Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Naftifine
Naftin · naftifin · Exoderil · NAFTIFINE · AW-105-843 · SN-105-843 · Naftifungin · Naftifine D3
식별자 및 물리적 특성
| CAS No. | 65472-88-0 |
|---|---|
| 분자식 | C21H21N |
| 평균 분자량 | 287.4 g/mol |
| 단동위원소 질량 | 287.16739967 g/mol |
| SMILES | CN(C/C=C/c1ccccc1)Cc1cccc2ccccc12 |
| InChIKey | OZGNYLLQHRPOBR-DHZHZOJOSA-N |
| PubChem CID | 47641 |
| ChEMBL | CHEMBL626 |
| ChEBI | CHEBI:7451 |
| DTXSID | DTXSID6048545 |
화학 및 물리적 성질
| XLogP | 5.1 |
|---|---|
| 극성 표면적 | 3.2 |
| 수소 결합 공여자 수 | 0 |
| 수소 결합 수용자 수 | 1 |
| 회전 가능 결합 수 | 5 |
| 무거운 원자 수 | 22 |
| 형식 전하 | 0 |
| 복잡도 | 342 |
| 의약품 | Pharmaceuticals -> Listed in ZINC15Pharmaceuticals -> Antibiotics |
| Human Drugs | Breast FeedingLactationMilk, HumanAnti-Infective AgentsAntifungal Agents |
| 녹는점 | 177 °C |
| 끓는 점 | bp0.015 torr 162-167° |
| 밀도 | 1.082±0.06 g/cm3(Predicted) |
| 용해도 | Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Very Slightly) |
| 물리적 상태 | 두꺼운 기름 |
| pKa(산도 계수) | 7.99±0.50(Predicted) |
| 색상 | 무색~진한 노란색 |
| Merck | 6355 |
안전 및 규제
| Effects During Pregnancy and Lactation | ◉ Summary of Use during Lactation |
|---|---|
| 관세 코드 | 29214990 |
용도
용도
Naftifine (Naftin) is a synthetic allylamine derivative topical antifungal agent that works by blocking squalene 2,3-epoxidase, resulting in increased cell membrane permeability and cell death. It is structurally and pharmacologically related to terbinafine. It also has some antiinflammatory properties that may be due to its ability to alter chemotaxis by polymorphonucleocytes. It is most effective against dermatophytes, moderately active against molds, and less active against yeasts, including C. albicans.