Buserelin Acetate
기본 정보
- CAS
68630-75-1- 표준 SMILES
CC(=O)O.CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](COC(C)(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCC(=O)N1- InChIKey
PYMDEDHDQYLBRT-DRIHCAFSSA-N- 분자식
- C62H90N16O15
- 평균 분자량
- 1,299.5 g/mol
- 단동위원소 질량
- 1,298.67715623
개요
Buserelin acetate is an organic molecular entity.
이름 및 식별자
- 우선 이름
- Buserelin Acetate
- IUPAC
- acetic acid;(2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-[(2S)-2-(ethylcarbamoyl)pyrrolidin-1-yl]-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-[(2-methylpropan-2-yl)oxy]-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide
- 영어명
- Buserelin Acetate
- 분자식
- C60H86N16O13.C2H4O2
- 분자량
- 1299.48
이름 및 동의어
Buserelin acetate68630-75-1SuprecurReceptalBuserelin monoacetateConceptalHOE 766MPHOE-766NSC-72517613U86G7YSPDTXSID30218712Suprefact Depot
이름 더 보기
FusetEstoMalItorelinhoe766mpSupreMonBuserecurSuprafactSuprecur-MP
Profact DepotSuprefact FlakonBSRL AcetateAcetate, BuserelinRefChem:54578HOE766DTXCID80141203D-Ser (Bu(t))(6) Pro(9) NEt LHRH Acetate
데이터베이스 식별자
- CAS
68630-75-1- PubChem CID
- 50224
- DTXSID
DTXSID30218712- ChEMBL
CHEMBL2106198- ChEBI
물성
구조 계산 물성
- 극성 표면적
- 478 Ų
- 수소 결합 공여자 수
- 16
- 수소 결합 수용자 수
- 17
- 회전 가능 결합 수
- 33
- 무거운 원자 수
- 93
- 형식 전하
- 0
- 복잡도
- 2,480
실험 및 물리화학적 성질
Animal DrugsPharmaceuticals -> UK Veterinary Medicines Directorate List
물리화학적 성질
- 녹는점
- 186 · 186-188°C
- 저장 조건
- -20 °C · -20°C
- 용해도
- DMSO(약간 용해됨), 메탄올(약간 용해됨), 물(약간 용해됨)
- 물리적 상태
- 고체
- 색상
- 흰색에서 황백색까지
- 안정성
- 흡습성
- InChIKey
- PYMDEDHDQYLBRT-DRIHCAFSSA-N
화학적 성질
White Solid
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
유해성 정보
Regulatory InformationBuserelin acetate: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.
안전 데이터
- wgk
- 3
- rtecs
- OK6370000
- risk_code
- 60
- hazard_code
- T
- safety_code
- 53-22-36/37/39-45
- Hazard Classifications
- Acute Tox. 4 OralRepr. 1B
- 스토리지 클래스
- 6.1C - Combustible acute toxic Cat.3toxic compounds or compounds which causing chronic effects
화학 및 산업
약리 정보
MeSH Pharmacological ClassificationCompounds which increase the capacity to conceive in females.
응용 분야
개요Buserelin acetate is a potent analog of the hypothalamic hormone, luteinizing hormone-releasing hormone (LH-RH). Chronic administration of higher doses of buserelin desensitizes the pituitary, resulting in a decreased production of luteinizing hormone (LH), follicle stimulating hormone (FSH), and eventually sex steroids (testosterone in males and estradiol in females). Initial approval is for use in achieving medical castration in the treatment of advanced prostate cancer. It has also been investigated for the treatment of endometriosis, leiomyoma, precocious puberty, advanced breast cancer and infertility.
용도Gondadotropin-releasing hormone agonist, used to treat hormone-responsive cancers such as prostate and breast cancer. Synthetic nonapeptide agonist analog of LH-RH. Antineolpastic (hormonal).
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