Prilocaine
PRILOCAINE BASE · Aβ25-35 · l67 · Prilocain · Citanest · Propitocaine · Prilocaine Free Base · 2-(PropylaMino)-N-(o-tolyl)propanaMide
식별자 및 물리적 특성
| CAS No. | 721-50-6 |
|---|---|
| 분자식 | C13H20N2O |
| 평균 분자량 | 220.31 g/mol |
| 단동위원소 질량 | 220.15756326 g/mol |
| SMILES | CCCNC(C)C(=O)Nc1ccccc1C |
| InChIKey | MVFGUOIZUNYYSO-UHFFFAOYSA-N |
| PubChem CID | 4906 |
| ChEMBL | CHEMBL1194 |
| ChEBI | CHEBI:8404 |
| EC No. | 211-957-0 |
| DTXSID | DTXSID7031955 |
화학 및 물리적 성질
| XLogP | 2.1 |
|---|---|
| 극성 표면적 | 41.1 |
| 수소 결합 공여자 수 | 2 |
| 수소 결합 수용자 수 | 2 |
| 회전 가능 결합 수 | 5 |
| 무거운 원자 수 | 16 |
| 형식 전하 | 0 |
| 복잡도 | 218 |
| 의약품 | Pharmaceuticals |
| LogP(분배 계수) | log Kow= 2.11 |
| 냄새 | ODORLESS |
| 맛 | INITIALLY ACID & THEN BITTER TASTE |
| Color/Form | NeedlesWHITE |
| 용해도 | Crystals from ethanol + isopropyl etherreadily sol in watermp 167-168 °C /Hydrochloride/FREELY SOL IN ALCSLIGHTLY SOL IN CHLOROFORMVERY SLIGHTLY SOL IN ACETONEPRACTICALLY INSOL IN ETHER3.26e-01 g/L물에는 약간 용해되고, 아세톤과 에탄올에는 매우 용해됩니다(96%). |
| Human Drugs | Breast FeedingLactationAnesthetics, LocalFDA approved drugs -> Active ingredientPharmaceuticals |
| 끓는 점 | 159-162 °C at 1.00E-01 mm Hg159-162 °C @ 1 mm Hgbp0.1 159-162° |
| 녹는점 | 37-38 °C37 - 38 °C37-38° |
| 굴절률 | Index of refraction: 1.5298 @ 20 °C/DnD20 1.5298 |
| Physical Description | Solid |
| Stability/Shelf Life | STABLE IN LIGHT & AIR |
| 밀도 | 1.0117 (rough estimate) |
| 저장 조건 | 2-8°C |
| pKa(산도 계수) | pKa 7.32 or 7.89 (Uncertain) |
| 물리적 상태 | Solid |
| 색상 | White to off-white |
| 용해도 | 6.169g/L(25℃) |
| 주요 응용 | 의약품(소분자) |
| InChI | InChI=1S/C13H20N2O/c1-4-9-14-11(3)13(16)15-12-8-6-5-7-10(12)2/h5-8,11,14H,4,9H2,1-3H3,(H,15,16) |
| InChIKey | MVFGUOIZUNYYSO-UHFFFAOYSA-N |
| SMILES | C(NC1=CC=CC=C1C)(=O)C(NCCC)C |
| NIST | Propanamide, n-(2-methylphenyl)-2-(propylamino)-(721-50-6) |
화학적 성질
White or almost white, crystalline powder.
안전 및 규제
| GHS 분류 | WarningH302 (98.6%): Harmful if swallowed [Warning Acute toxicity, oral]P264, P264+P265, P270, P273, P280, P301+P317, P302+P352, P305+P351+P338, P321, P330, P332+P317, P337+P317, P362+P364, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 69 reports by companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. |
|---|---|
| 규제 정보 | Propanamide, N-(2-methylphenyl)-2-(propylamino)-: Does not have an individual approval but may be used under an appropriate group standard |
| 기타 안전 정보 | IMAP assessments - Propanamide, N-(2-methylphenyl)-2-(propylamino)-: Environment tier I assessment |
| FDA 요건 | Manufacturers, packers, and distributors of drug and drug products for human use are responsible for complying with the labeling, certification, and usage requirements as prescribed by the Federal Food, Drug, and Cosmetic Act, as amended (secs 201-902, 52 Stat. 1040 et seq., as amended21 U.S.C. 321-392). |
| Hazard Classes and Categories | Acute Tox. 4 (98.6%) |
| 처리 방법 | SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices. |
| 상호 작용 | ...MOUSE TRIALS INDICATE INCR TOXICITY WHEN COMBINED WITH TETRACAINE....PRILOCAINE...REPORTED TO INTERACT WITH SUCCINYLCHOLINE /RESULTING IN INCR IN INTENSITY & DURATION OF SUCCINYLCHOLINE-INDUCED NEUROMUSCULAR BLOCKADE & RESP DEPRESSIONOTHER DEPOLARIZING MUSCLE RELAXANTS (EG DECAMETHONIUM) & NONDEPOLARIZING MUSCLE RELAXANTS (EG GALLAMINE TRIETHIODIDE & PANCURONIUM) MAY BEHAVE SIMILARLY/..../PRILOCAINE/ PRODUCED A SLIGHT INCR IN INTENSITY OF NEUROMUSCULAR BLOCKADE /OF ALCURONIUM CHLORIDE/. ...MARKED DECR IN TIDAL VOL, INDICATING RESP DEPRESSION, WAS OBSERVED...EPINEPHRINE PROLONGS THE EFFECT /OF PRILOCAINE/. /PRILOCAINE HCL/For more Interactions (Complete) data for PRILOCAINE (15 total), please visit the HSDB record page. |
| Non-Human Toxicity Excerpts | ...CAPABLE OF INDUCING METHEMOGLOBINEMIA IN LAB ANIMALS... /PRILOCAINE HCL/ |
| Antidote and Emergency Treatment | ALTHOUGH METHEMOGLOBINEMIA IS READILY REVERSED BY THE IV ADMIN OF METHYLENE BLUE ... THE THERAPEUTIC EFFECT MAY BE SHORT-LIVED BECAUSE METHYLENE BLUE MAY BE CLEARED BEFORE CONVERSION OF ALL THE METHEMOGLOBIN TO HEMOGLOBIN. /PRILOCAINE HCL/ |
| Effects During Pregnancy and Lactation | ◉ Summary of Use during Lactation◈ What is prilocaine? |
| 수질 위해 등급(WGK) | WGK 3 |
| 관세 코드 | 2924296000 |
| 위험 등급 | Acute Tox. 4 OralEye Irrit. 2 |
| 저장 분류 | 11 - Combustible Solids |
| 유해 물질 데이터 | 721-50-6(Hazardous Substances Data) |
용도
용도
Prilocaine is a local anesthetic of the amino amide type. Prilocaine is often used in dentistry. Prilocaine is also often combined with lidocaine as a preparation for dermal anesthesia (lidocaine/prilocaine or EMLA), for treatment of conditions like paresthesia.
일반 설명
Prilocaine hydrochloride is a water-soluble salt available asa solution for nerve block or infiltration in dental procedures.Prilocaine is used for intravenous regional anesthesiaas the risk of CNS toxicity is low because of the quick metabolism.Prilocaine prepared in the crystal form is used inEMLA for topical administration to decrease painful needlesticks in children. Prilocaine 4% solution should be protectedfrom light and the manufacturer recommends discardingif the solution turns pinkish or slightly darker than lightyellow. Solutions are available in various concentrations upto 4%, with or without epinephrine and with or withoutpreservatives.