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HCID 4937생성일: 2026년 10월 26일

프로파진

프로파진 · PROPAZINE · maxx90 · G-30028 · Gesamil · PROZINEX · MILO-PRO · Milogard

https://huagongshe.com/ko/chemical/4937

프로파진 분자 구조식

식별자 및 물리적 특성

CAS No.139-40-2
분자식C9H16N5Cl
평균 분자량229.71 g/mol
단동위원소 질량229.10942319 g/mol
SMILESCC(C)Nc1nc(Cl)nc(NC(C)C)n1
InChIKeyWJNRPILHGGKWCK-UHFFFAOYSA-N
PubChem CID4937
ChEMBLCHEMBL1333189
ChEBICHEBI:38067
EC No.109-875-4
DTXSIDDTXSID3021196
현지명프로파진

화학 및 물리적 성질

XLogP2.9
극성 표면적62.7
수소 결합 공여자 수2
수소 결합 수용자 수5
회전 가능 결합 수4
무거운 원자 수15
형식 전하0
복잡도169
pHVery weak base
SpringerMaterials PropertiesBoiling point
농약Pesticide -> EPA IRISHerbicidesActive substance -> EU Pesticides database: Not approvedPesticides -> Herbicides, TriazinePesticides -> Herbicides
LogP(분배 계수)log Kow = 2.933.09
밀도1.162 g/cu cm at 20 °C1.162 g/cm³
Color/FormColorless powderCrystals
용해도6.2 benzene6.2 toluene2.5 carbon tetrachloride5 diethyl ether (all in g/kg at 20 °CDifficult to dissolve in organic solventsIn water, 8.6 mg/L at 22 °CSolubility in water at 22 °C: very poorChloroform (Heated), DMSO (Slightly), Methanol (Slightly)
CorrosivityNONCORROSIVE UNDER NORMAL USE CONDITIONS
Endocrine DisruptorsPotential endocrine disrupting compound
DecompositionWhen heated to decomposition it emits toxic fumes of nitroxides and Cl-.
녹는점229.7 °C213 °C212-214°C
증기압0.00000013 [mmHg]1.31X10-7 mm Hg at 25 °Cnegligible0Pa at 25℃
끓는 점368.7°C (rough estimate)
굴절률1.6110 (estimate)
인화점11 °C
저장 조건APPROX 4°C
pKa(산도 계수)2.28±0.10(Predicted)
용해도8.6mg/L(22 ºC)
Merck13,7904
BRN747081
헨리 상수2.1×103 mol/(m3Pa) at 25℃, HSDB (2015)
주요 응용농업청소용품화장품환경음식 및 음료개인 위생 관리
InChI1S/C9H16ClN5/c1-5(2)11-8-13-7(10)14-9(15-8)12-6(3)4/h5-6H,1-4H3,(H2,11,12,13,14,15)
InChIKeyWJNRPILHGGKWCK-UHFFFAOYSA-N
SMILESCC(C)Nc1nc(Cl)nc(NC(C)C)n1
LogP(분배 계수)3.01 at 25℃ and pH7.1
NIST1,3,5-Triazine-2,4-diamine, 6-chloro-N,N'-bis(1-methylethyl)-(139-40-2)
EPAPropazine (139-40-2)

화학적 성질

2,4-Bis(isopropylamino)-6-chloro-1,3,5-triazine is a colorless crystalline solid or powder.

안전 및 규제

GHS 분류WarningH351: Suspected of causing cancer [Warning Carcinogenicity]P203, P273, P280, P318, P391, P405, and P501 (click each P-code to see the statement)H351 (100%): Suspected of causing cancer [Warning Carcinogenicity]
규제 정보Hazard Traits - Developmental ToxicityReproductive Toxicity2002/2076Status: Active Update: 14-09-2010 https://echa.europa.eu/registration-dossier/-/registered-dossier/10793Propazine: Does not have an individual approval but may be used under an appropriate group standard
기타 안전 정보IMAP assessments - 1,3,5-Triazine-2,4-diamine, 6-chloro-N,N'-bis(1-methylethyl)-: Environment tier I assessment
화재 위험Combustible. Gives off irritating or toxic fumes (or gases) in a fire. Heating will cause rise in pressure with risk of bursting.
화재 가능성NONFLAMMABLE.
유해성 요약An eye irritant[ICSC] A mild skin, eye, and upper respiratory tract irritant[HSDB] For the triazine herbicides, systemic toxicity unlikely unless large amounts are ingestedMay cause irritation[EPA Pesticides, p. 121]The major hazards encountered in the use and handling of propazine stem from its toxicologic properties. Toxic by all routes (ie, inhalation, ingestion, and dermal contact), exposure to this colorless powder may occur from its maufacture and use as an herbicide. Effects from exposure may include shortness of breath, muscle spasms, ataxia, and anorexia. In activities and situations where over exposure may occur, wear a self-contained breathing apparatus and personal protective clothing. If contact should occur, immediately flush affected skin or eyes with running water for at least 15 minutes. Remove contaminated clothing and shoes at the site. While propazine does not ignite easily, it may burn with the production of irritating and poisonous gases. For fires involving propazine, extinguish with dry chemical, CO2, Halon, water spray, fog, or standard foam. Propazine may be shipped domestically via air, rail, road, and water, in containers bearing the label "Poison". Small dry spills of propazine may be placed into a clean, dry, covered container for later disposal (liquid solutions are first absorbed in sand or other noncombustible absorbent). Large liquid spills should be diked far ahead to prevent propazine from entering water sources and sewers. Before implementing land disposal of propazine, consult with regulatory agencies for guidance.
EC 분류Symbol: Xn, NR: 40-50/53S: (2)-36/37-60-61
UN 분류UN Hazard Class: 9UN Pack Group: III
Special ReportsUSEPA/Office of Pesticide ProgramsReport of the Food Quality Protection Act (FQPA) Tolerance Reassessment Progress and Risk Management Decision (TRED) for Propazine EPA 738-R-06-009 (April 2006). EPA issues a TRED for a pesticide that requires tolerance reassessment decisions, but does not require a reregistration eligibility decision at present because: the pesticide was initially registered after November 1, 1984, and by law is not included within the scope of the reregistration programEPA completed a RED for the pesticide before FQPA was enacted on August 3, 1996or the pesticide is not registered for use in the U.S. but tolerances are established that allow crops treated with the pesticide to be imported from other countries.[Available from, as of June 14, 2007: http://www.epa.gov/pesticides/reregistration/status.htm]USEPA/Office of Pesticides ProgramsPropazine: Revised HED Risk Assessment for the Tolerance Reassessment Eligibility Decision Document (TRED) which includes a New Use on Grain Sorghum. 55 p. (December 2005). Available at EPA-HQ-OPP-2005-0496-0004 in http://www.Regulations.gov as of June 11, 2007
TSCA 요건Section 8(a) of TSCA requires manufacturers of this chemical substance to report preliminary assessment information concerned with production, exposure, and use to EPA as cited in the preamble in 51 FR 41329.Pursuant to section 8(d) of TSCA, EPA promulgated a model Health and Safety Data Reporting Rule. The section 8(d) model rule requires manufacturers, importers, and processors of listed chemical substances and mixtures to submit to EPA copies and lists of unpublished health and safety studies. Propazine is included on this list.
FIFRA 요건Tolerances are established for negligible residues (N) of the herbicide propazine (2-chloro-4,6-bis(isopropylamino)-s-triazine in or on the following raw agricultural commodities: [Table#3120]The Agency has evaluated all existing tolerances for sorghum (forage, grain, stover, and sweet) and has determined that the available data provide adequate support to conclude that there is a reasonable certainty that no harm to the general population, infants, children, or any other population subgroup, will result from these tolerances. This decision does not include an assessment of dietary exposure from drinking water because propazine is not currently registered for use on sorghum in the United States and the only registered use for propazine in the United States (a non-food use on container-grown ornamentals in greenhouses) will not result in exposure from drinking water. There are also no residential uses registered for propazine so aggregate risk estimates are the same as those for dietary exposure from food. Dietary exposure to propazine from food was determined to be essentially zero, or less than 1% of the aPAD and cPAD, and not of concern to the Agency. Therefore, no mitigation measures are necessary at this time for the pesticide propazine.
Chemical DangersDecomposes on heating and on burning. This produces toxic gases of nitrogen oxides and chlorine.
Hazard Classes and CategoriesCarc. 2 (100%)Carcinogenicity - category 2Serious eye damage/eye irritation - Category 2B
소화Use water spray, foam, powder, carbon dioxide.
응급 조치Fresh air, rest.Remove contaminated clothes. Rinse and then wash skin with water and soap.Rinse with plenty of water (remove contact lenses if easily possible).Rinse mouth.
안전 보관Provision to contain effluent from fire extinguishing. Store in an area without drain or sewer access.
소화 절차This chemical is a combustible liquid. Use dry chemical, carbon dioxide, water spray, or alcohol foam extinguishers. Poisonous gases are produced in fire including nitrogen oxides and chlorine. If material or contaminated runoff enters waterways, notify downstream users of potentially contaminated waters. Notify local health and fire officials and pollution control agencies. From a secure, explosion-proof location, use water spray to cool exposed containers. If cooling streams are ineffective (venting sound increases in volume and pitch, tank discolors, or shows any signs of deforming), withdraw immediately to a secure position. If employees are expected to fight fires, they must be trained and equipped in OSHA 1910.156.If material on fire or involved in fire: Extinguish fire using agent suitable for type of surrounding fire. (Material itslef does not burn or burns with difficulty.) Use water in flooding quantities as fog. Use "alcohol foam", dry chemical or carbon dioxide. /Triazine pesticide, solid NOS/
보관 조건Do not contaminate water, food or feed by storage or disposal. ... Store product in original container only, away from other pesticides, fertilizer, food for feed. /Propazine 4L/Store in cool, dry, well-ventilated area out of reach of children and animals.
정리 방법Evacuate persons not wearing protective equipment from area of spill or leak until clean-up is complete. Remove all ignition sources. Collect powdered material in the most convenient and safe manner and deposit in sealed containers. Ventilate area after clean-up is complete. It may be necessary to contain and dispose of this chemical as a hazardous waste. If material or contaminated runoff enters waterways, notify downstream users of potentially contaminated waters. Contact your Department of Environmental Protection or your regional office of the federal EPA for specific recommendations. If employees are required to clean-up spills, they must be properly trained and equipped. OSHA 1910.120(q) may be applicable.
처리 방법SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air qualitypotential migration in soil or watereffects on animal, aquatic, and plant lifeand conformance with environmental and public health regulations.PESTICIDE DISPOSAL: Wastes resulting from the use of this product may be dfsposed of on site or at an approved waste disposal facility. CONTAINER DISPOSAL: Triple rinse (or equivalent). Then offer for recycling or reconditioning or puncture and dispose of in a sanitary landfill or incinerate if allowed by state and local authorities, by burning. If burned, stay out of smoke. /Propazine 4L/This pesticide is toxic to aquatic invertebrates. Do not apply directly to water, to areas where surface water is present, or to intertidal areas below the mean high water mark. Do not apply when weather conditions favor drift from treated areas. Runoff and drift from treated areas may be hazardous to aquatic organisms in neighboring areas. Do not contaminate water when disposing of equipment washwaters. /Propazine 4L/Noncombustible containers should be crushed & buried under more than 40 cm of soil. /Herbicides/
누출 처리Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.
Preventive MeasuresUSER SAFETY RECOMMENDATIONS. Users should: 1. Wash hands before eating, drinking, chewing gum, using tobacco or using the toilet. 2. Remove clothing immediately if pesticide gets inside. Then wash thoroughly and put on clean clothing, 3. Users should remove PPE immediately after handling this product. Wash the outside of gloves before removing. As soon as possible, wash thoroughly and change into clean clothing. /Propazine 4L/Follow manufacturer's instructions for cleaning/maintaining PPE. If no such instructions for washables, use detergent and hot water. Keep and wash PPE separately from other laundry. /Propazine 4L/FIRST AID. IF SWALLOWED: Call a poison control center or doctor immediately for treatment advice. Have person sip a glass of water if able to swallow. Do not induce vomiting unless told to do so by a poison control center or doctor. Do not give anything by mouth to an unconscious person. IF INHALED: Move person to fresh air. If person is not breathing, call 911 or an ambulance, then give artificial respiration ... . Call a poison control center or doctor for further treatment advice. IF ON SKIN OR CLOTHING: Take off contaminated clothing. Rinse skin immediately with plenty of water for 15-20 minutes. Call a poison control center or doctor for treatment advice. IF IN EYES: Hold eye open and rinse slowly and gently with water for 15-20 minutes. Remove contact lenses, if present, after the first 5 minutes, then continue rinsing eye. Call a poison control center or doctor for treatment advice. Have the product container or label with you when calling a poison control center or doctor, or going for treatment... /Propazine 4L/Propazine can travel (seep or leach) through soil and can enter ground water which may be used as drinking water. ... This product must not be mixed or loaded within 50 ft. of intermittent streams and rivers, natural or impounded lakes and reservoirs. This product must not be applied aerially or by ground within 66 ft. of the points where surface water runoff enters perennial or Intermittent streams and rivers or within 200 ft. around natural or impounded lakes and reservoirs. If this product is applied to highly erodible land, the 66 ft. buffer or setback from runoff entry points must be planted to crop, seeded with grass or other suitable crop. This product must not be mixed/loaded, or used within 50 ft. of all wells including abandoned wells, drainage wells, and sink holes. Operations that involve mixing, loading, rinsing, or washing of this product into or from pesticide handling or application equipment or containers within 50 ft. /Propazine 4L/For more Preventive Measures (Complete) data for PROPAZINE (10 total), please visit the HSDB record page.
Eye PreventionWear safety spectacles.
Fire PreventionNO open flames.
Inhalation RiskA nuisance-causing concentration of airborne particles can be reached quickly when dispersed.
생태독성 수치LC50 Salmo gairdneri (rainbow trout) 18 mg/L for 96 hr /TechnicalConditions of bioassay not specified/LC50 Lepomis macrochirus (bluegill sunfish) > 100 mg/L for 96 hr /TechnicalLC50 /Carassius auratus/ (Goldfish) >32.0 mg/L for 96 hr /Conditions of bioassay not specified/LC50 /Colinus virginianus/ (Bobwhite quail) oral >10000 ppm (8 day diet) /Technical/For more Ecotoxicity Values (Complete) data for PROPAZINE (12 total), please visit the HSDB record page.
환경 거동TERRESTRIAL FATE: Depending upon the region of the USA, soil treated with propazine may be planted to sorghum, corn, or cotton 12 months following application. Propazine will persist longer under dry & cold conditions or other conditions not conducive to chemical & biological degradation.TERRESTRIAL FATE: THE LONG SOIL PERSISTENCE OF THESE CMPD DOES ... CREATE THE PROBLEM OF SOIL CARRY OVER, WHICH CAN DAMAGE SUCCEEDING CASH CROPS. THEREFORE EXTREME CAUTION MUST BE TAKEN IN THEIR APPLICATION ON CROPLAND TO AVOID SUCH INJURY TO FOLLOWING CROPS. /TRIAZINES/TERRESTRIAL FATE: Based on a classification scheme(1), Koc values of 84-500 measured in 4 European soils(2), indicate that propazine is expected to have moderate mobility in soil(SRC). Volatilization of propazine from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 4.6X10-9 atm-cu m/mole(SRC) based upon its vapor pressure, 1.31X10-7 mm Hg(3), and water solubility, 8.6 mg/L(4). Propazine is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(3). The half-lives for degradation (purportedly mainly soil-catalyzed hydrolysis) of propazine in Hatzenbuhl soil at pH 4.8 and Neuhofen soil at pH 6.5 are 62 and 127 days, respectively(5). Propazine was 36-64% degraded in a series of aerobic soil beds over a 54 week incubation period and 5.7-75% degraded in a series of anaerobic/aerobic cycled soil beds over a 54 week incubation period(6). The greatest amount of biodegradation occurred in beds that were treated with lime and organic matter(6).TERRESTRIAL FATE: The field half-life of propazine is reported as 135 days(1). A decrease of the amount of inhibition of Italian ryegrass to below 20% inhibition of growth occurred within 4.5 to 25 weeks and in >60 weeks at application rates of 0.25 and 1-4 pounds/acre, respectively(2). Soil treated with propazine is suitable for the planting of sorghum, corn or cotton as soon as 12 months after application, depending upon the region of the US(3). The persistence of propazine in soil has been reported to be at least 2-3 years based upon reduced soybean yields observed after treatment at 4 pound/acre(4).For more Environmental Fate (Complete) data for PROPAZINE (6 total), please visit the HSDB record page.
노출 경로The substance can be absorbed into the body by ingestion.
Milk Concentrations...In a goat metabolism study where [14C]propazine was administered orally to a lactating goat at 9.9 ppm (-20x the estimated dietary burden of 0.5 ppm) in the diet for seven consecutive days, total radioactive residues (TRR) were 0.080- 0.238 ppm in milk... . The parent propazine was not detected in goat milk... . The chlorometabolite G-28273 (DACT) was the principal residue identified in milk (63.4% TRR, 0.141 ppm)... . The metabolite G-30033 was identified in milk (9.4% TRR, 0.021 ppm) but not in tissues. The remaining radioactivity in goat milk and tissues was characterized to be comprised of up to six unknown metabolites. ...Each unknown accounted for <7% TRR in milk... .Another goat metabolism study was performed using a radiolabeled hydroxymetabolite of propazine as the test substance. TRR were 0.025-0.029 ppm in milk ...The test substance, 2-hydroxypropazine, was the major residue identified in all matrices accounting for ...65.0-69.4% TRR (0.017-0.020 ppm) in milk. The only other metabolite identified was desisopropyl hydroxypropazine, which was detected in minor amounts ...8.2-8.5% TRR (0.002 ppm) in milk.
독성 요약Propazine is a systemic herbicide that is usually applied to the soil, absorbed through leaves and roots, and acts by inhibiting photosynthesis within the targeted plant. It is used as a selective herbicide to control most annual grasses and broadleaf weeds before the weeds emerge or after removal of weed growth. Propazine is formulated as a flowable concentrate, is registered for use on container-grown ornamentals in greenhouses, and is to be applied through flood or drench nozzles only. ... Propazine has a low order of acute toxicity via the oral (Category IV), dermal (Category IV), and inhalation (Category III) routes of exposure. It is not an eye or skin irritant, or a dermal sensitizer. In a sub-chronic developmental study, incomplete or absent bone formation or ossification was observed in fetal rats following exposure of pregnant rats to propazine. These developmental effects are presumed to occur after a single exposure and are therefore appropriate for consideration in the acute exposure scenario for dietary risk from food. These adverse effects were the basis for identification of a developmental endpoint for acute dietary exposure to propazine in females ages 13 to 49. The corresponding highest dose or level of exposure at which these adverse effects were not observable in female rats ("no observed adverse effects level" or NOAEL) was 10 mg/kg/day. After subchronic and chronic exposure to propazine, a variety of species were shown to exhibit neuroendocrine effects resulting in both reproductive and developmental consequences that are considered relevant to humans. These neuroendocrine effects are biomarkers of a neuroendocrine mechanism of toxicity that is shared by several other structurally-related chlorinated triazines including atrazine, simazine, and three chlorinated degradates - G-28279 (des-isopropyl atrazine or DIA), and G-30033 (des-ethyl atrazine or DEA), and G-28273 (diaminochlorotriazine or DACT) - the latter two which can result from the degradation of propazine. These six compounds disrupt the hypothalamic-pituitary-gonadal (HPG) axis, part of the central nervous system, causing cascading changes to hormone levels and developmental delays. For propazine, a neuroendocrine endpoint was identified for chronic dietary exposure based on adverse effects of estrous cycle alterations and luteinizing hormone (LH) surge suppression observed in a LH surge study on female rats exposed to atrazine. The corresponding NOAEL was 1.8 mg/kg/day. ... Propazine's two chlorinated degradates, DEA and DACT, are considered to have toxicity equal to the parent compound in respect to their common neuroendocrine mechanism of toxicity. Another degradate, hydroxy-propazine, was identified, which is expected to have a different toxicological profile from propazine based on the toxicological data available for an analogous metabolite for atrazine, hydroxy-atrazine. ...
생태독성 발췌//BIRDS and MAMMALS/ TOXICOLOGICAL INVESTIGATIONS CONDUCTED WITH BOBWHITE QUAIL, MALLARD DUCKS ... HAVE SHOWN PROPAZINE TO HAVE A VERY LOW TOXICITY TO THESE SPECIES./AQUATIC SPECIES/ TOXICOLOGICAL INVESTIGATIONS CONDUCTED WITH ... GOLDFISH, RAINBOW TROUT & BLUEGILL SUNFISH HAVE SHOWN PROPAZINE TO HAVE A VERY LOW TOXICITY TO THESE SPECIES.
Signs and SymptomsCough.Redness. Pain.
Effluent ConcentrationsPropazine was detected at a concn of 100 ppb in a sample of industrial effluent and at 1-7 ppb in the water of the river into which the effluent was discharged(1). It also was detected at 300, 3,000, and 2 ppm in the sediment of the river near the plant, 1.5 km downstream from the plant, and near a nearby dam, respectively(1).
ICSC Environmental DataThe substance is toxic to aquatic organisms. This substance does enter the environment under normal use. Great care, however, should be taken to avoid any additional release, for example through inappropriate disposal.
EPA IRIS InformationPropazine2 x 10 ^-2 mg/kg-day
Medical SurveillancePreliminary medical exam to detect chronic diseases of CNS, liver, heart, kidneys, lung & skin, as well as endocrinological or immunological disturbances, should ... /protect/ susceptible individuals. ... Periodical medical exam of internal organs, skin & eyes is important to avoid chronic occupational intoxications. It should include lab tests & patch tests if necessary. /Herbicides/
Soil Adsorption/MobilityAn avg Koc of 154 was calculated for propazine from 33 soils(1) and an avg Koc of 160 was calculated from 54 soils(2). The Koc of propazine in 4 European soils was measured in the range of 84-500(3). According to a classification scheme(4), this Koc data suggests that propazine is expected to have moderate mobility in soil.PROPAZINE IS READILY ADSORBED ON SOILS CONTAINING HIGH CLAY & ORGANIC MATTER CONTENT. ADSORPTION IS NOT IRREVERSIBLE & DESORPTION WILL OCCUR READILY, DEPENDING ON TEMP, MOISTURE, PH, ETC. ADSORPTION REACHES A MAX WHEN SOIL PH IS IN VICINITY OF PK VALUE OF PROPAZINE (1.85). PROPAZINE IS ADSORBED TO A LOWER EXTENT THAN MOST OTHER COMMERCIAL TRIAZINE HERBICIDES. LEACHING OF PROPAZINE IS LIMITED BY ITS ADSORPTION TO CERTAIN SOIL CONSTITUENTS & ITS LOW WATER SOLUBILITY.Leaching studies for propazine performed on four soils under worst case conditions (30 cm columns leached with 20 in of water) for propazine indicate propazine's mobility in soil-water systems. In a loamy sand (0.7% OM), and a silt loam (2.4% OM), 82.5%, 18%, 69.5%, and 23.6% leached, respectively.
주 식수 지침(ME) MAINE 14 ug/L(FL) FLORIDA 10 ug/L
연방 식수 지침EPA 10 ug/L
수질 위해 등급(WGK)3
TSCA 등재 상태TSCA listed
RTECS 번호XY5300000
운송 번호(UN)UN 3077
독성LD50 orally in rats: >5000 mg/kg (Bailey, White)
관세 코드29336990
위험 문구(R)40-50/53-39/23/24/25-23/24/25-11
위험 표시XnN,N,Xn,T,F
안전 문구(S)36/37-60-61-45-24-16-7
포장분류III
위험 등급9Aquatic Acute 1Aquatic Chronic 1Carc. 2
저장 분류13 - Non Combustible Solids
유해 물질 데이터139-40-2(Hazardous Substances Data)

용도

용도

2,4-Bis(isopropylamino)-6-chloro-1,3,5-triazine is used to control annual grasses and broad-leaved weeds in milo and sweet sorghum.