PJ-34

PJ34 is a member of the class of phenanthridines that is 5,6-dihydrophenanthridine substituted at positions 2 and 6 by (N,N-dimethylglycyl)amino and oxo groups, respectively. It is a potent inhibitor of poly(ADP-ribose) polymerases PARP1 and PARP2 (IC50 of 110 nM and 86 nM, respectively) and exhibits anti-cancer, cardioprotective and neuroprotective properties. It has a role as an antiatherosclerotic agent, an antineoplastic agent, an angiogenesis inhibitor, an EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor, a neuroprotective agent, an anti-inflammatory agent, an apoptosis inducer and a cardioprotective agent. It is a secondary carboxamide, a tertiary amino compound and a member of phenanthridines. It is a conjugate base of a PJ34(1+).