성

구조 계산 물성

XLogP
3.3
극성 표면적
23.5 Ų
수소 결합 공여자 수
1
수소 결합 수용자 수
2
회전 가능 결합 수
2
무거운 원자 수
21

실험 및 물리화학적 성질

Human DrugsBreast Feeding; Lactation; Milk, Human; Analgesics, Opioid; Narcotics; Narcotic Antagonists; Opiates
Dissociation Constants8.88
Collision Cross Section173.5 Ų [M+H]+ [CCS Type: TW; Method: Major Mix IMS/Tof Calibration Kit (Waters)]

안전 및 규제

GHS 분류

GHS Classification · 4건

Warning

H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]

P264, P270, P301+P317, P330, and P501 (click each P-code to see the statement)

The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

유해성 정보

Hazard Classes and CategoriesAcute Tox. 4 (100%)

독성 정보

Treatment · 1건

Adequate measures to maintain ventilation and general circulatory support should be employed. Assisted or controlled ventilation, intravenous fluids, vasopressors, and other supportive measures should be employed as indicated. Consideration should be given to gastric lavage and gastric aspiration. For respiratory depression due to overdosage or unusual sensitivity to pentazocine, parenteral naloxone is a specific and effective antagonist. Initial doses of 0.4 to 2.0 mg of naloxone are recommended, repeated at 2-3 minute intervals, if needed, up to a total of 10 mg. Anti

Health EffectsMedical problems can include congested lungs, liver disease, tetanus, cardiovascular effects, infection of the heart valves, skin abscesses, anemia and pneumonia. Death can occur from overdose.
Exposure RoutesIntravenous, Oral. Well absorbed from the gastro-intestinal tract.
Toxicity SummaryThe preponderance of evidence suggests that pentazocine antagonizes the opioid effects by competing for the same receptor sites, especially the opioid mu receptor.
Signs and Symptomshallucinations and other psychotomimetic effects; cardiovascular effects
Carcinogen ClassificationNo indication of carcinogenicity to humans (not listed by IARC).

화학 및 산업

약리 정보

Pharmacodynamics · 1건

Pentazocine is a potent analgesic which when administered orally in a 50 mg dose appears equivalent in analgesic effect to 60 mg (1 grain) of codeine. Onset of significant analgesia usually occurs between 15 and 30 minutes after oral administration, and duration of action is usually three hours or longer. Onset and duration of action and the degree of pain relief are related both to dose and the severity of pretreatment pain. Pentazocine weakly antagonizes the analgesic effects of morphine and meperidine; in addition, it produces incomplete reversal of cardiovascular, respiratory, and behavioral depression induced by morphine and meperidine. Pentazocine has about 1/50 the antagonistic activity of nalorphine. It also has sedative activity.

Mechanism of ActionThe preponderance of evidence suggests that pentazocine antagonizes the opioid effects by competing for the same receptor sites, especially the opioid mu receptor.
Biological Half-Life2 to 3 hours
Metabolism/Metabolites · 2건

Hepatic

Hepatic Half Life: 2 to 3 hours

MeSH Pharmacological Classification · 4건

Compounds with activity like OPIATE ALKALOIDS, acting at OPIOID RECEPTORS. Properties include induction of ANALGESIA or NARCOSIS.

Agents that are administered in association with anesthetics to increase effectiveness, improve delivery, or decrease required dosage.

Agents inhibiting the effect of narcotics on the central nervous system.

Agents that induce NARCOSIS. Narcotics include agents that cause somnolence or induced sleep (STUPOR); natural or synthetic derivatives of OPIUM or MORPHINE or any substance that has such effects. They are potent inducers of ANALGESIA and OPIOID-RELATED DISORDERS.

Absorption, Distribution and ExcretionWell absorbed from the gastro-intestinal tract.

용도 및 제조

UsesUsed to treat mild to moderately severe pain. [Wikipedia]

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