기본 정보
- CAS
756525-99-2- 표준 SMILES
O=C(CCN1C(=O)C=CC1=O)NCCOCCOCCOCCOCCC(=O)ON1C(=O)CCC1=O- InChIKey
XSRYGQJQNPJNKZ-UHFFFAOYSA-N- 분자식
- C22H31N3O11
- 평균 분자량
- 513.5 g/mol
- 단동위원소 질량
- 513.19585881
이름 및 식별자
- 우선 이름
- 1-Maleinimido-3-oxo-7,10,13,16-tetraoxa-4-azanonadecan-19-oic acid succinimidyl ester
- IUPAC
- (2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-[3-(2,5-dioxopyrrol-1-yl)propanoylamino]ethoxy]ethoxy]ethoxy]ethoxy]propanoate
- 현지명
- 알파-말레미도프로피오닐-o메가-숙시니미딜-4(에틸렌글리콜)
- 영어명
- Maleimide-PEG4-NHS Ester
- 분자식
- C22H31N3O11
- 분자량
- 513.49
이름 및 동의어
1-Maleinimido-3-oxo-7,10,13,16-tetraoxa-4-azanonadecan-19-oic acid succinimidyl esterRefChem:433407804-947-8756525-99-2Mal-amido-PEG4-NHSMal-amido-PEG4-NHS ester2,5-dioxopyrrolidin-1-yl 19-(2,5-dioxo-2H-pyrrol-1(5H)-yl)-17-oxo-4,7,10,13-tetraoxa-16-azanonadecan-1-oatemonodisperse Mal-PEG4-NHS-esterMaleimide-PEG4-NHS EsterMFCD11041113Maleimide-NH-PEG4-CH2CH2COONHS EsterAlpha-Maleimidopropionyl-Omega-succinimidyl-4(ethylene glycol)
이름 더 보기
알파-말레미도프로피오닐-o메가-숙시니미딜-4(에틸렌글리콜)Mal-PEG4-NHS2,5-dioxopyrrolidin-1-yl 1-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-3-oxo-7,10,13,16-tetraoxa-4-azanonadecan-19-oateMal-PEG4-SPAN-SuccinimMAL-PEG4-PA-NHSMAL-DPEG4-NHS EsterBMPA-PEG4-NHS Ester
(2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-[3-(2,5-dioxopyrrol-1-yl)propanoylamino]ethoxy]ethoxy]ethoxy]ethoxy]propanoateO-[N-(3-Maleimidopropionyl)aminoethyl]-O inverted exclamation marka-[3-(N-succinimidyloxy)-3-oxopropyl]triethylene glycol3-(2-Maleimidoethylcarbamoyl)-peg4-propionic acid N-hydroxysuccinimide ester3-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-{15-[(2,5-dioxopyrrolidin-1-yl)oxy]-15-oxo-3,6,9,12-tetraoxapentadecan-1-yl}propanamideMal-NH-PEG4-NHSMal-DPEG(4)-NHSAlpha-MaleimidoMAL-NH-PEG4-NHS ESTER
물성
구조 계산 물성
- XLogP
- -2.9
- 극성 표면적
- 167 Ų
- 수소 결합 공여자 수
- 1
- 수소 결합 수용자 수
- 11
- 회전 가능 결합 수
- 20
- 무거운 원자 수
- 36
- 형식 전하
- 0
- 복잡도
- 796
물리화학적 성질
- 밀도
- 1.36 · 1.36±0.1 g/cm3(Predicted)
- 저장 조건
- -20 °C · -20°C
- 용해도
- DMSO에 용해됨
- 물리적 상태
- 고체
- 산도 계수 (pKa)
- 15.01 · 15.01±0.46(Predicted)
- 색상
- White to off-white
- InChI
- InChI=1S/C22H31N3O11/c26-17(5-8-24-18(27)1-2-19(24)28)23-7-10-33-12-14-35-16-15-34-13-11-32-9-6-22(31)36-25-20(29)3-4-21(25)30/h1-2H,3-16H2,(H,23,26)
- InChIKey
- XSRYGQJQNPJNKZ-UHFFFAOYSA-N
- SMILES
- C(ON1C(=O)CCC1=O)(=O)CCOCCOCCOCCOCCNC(=O)CCN1C(=O)C=CC1=O
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
GHS 분류
GHS ClassificationNot Classified
유해성 정보
Hazard Classes and CategoriesNot Classified
안전 데이터
- wgk
- 3
- HS 번호
- 2928009090
- 스토리지 클래스
- 10 - Combustible liquids
화학 및 산업
응용 분야
용도Maleimide-PEG4-NHS (CAS# 756525-99-2) is a cross-linking compound used in the lysosomal acid-triggered release of anticancer drugs.
일반 설명Maleimide-PEG4-NHS Ester (CAS 756525-99-2) is a high-purity, monodisperse polyethylene glycol (PEG) derivative. Its synonyms include Mal-amido-PEG4-NHS, Mal-amido-PEG4-NHS ester, Mal-NH-PEG4-NHS, MAL-NH-PEG4-NHS ESTER and Mal-NH-PEG4-CH₂CH₂COONHS, amongst others. This compound possesses three key functional groups: the Mal group, the PEG4 chain and the NHS ester. The Mal group is capable of forming covalent bonds with thiol groups without affecting the overall structure of the protein; the NHS ester enhances reactivity with primary amine groups, facilitating the formation of stable amide bonds; whilst PEG4 improves the hydrophilicity and biocompatibility of the conjugate, whilst also reducing aggregation and immunogenicity. Consequently, this substance is primarily used in the synthesis of protein conjugates, drug delivery research, diagnostic testing and materials science.
상·하류 제품 정보
상류 원료
공급사100 곳
吉林省创力生物科技有限公司19396231124 19396231124 · [email protected]
浙江博美生物技术有限公司
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