기본 정보
- CAS
25546-65-0- 표준 SMILES
NCC1OC(OC2C(N)CC(N)C(O)C2OC2OC(CO)C(O)C2O)C(N)C(O)C1O- InChIKey
NSKGQURZWSPSBC-UHFFFAOYSA-N- 분자식
- C17H34N4O10
- 평균 분자량
- 454.5 g/mol
- 단동위원소 질량
- 454.22749329
개요
ribostamycin has been reported in Streptomyces fradiae with data available.
이름 및 식별자
- 우선 이름
- 4,6-Diamino-3-hydroxy-2-(pentofuranosyloxy)cyclohexyl 2,6-diamino-2,6-dideoxyhexopyranoside
- IUPAC
- 5-amino-2-(aminomethyl)-6-[4,6-diamino-2-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-3-hydroxycyclohexyl]oxyoxane-3,4-diol
- 영어명
- RIBOSTAMYCIN SULFATE SALT
- 분자식
- C17H34N4O10
- 분자량
- 454.47
이름 및 동의어
RefChem:10694844,6-diamino-3-hydroxy-2-(pentofuranosyloxy)cyclohexyl 2,6-diamino-2,6-dideoxyhexopyranosideDTXCID50197050DTXSID80860346NSC236658RibastaminBu 1709CHEMBL300914SCHEMBL4318426CCG-102472NSC-236658Q3934263
이름 더 보기
ribostamycinsf733ribomycinNSC 138925vistamycindekamycinivhetangmycinantibioticsf733RIBOSTAMYCIN SULPHATERIBOSTAMYCIN DISULFATE
BRD-A86073102-001-01-6D-Streptamine,6-diamino-2,6-dideoxy-.alpha.-D-glucopyranosyl-(1.fwdarw.4)-O-[.beta.-D-ribofuranosyl-(1.fwdarw.5)]-2-deoxy-O-2,6-dideoxy-.alpha.-D-glucopyranosyl-(1.fwdarw.4)-O-[.beta.-D-ribofuranosyl-(1.fwdarw.5)]-2-deoxystreptamine
데이터베이스 식별자
- CAS
25546-65-0、50474-67-4- PubChem CID
- 5066
물성
구조 계산 물성
- XLogP
- -6.3
- 극성 표면적
- 262 Ų
- 수소 결합 공여자 수
- 10
- 수소 결합 수용자 수
- 14
- 회전 가능 결합 수
- 6
- 무거운 원자 수
- 31
- 형식 전하
- 0
- 복잡도
- 593
물리화학적 성질
- 녹는점
- 192 · 192-195°; mp 175-180° (dec)
- 끓는 점
- 561.28 °C · 561.28°C (rough estimate)
- 밀도
- 1.1751 · 1.1751 (rough estimate)
- 굴절률
- 1.67 · 1.6700 (estimate)
- 저장 조건
- 2 · 2-8°C
- 산도 계수 (pKa)
- 7.7 · 7.70(at 25℃)
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
안전 데이터
- wgk
- 3
- rtecs
- WK2300000
- 독성
- mouse,LD50,intracrebral,66800ug/kg (66.8mg/kg),BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLDLUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION,Kiso to Rinsho. Clinical Report. Vol. 4, Pg. 2489, 1970.
- risk_code
- 61-20/21/22
- hazard_code
- T
- safety_code
- 53-22-36/37/39-45
화학 및 산업
응용 분야
개요Ribostamycin was found in the culture broth of Streptomyces ribosidificus by Meiji Seika Kaisha in 1970 in the course of screening aminoglycoside antibiotics. It is structurally related to neomycin but lacks the diaminoidose (glucose) moiety substituted on the ribose moiety. Ribostamycin is much less toxic than neomycin and shows strong activity against a variety of gram-positive and gram-negative bacteria, except Pseudomonas aeruginosa. It is used parenterally for therapy of urinary tract, respiratory tract, surgical, and other infections.
공급사12 곳
北京华美互利生物化工010-56205725 · [email protected]
成都超九八生物科技有限公司13348960310 13348960310 · [email protected]
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd+86-13119157289 · [email protected]
武汉易泰科技有限公司上海分公司18930552037 · [email protected]
United Life Science020-82099279 18988968278 · [email protected]
湖北扬信医药科技有限公司15347293736 · [email protected]
深圳振强药物研发有限公司+86-0755-66853366 +86-13670046396 · [email protected]
BOC Sciences16314854226; +8616314854226 · [email protected]
浙江珲达生物科技有限公司0571-89903022 18679456698 · [email protected]
陕西缔都医药化工有限公司+86-29-81139210 +86-17392587031 · [email protected]
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