페닐비소 산화물

Phenylarsine Oxide

HCID 4778CAS 637-03-6

기본 정보

표준 SMILES
O=[As]c1ccccc1
InChIKey
BQVCCPGCDUSGOE-UHFFFAOYSA-N
분자식
C6H5AsO
평균 분자량
168.02 g/mol
단동위원소 질량
167.95563628

개요

Phenylarsine oxide is an arsine oxide derived from phenylarsine. It has a role as an EC 3.1.3.48 (protein-tyrosine-phosphatase) inhibitor, an antineoplastic agent and an apoptosis inducer.

이름 및 식별자

우선 이름
Phenylarsine Oxide
IUPAC
arsorosobenzene
현지명
페닐비소 산화물
영어명
Phenylarsine oxide
분자식
C6H5AsO
분자량
168.02

이름 및 동의어

phenylarsine oxide637-03-6OxophenylarsinearsorosobenzeneArzenePhenylarsenoxideArsenosobenzeneARSINE, OXOPHENYL-Phenyl arsine oxideFenylarsinoxidPhAsODTXSID5042249
이름 더 보기
페닐비소산화물페닐비소산화물(PHENYLARSINEOXIDE)페닐아르신옥사이드PolyalphaolefinsPAOPoly α-olefinsarsenoso-benzenoxophenyl-arsin
0HUR2WY345NSC-42470DTXCID3022249CHEBI:75253RefChem:861713211-275-32-(Hydroxypropyl)phenylarsinic acidBenzene, arsenoso-

데이터베이스 식별자

CAS
637-03-6
PubChem CID
4778
DTXSID
DTXSID5042249
ChEMBL
CHEMBL477683
ChEBI
CHEBI:75253
UNII
0HUR2WY345
EC Number
211-275-3
Nikkaji
J6.913B

물성

구조 계산 물성

극성 표면적
17.1 Ų
수소 결합 공여자 수
0
수소 결합 수용자 수
1
회전 가능 결합 수
0
무거운 원자 수
8

실험 및 물리화학적 성질

Chemical ClassesMetals -> Arsenic Compounds, Organic
Physical DescriptionCrystals with a melting point of 144-146 degrees C; [Merck Index]

물리화학적 성질

녹는점
145 · 145-148 °C
저장 조건
Poison room
용해도
50 mg/mL · DMSO: 50mg/mL
물리적 상태
가루
색상
흰색에서 노란색으로
생물학적 소스
synthetic (organic)

화학적 성질

WHITE TO ALMOST WHITE CRYSTALS OR CRYST. POWDER

안전 및 규제

GHS 분류

GHS Classification · 4건

Danger

H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]

P261, P264, P270, P271, P273, P301+P316, P304+P340, P316, P321, P330, P391, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 48 reports by companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

유해성 정보

Regulatory Information · 2건

Chemical: Arsine, oxophenyl-

Restricted substance: Phenylarsine oxide

Hazards Summary · 1건

Acute or chronic arsenic poisoning may result from ingestion or inhalation of a sufficient dose; [MSDSonline] Not found in any pesticide products; [NPIRS] Almost nothing is known regarding health effects of organic arsenic compounds in humans. Studies in animals show that some simple organic arsenic compounds are less toxic than inorganic forms. Ingestion of methyl and dimethyl compounds can cause diarrhea and damage to the kidneys. [ATSDR ToxProfiles]

Hazard Classes and CategoriesAcute Tox. 3 (100%)

안전 및 보호

Exposure Control and Personal Protection · 1건

TIH (Toxic Inhalation Hazard) - Term used to describe gases and volatile liquids that are toxic when inhaled. Some are TIH materials themselves, e.g., chlorine, and some release TIH gases when spilled in water, e.g., chlorosilanes. [ERG 2016].

Permissible Exposure Limit (PEL)0.5 [mg/m3], as As

안전 데이터

wgk
3
tsca
TSCA listed
rtecs
CH8100000
ridadr
UN 3465 6.1/PG 3
독성
LD50 ipr-mus: 1930 mg/kg JPETAB 74,210,42
HS 번호
29310099

화학 및 산업

약리 정보

MeSH Pharmacological Classification · 2건

Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.

Drugs or agents which antagonize or impair any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system.

용도 및 제조

UsesInhibits protein-tyrosine-phosphatase. [ChemIDplus] Used in veterinarian medicine as a poultry coccidiostat; [6949, Merck Index]
General Manufacturing InformationArsine, oxophenyl-: ACTIVE

응용 분야

용도Phenylarsine oxide is used as a poultry coccidiostat in veterinary medicine. It is also used in a membrane-permeable protein tyrosine phosphatase inhibitor.

일반 설명Phenylarsine oxide (PhAsO4) is a bifunctional SH group chemical. It is hydrophobic in nature.

상·하류 제품 정보

공급사50 곳

梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
上海麦克林生化科技股份有限公司021-50706066 15221275939 · [email protected]
上海仲因实业有限公司2537653158 16621191650 · [email protected]
Dayang Chem (Hangzhou) Co.,Ltd.+86-0571-88938639 17705817739 · [email protected]

추가 설명

정의ChEBI: An arsine oxide derived from phenylarsine.

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