하이드라메틸논

Store in a cool, dry, secure place and keep container tightly closed. Use product within 3 months after opening for best results.

Safe Storage of Pesticides. Always store pesticides in their original containers, complete with labels that list ingredients, directions for use, and first aid steps in case of accidental poisoning. Never store pesticides in cabinets with or near food, animal feed, or medical supplies. Do not store pesticides in places where flooding is possible or in places where they might spill or leak into wells, drains, ground water, or surface water. /Residential uses/

Sweep up any spill and place in a closed container for disposal.

If a spill occurs, clean it up promptly. Don't wash it away. Instead, sprinkle the spill with sawdust, vermiculite, or kitty litter. Sweep it into a plastic garbage bag, and dispose of it as directed on the pesticide product label./Residential uses/

After Applying a Pesticide, Indoors or Outdoors. To remove pesticide residues, use a bucket to rinse tools or equipment three times, including any containers or utensils that you used when mixing the pesticide. Then pour the rinsewater into the pesticide sprayer and reuse the solution by applying it according to the pesticide product label directions. After applying any pesticide wash your hands and any other parts of your body that may have come in contact with the pesticide..To prevent tracking pesticides inside, remove or rinse your boots or shoes before entering your home. Wash any clothes that have been exposed to a lot of pesticide separately from your regular wash. /Residential uses/

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.

Safe Disposal of Pesticides. The best way to dispose of small amounts of excess pesticides is to use them - apply them - according to the directions on the label. If you cannot use them, ask your neighbors whether they have a similar pest control problem and can use them. If all of the remaining pesticide cannot be properly used, check with your local solid waste management authority, environmental agency, or health department to find out whether your community has a household hazardous waste collection program or a similar program for getting rid of unwanted, leftover pesticides. These authorities can also inform you of any local requirements for pesticide waste disposal. /Residential uses/

Safe Disposal of Pesticides. An empty pesticide container can be as hazardous as a full one because of residues left inside. Never reuse such a container. When empty, a pesticide container should be rinsed carefully three times and the rinsewater thoroughly drained back onto the sprayer or the container previously used to mix the pesticide. Use the rinsewater as a pesticide, following label directions. Replace the cap or closure securely. Dispose of the container according to label instructions. Do not puncture or burn a pressurized container like an aerosol - it could explode. Do cut or puncture other empty pesticide containers made of metal or plastic to prevent someone from reusing them. Wrap the empty container and put it in the trash after you have rinsed it. /Residential uses/

Users must follow manufacturer's instructions for cleaning/maintaining PPE. If no such instructions for washables exist, use detergent and hot water. Keep and wash PPE separately from other laundry.

User Safety Recommendations: Wash hands before eating, drinking, chewing gum, using tobacco, or using the toilet. Remove clothing/PPE immediately if pesticide gets inside and then wash thoroughly and put on clean clothing. Remove PPE immediately after handling hydramethylnon, wash the outside of gloves before removing, and as soon as possible, wash thoroughly and change into clean clothing.

SRP: Contaminated protective clothing should be segregated in such a manner so that there is no direct personal contact by personnel who handle, dispose, or clean the clothing. Quality assurance to ascertain the completeness of the cleaning procedures should be implemented before the decontaminated protective clothing is returned for reuse by the workers. Contaminated clothing should not be taken home at end of shift, but should remain at employee's place of work for cleaning.

Do not apply this product in a way that will contact workers or other persons, either directly or through drift. Only protected handlers may be in the area during application.

For more Preventive Measures (Complete) data for HYDRAMETHYLNON (11 total), please visit the HSDB record page.

Tolerances are established for residues of the insecticide tetrahydro-5,5-dimethyl-2(1H)-pyrimidinone(3-(4-(trifluoromethyl)phenyl)-1-(2-(4-(trifluoromethyl)phenyl)ethenyl)-2-propenylidene)hydrazone in or on the following raw agricultural commodities: [Table#6164]

Excerpt from ERG Guide 171 [Substances (Low to Moderate Hazard)]:

End Use Products Intended for Occupational Use (WPS and Non-WPS)): Applicators and other handlers must wear: long-sleeve shirt and long pants, water-resistant gloves, and shoes plus socks.

A 12-hour restricted entry interval (REI) is required. The PPE required for early entry is: coveralls, water resistant gloves, and shoes plus socks.

LD50 /Anas platyrhynchos/ (Mallard duck) oral >2,510 mg/kg

LD50 /Colinus virginianus/ (Bobwhite quail) oral 1,828 mg/kg

LC50 Anas platyrhynchos (Mallard duck, age 14 days) diet 4355 ppm for 8 days (95% confidence interval: 2877-6592 ppm)[USEPA, Office of Pesticide Programs; Pesticide Ecotoxicity Database (2000) on Tetrahydro-5,5-dimethyl-2(1H)-pyrimidio[3-[4-Trifluoromethyl)phenyl]-1-[2-

LC50 Colinus virginianus (Northern bobwhite, age 14 days) diet 1136 ppm for 8 days (95% confidence interval: 908-1420 ppm)[USEPA, Office of Pesticide Programs; Pesticide Ecotoxicity Database (2000) on Tetrahydro-5,5-dimethyl-2(1H)-pyrimidio[3-[4-Trifluoromethyl)phenyl]-1-[2-

For more Ecotoxicity Values (Complete) data for HYDRAMETHYLNON (32 total), please visit the HSDB record page.

TERRESTRIAL FATE: Based on a classification scheme(1), Koc values of 3,300 and 8,677(2) indicate that hydramethylnon is expected to have very slight to no mobility in soil(SRC). Volatilization of hydramethylnon from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 2.20X10-6 atm-cu m/mole(SRC), based upon its vapor pressure, 2.03X10-8 mm Hg(3), and water solubility, 6.0X10-3 mg/L(3). Hydramethylnon is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(3). Photolysis on soil is diphasic with a half-life of 4 days for the first phase and about 30 days for the second phase(2). A biodegradation half-life for aerobic soil metabolism of 385 days(2) suggests that biodegradation is not an important environmental fate process in soil(SRC).

TERRESTRIAL FATE: The half-life of hydramethylnon in sandy loam was approximately 7 days, 28 days when incorporated into the soil(1). Using test field plots in Florida and Texas, half-lives of 3 days and 55, respectively, were observed with no detections below the 0-6 inch soil depth. Hydramethylnon is reported as persistent and immobile below soil surfaces(2).

AQUATIC FATE: Based on a classification scheme(1), Koc values of 3,300 and 8,677(2) indicate that hydramethylnon is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon an estimated Henry's Law constant of 2.2X10-6 atm-cu m/mole(SRC), derived from its vapor pressure, 2.03X10-8 mm Hg(4), and water solubility, 6.0X10-3 mg/L(4). The photolysis half-lives in aqueous suspension at 25 °C have been reported as 24-33 days (pH 9), 10-11 days (pH 7.02), and 11-12 days (pH 8.87)(4). According to a classification scheme(5), a BCF of 1,300(2), suggests the potential for bioconcentration in aquatic organisms is very high, provided the compound is not metabolized by the organism(SRC). The half-life for anaerobic aquatic metabolism ranges from 445 to 552 days(2) which suggests that biodegradation is not an important environmental fate process in water(SRC).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), hydramethylnon, which has a vapor pressure of 2.03X10-8 mm Hg at 25 °C(2), will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase hydramethylnon is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 3 hrs(SRC), calculated from its rate constant of 1.35X10-10 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Particulate-phase hydramethylnon may be removed from the air by wet or dry deposition(SRC). Hydramethylnon is rapidly degraded in sunlight by photolysis, with a half-life of approximately 1 hour(2).

EXPERIMENTAL: No residues of hydramethylnon were detectable in the milk of goats after being exposed to 0.2 mg/kg hydramethylnon in the daily diet for 8 days(1). No residues were found in the milk of cows after being exposed to 0.05 mg/kg hydramethylnon for 21 consecutive days(1).

/BIRDS and MAMMALS/ An acute oral toxicity study using the technical grade of the active ingredient (TGAI) was conducted to establish the toxicity of hydramethylnon to birds. In Northern bobwhite quail (Colinus virginianus) administered 92% a.i. the LD50 was 1828 mg/kg, leading EPA to conclude that the substance was slightly toxic to bobwhite quail. In Mallard duck (Anas platyrhynchos) administered 92% a.i. the LD50 was 2510 mg/kg, leading EPA to conclude that the substance was practically nontoxic to Mallard ducks. Two avian subacute toxicity tests were also available. In Northern bobwhite quail (Colinus virginianus) 92% a.i. had an 5-day LC50 of 1136 ppm and in Mallard duck (Anas platyrhynchos) 92% a.i. had a 5-day LC50 of 4355 ppm. EPA judged both studies as showing hydramethylnon to be slightly toxic.

/BIRDS and MAMMALS/ Wild mammal testing is required /by EPA for pesticides/ on a case-by-case basis, depending on the results of lower tier laboratory mammalian studies, intended use pattern and pertinent environmental fate characteristics. In most cases, rat or mouse toxicity values obtained from the Agency's files substitute for wild mammal testing. ... In the Norway Rat (Rattus norvegicus), 95% a.i. administered orally produced an LD50 of 817 mg/kg (m) and 1502 mg/kg (f); combined: 1146 mg/kg; EPA considered this information that hydramethylnon is slightly toxic in an acute oral test. In a 3-generation reproductive study in Norway Rat (Rattus norvegicus), administration of 92% a.i. resulted in male infertility at 100 ppm.

/AQUATIC SPECIES/ Two freshwater fish toxicity studies using the technical grade active ingredient were required by EPA to establish the toxicity of hydramethylnon to fish. Three acute studies of 92% a.i. were available. The 96 hr LC50s indicated that hydramethylnon is highly toxic to Rainbow trout (Oncorhynchus mykiss), moderately toxic to Bluegill sunfish (Lepomis macrochirus), and very highly toxic to Channel catfish (Ictalurus punctatus). In a freshwater aquatic invertebrate toxicity test, a 48-hour LC50/ EC50 of 1.14 ppm indicated that the 92% a.i. was moderately toxic to the waterflea (Daphnia magna).

/OTHER TERRESTRIAL SPECIES/ A honey bee acute contact study using the technical grade active ingredient was required for hydramethylnon because its outdoor use may result in honey bee exposure. The LD50 of 68.0 g/bee using 96.8% a.i. demonstrated that hydramethylnon is practically non-toxic to bees on an acute contact basis.

No residues of hydramethylnon were detectable in tissues of goats after being exposed to 0.2 mg/kg hydramethylnon in the daily diet for 8 days(1). No residues were found in tissues of cows after being exposed to 0.05 mg/kg hydramethylnon for 21 consecutive days(1).

Amdro

Hepatic

3 x 10 ^-4 mg/kg-day

Koc values of hydramethylnon have been reported as ranging from 3,300 to 8,677 using loamy sand, sandy loam, loam and silt loam soils, with reported Kds of 1,039-1,782 mL/g(1). According to a classification scheme(2), these Koc values suggest that hydramethylnon is expected to be slightly mobile to immobile in soil.

Tolerances are established for residues of the insecticide tetrahydro-5,5-dimethyl-2(1H)-pyrimidinone(3-(4-(trifluoromethyl)phenyl)-1-(2-(4-(trifluoromethyl)phenyl)ethenyl)-2-propenylidene)hydrazone in or on the following raw agricultural commodities: [Table#6165]

Section 4(g)(2)(A) of FIFRA calls for the Agency to determine, after submission of relevant data concerning an active ingredient, whether products containing the active ingredient are eligible for reregistration. The Agency has previously identified and required the submission of the generic (i.e. active ingredient specific) data required to support reregistration of products containing hydramethylnon. The Agency has completed its review of these generic data and has determined that the data are sufficient to support reregistration of all products containing hydramethylnon. Appendix B identifies the generic data requirements that the Agency reviewed as part of its determination of reregistration eligibility of hydramethylnon and lists the submitted studies that the Agency found acceptable. The data identified in Appendix B were sufficient to allow the Agency to assess the registered uses of hydramethylnon, and to determine that hydramethylnon can be used without resulting in unreasonable adverse effects to humans and the environment. The Agency therefore finds that all products containing hydramethylnon as the active ingredient are eligible for reregistration.

As the federal pesticide law FIFRA directs, EPA is conducting a comprehensive review of older pesticides to consider their health and environmental effects and make decisions about their future use. Under this pesticide reregistration program, EPA examines health and safety data for pesticide active ingredients initially registered before November 1, 1984, and determines whether they are eligible for reregistration. In addition, all pesticides must meet the new safety standard of the Food Quality Protection Act of 1996. Pesticides for which EPA had not issued Registration Standards prior to the effective date of FIFRA '88 were divided into three lists based upon their potential for human exposure and other factors, with List B containing pesticides of greater concern and List D pesticides of less concern. Tetrahydro-5,5-dimethyl-2(1H)-pyrimidinone is found on List B. Case No: 2585; Pesticide type: insecticide; Case Status: OPP is reviewing data from the pesticide's producers regarding its human health and/or environmental effects, or OPP is determining the pesticide's eligibility for reregistration and developing the RED document.; Active ingredient (AI): tetrahydro-5,5-dimethyl-2(1H)-pyrimidinone; Data Call-in (DCI) Date(s): 4/12/91, 7/12/91, 3/3/95, 10/13/95; AI Status: The producers of the pesticide have made commitments to conduct the studies and pay the fees required for reregistration, and are meeting those commitments in a timely manner.

Used as slow-acting stomach poison insecticide for control of ants and cockroaches; [HSDB]

Farming (Pesticides) [Category: Industry]

For hydramethylnon (USEPA/OPP Pesticide Code: 118401) ACTIVE products with label matches. /SRP: Registered for use in the U.S. but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses./

Insecticide for ants (big headed, fire, harvester)

Slow activating stomach poison insecticide

A slow-acting toxicant used successfully in bait for the fire ant, other ants, and cockroaches

Formulations: Oil bait

AMDRO GRANULAR INSECTICIDE: Active Ingredient 0.88% Hydramethylnon

AMDRO 20 FIREANT INSECTICIDE: Active Ingredient 0.88% Hydramethylnon.

HYDRAMETHYLNON TECHNICAL INSECTICIDE: Active Ingredient 98% Hydramethylnon.

For more Formulations/Preparations (Complete) data for HYDRAMETHYLNON (38 total), please visit the HSDB record page.

All Other Basic Organic Chemical Manufacturing

Registered for the control of ants in grasses and non-crop lands such as lawns, turfs, and non-bearing nursery stocks. Also registered for the control of ants and cockroaches in non-food use areas in domestic dwellings and commercial establishments.