기본 정보
- CAS
64953-12-4- 표준 SMILES
COC1(NC(=O)C(C(=O)[O-])c2ccc(O)cc2)C(=O)N2C(C(=O)[O-])=C(CSc3nnnn3C)COC21.[Na+].[Na+]- InChIKey
GRIXGZQULWMCLU-UHFFFAOYSA-L- 분자식
- C20H18N6Na2O9S
- 평균 분자량
- 564.4 g/mol
- 단동위원소 질량
- 564.06513591
개요
The sodium salts of the fatty acids in cod liver oil; an irritant and sclerosing agent used to treat varicose veins and arthritic joints.
이름 및 식별자
- 우선 이름
- Sodium Morrhuate
- IUPAC
- disodium;7-[[2-carboxylato-2-(4-hydroxyphenyl)acetyl]amino]-7-methoxy-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
- 영어명
- Latamoxef sodium
- 분자식
- C20H21N6NaO9S
- 분자량
- 544.47
이름 및 동의어
morruato de sodioMorrhuate, SodiumSodium, Morrhuate8031-09-2RefChem:183989DTXSID901057205652U49DZTPMorrhuate de sodiumMorrhuate SodiumMorrhuate sodium (USP)Natrii morrhuasSodium Morrhuate
이름 더 보기
6059smoxamS 6059ly127935LY 12735HY-B1484ShiomarinFestamoxinFestamoxinLyShionogi 6059S
latamoxef sodium64953-12-4Moxalactam sodium saltSCHEMBL7193337-[[Carboxy(4-hydroxyphenyl)acetyl]amino]-7-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-oxa-1-azabicyclo[4.2.o]oct-2-ene-2-carboxylic acid, disodium salts4986AKOS040758971PD117912
데이터베이스 식별자
- CAS
64953-12-4、8031-09-2- PubChem CID
- 47500
- ChEMBL
CHEMBL2109139- EC Number
- 265-288-4
물성
구조 계산 물성
- 극성 표면적
- 237 Ų
- 수소 결합 공여자 수
- 2
- 수소 결합 수용자 수
- 13
- 회전 가능 결합 수
- 7
- 무거운 원자 수
- 38
- 형식 전하
- 0
- 복잡도
- 947
물리화학적 성질
- 녹는점
- 156 oC · >156oC (dec.)
- 저장 조건
- 2 · Inert atmosphere,2-8°C
- 용해도
- 메탄올(약간)에 용해됨
- 물리적 상태
- 흰색에서 옅은 노란색까지
- 색상
- White to off-white
- Merck
- 13 · 13,6311
- 안정성
- 용액에서 불안정함(DMSO 또는 메탄올)
- 주요 응용
- 법의학 및 독성학수의사
- InChIKey
- GRIXGZQULWMCLU-GDUWRUPCSA-L
- SMILES
- N([C@@]1(C(=O)N2C(=C(CSC3=NN=NN3C)CO[C@]12[H])C(=O)O)OC)C(=O)[C@@H](C1C=CC(O)=CC=1)C(=O)O.[NaH] |&1:1,17,26,r|
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
GHS 분류
GHS Classification
Danger
H317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin]
P233, P260, P261, P271, P272, P280, P284, P302+P352, P304+P340, P321, P333+P317, P342+P316, P362+P364, P403, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 40 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
유해성 정보
Other Safety InformationIMAP assessments - 5-Oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[carboxy(4-hydroxyphenyl)acetyl]amino]-7-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-, disodium salt: Environment tier I assessment
Hazard Classes and CategoriesSkin Sens. 1 (100%)
안전 데이터
- wgk
- 2
- rtecs
- RN6824000
- risk_code
- 42/43
- hazard_code
- Xn
- safety_code
- 22-36/37-45
- Hazard Classifications
- Resp. Sens. 1Skin Sens. 1
- 스토리지 클래스
- 11 - Combustible Solids
화학 및 산업
약리 정보
MeSH Pharmacological Classification
Chemical agents injected into blood vessels and lymphatic sinuses to shrink or cause localized THROMBOSIS; FIBROSIS, and obliteration of the vessels. This treatment is applied in a number of conditions such as VARICOSE VEINS; HEMORRHOIDS; GASTRIC VARICES; ESOPHAGEAL VARICES; PEPTIC ULCER HEMORRHAGE.
응용 분야
개요Latamoxef was synthesized by Shionogi Pharmaceuticals in 1975 starting with benzylpenicillin and using a novel drug design. The oxacephem nucleus, in which the sulfur atom had been replaced by oxygen, was substituted with a methoxyl group at the 7α position, as in the cephamycins. A carboxyl moiety and a hydroxybenzyl group were added at the 7β position, as in carbenicillin, and a methyltetrazolylthiomethyl group was attached at the 3 position. These substitutions resulted in a strong activity against gram-negative bacteria and a high resistance to the action of βlactamase, along with excellent activity against Pseudomonas aeruginosa, even though the compound has no activity against Staphylococcus aureus.
용도Moxalactam Sodium is an oxacephem antibiotic. Moxalactam Sodium is more effective against Escherichia coli and Pseudomonas aeruginosa than cephalosporins.
상·하류 제품 정보
상류 원료
공급사100 곳
台州开创生物医药有限公司+86-0576-88827176 +86-18906581668 · [email protected]
Shandong chuangyingchemical Co., Ltd.
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