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HCID 5143생성일: 2026년 10월 27일

사카린

사카린 · Benzo[d]isothiazol-3(2H)-one 1,1-dioxide · SACCHARINE · INSOLUBLE SACCHARIN · Sacharin · O-SULFOBENZIMIDE · GLUCID · Sacarina

https://huagongshe.com/ko/chemical/5143

사카린 분자 구조식

식별자 및 물리적 특성

CAS No.81-07-2
분자식C7H5NO3S
평균 분자량183.19 g/mol
단동위원소 질량182.99901402 g/mol
SMILESO=C1NS(=O)(=O)c2ccccc21
InChIKeyCVHZOJJKTDOEJC-UHFFFAOYSA-N
PubChem CID5143
ChEMBLCHEMBL310671
ChEBICHEBI:32111
EC No.201-321-0
DTXSIDDTXSID5021251
현지명사카린

화학 및 물리적 성질

XLogP0.9
극성 표면적71.6
수소 결합 공여자 수1
수소 결합 수용자 수3
회전 가능 결합 수0
무거운 원자 수12
형식 전하0
복잡도303
물질 분류Other Uses -> Food Additives
의약품Pharmaceuticals -> Listed in ZINC15Pharmaceuticals -> Used in Switzerland
화장품MaskingOral care
pHpH of 0.35% aqueous solution: 2.0
SpringerMaterials PropertiesCrystal structure
향료Fragrance Ingredient (Saccharin) -> IFRA transparency List
농약Environmental transformation -> Pesticide transformation products (metabolite, successor)
LogP(분배 계수)log Kow = 0.91
냄새ODORLESS OR HAS FAINT AROMATIC ODOR.냄새 없는
맛In dilute aqueous solution it is 500 times as sweet as sugarsweet taste detectable in 1:100,000 dilution.Bitter, metallic aftertaste
식품 첨가물NON-NUTRITIVE SWEETENER -> FDA Substance added to food
밀도0.828 (NTP, 1992) - Less dense than waterwill float0.828 g/cu cm at 25 °C
녹는점226-229 °C (lit.)
끓는 점subl
증기압0Pa at 25℃
굴절률1.5500 (estimate)
저장 조건Store below +30°C.
용해도아세톤: 12mL(lit.)에 1g이 용해됩니다.
물리적 상태결정 또는 결정성 분말
pKa(산도 계수)11.68(at 18℃)
색상하얀색
용해도3.3g/L(20℃)
Merck14,8311
BRN6888
헨리 상수8.2×103 mol/(m3Pa) at 25℃, HSDB (2015)
안정성안정적인. 강한 산화제와 호환되지 않습니다.
화장품 원료 기능향기구강 관리
InChI1S/C7H5NO3S/c9-7-5-3-1-2-4-6(5)12(10,11)8-7/h1-4H,(H,8,9)
InChIKeyCVHZOJJKTDOEJC-UHFFFAOYSA-N
SMILESO=C1NS(=O)(=O)c2ccccc12
LogP(분배 계수)-0.024 at 25℃
NISTSaccharin(81-07-2)
EPASaccharin (81-07-2)

화학적 성질

Saccharin is a crystalline solid with a sweet taste (500 times sweeter than sugar).

안전 및 규제

GHS 분류This chemical does not meet GHS hazard criteria for 97% (549 of 566) of all reports.Not ClassifiedAggregated GHS information provided per 566 reports by companies from 6 notifications to the ECHA C&L Inventory.
규제 정보Chemical: 1,2-Benzisothiazol-3(2H)-one, 1,1-dioxideCommission Regulation No 844/20121,2-Benzisothiazol-3(2H)-one, 1,1-dioxide is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 1,2-Benzisothiazol-3(2H)-one, 1,1-dioxide are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)Status: Active Update: 12-12-2018 https://echa.europa.eu/registration-dossier/-/registered-dossier/11056Saccharin: Does not have an individual approval but may be used under an appropriate group standardThe New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.)
기타 안전 정보Evaluation - Chemicals that are unlikely to require further regulation to manage risks to environment
화재 위험Flash point data for this chemical are not availablehowever, it is probably combustible. (NTP, 1992)
건강 유해성SYMPTOMS: Symptoms of exposure to this compound include anorexia, nausea, vomiting, diarrhea and gastric hyperacidity. Other symptoms include coughing, chest pain and irritation of the eyes, nose and throat.
유해성 요약May cause irritation[Sigma-Aldrich MSDS]
FDA 요건The food additives saccharin, ammonium saccharin, calcium saccharin, and sodium saccharin may be safely used as sweetening agents in food in accordance with the following conditions /in part 180, section 37/, if the substitution for nutritive sweeteners is for a valid special dietary purpose and is in accord with current special dietary food regulations and policies or if the use or intended use is for an authorized technological purpose other than calorie reduction.Drug products containing certain active ingredients offered over-the-counter (OTC) for certain uses. A number of active ingredients have been present in OTC drug products for various uses, as described below. However, based on evidence currently available, there are inadequate data to establish general recognition of the safety and effectiveness of these ingredients for the specified uses: Saccharin is included in weight control drugs.

용도

용도

It is a non-nutritive sweetener; pharmaceutic aid (flavor). Saccharin was formerly listed as reasonably anticipated to be a human carcinogen; delisted because the cancer data are not sufficient to meet the current criteria for this listing.

일반 설명

White crystals. Odorless or faintly aromatic odor. Sweet taste.

제조 및 합성 방법

제조 방법

Saccharin is synthesized using two methods: the Remsen-Fahlberg process and the Maumee or Sherwin-Williams method. The Remsen-Fahlberg synthesis of saccharin starts by reacting toluene with chlorosulfonic acid to give ortho and para forms of toluene-sulfonic acid (Figure 78.1). The acid can be converted to sulfonyl chlorides by treating with phosphorus pentachloride. The ortho form, o-toluene-sulfonyl chloride, is treated with ammonia to give o-toluene-sulfonamide, which is then oxidized with potassium permanganate to produce o-sulfamido-benzoic acid. On heating, the latter yields saccharin. Another synthesis was developed at Maumee Chemical Company in Toledo, Ohio, and it came to be known as the Maumee process. This process starts with phthalic anhydride, which is converted into anthranilic acid. Anthranilic acid is then reacted with nitrous acid, sulfur dioxide, chlorine, and ammonia to give saccharin. The Maumee process was further refi ned by the Sherwin-Williams Company and is therefore now referred to as the Sherwin-Williams process.

생산 방법

Saccharin is prepared from toluene by a series of reactions known as the Remsen–Fahlberg method. Toluene is first reacted with chlorosulfonic acid to form o-toluenesulfonyl chloride, which is reacted with ammonia to form the sulfonamide. The methyl group is then oxidized with dichromate, yielding o-sulfamoylbenzoic acid, which forms the cyclic imide saccharin when heated. An alternative method involves a refined version of the Maumee process. Methyl anthranilate is initially diazotized to form 2- carbomethoxybenzenediazonium chloride; sulfonation followed by oxidation then yields 2-carbomethoxybenzenesulfonyl chloride. Amidation of this material, followed by acidification, forms insoluble acid saccharin.

반응성 그룹Amides and Imides
Special ReportsToxicity of Food Additives (Excluding Antioxidants), January 1978-July 1989. Govt Reports Announcements & Index (GRA&I) Issue 6 (1990). This bibliography contains citations concerning the toxicity of food additives, incl saccharin, and their effects on the liver, kidneys, bladder, and other organs.Arnold DL, Boyes BGThe Toxicological Effects Of Saccharin in Short-Term Genotoxicity Assays. Mutat Res 221 (2): 69-132 (1989).National Toxicology Program. Eleventh Report on Carcinogens (2005). The Report on Carcinogens is an informational scientific and public health document that identifies and discusses substances (including agents, mixtures, or exposure circumstances) that may pose a carcinogenic hazard to human health. Saccharin (81-07-2) is delisted as reasonably anticipated to be a human carcinogen.[Available from, as of July 31, 2009: http://ntp.niehs.nih.gov/ntp/roc/eleventh/profiles/append/appb.pdf]
TSCA 요건Section 8(a) of TSCA requires manufacturers of this chemical substance to report preliminary assessment information concerned with production, exposure, and use to EPA as cited in the preamble in 51 FR 41329. Effective date 9/29/2006Reporting date: 11/28/2006.Pursuant to section 8(d) of TSCA, EPA promulgated a model Health and Safety Data Reporting Rule. The section 8(d) model rule requires manufacturers, importers, and processors of listed chemical substances and mixtures to submit to EPA copies and lists of unpublished health and safety studies. 1,2-Benzisothiazol-3(2H)-one, 1,1-dioxide is included on this list. Effective date: 9/29/2006Sunset date: 11/28/2006.
Reactivity ProfileAn amide. Acid to litmus. pH of 0.35% aqueous solution: 2.0. Organic amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).
Air and Water ReactionsSlightly soluble in water.
Hazard Classes and CategoriesNot Classified
소화Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)
응급 처치EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.
비화재 누출 대응SMALL SPILLS AND LEAKAGE: If you spill this chemical, you should dampen the solid spill material with water, then transfer the dampened material to a suitable container. Use absorbent paper dampened with water to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.
처리 방법SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air qualitypotential migration in soil or watereffects on animal and plant lifeand conformance with environmental and public health regulations.Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste number U202, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste.A potential candidate for rotary kiln incineration at a temperature range of 820 to 1,600 °C and residence times of seconds for liquids and gases, and hours for solids. A potential candidate for fluidized bed incineration at a temperature range of 450 to 980 °C and residence times of seconds for liquids and gases, and longer for solids.
Preventive MeasuresSRP: In bulk storage or manufacturing situations where combustible dusts can collect in sufficient concentrations to give rise to an explosion/deflagration, reasonable precautions shall be taken to reduce or eliminate the hazard. Efforts shall be made to control or eliminate the five elements necessary to initiate a dust explosion. These include combustible dust (fuel), ignition source (heat), oxygen in air (oxidizer), and dispersion of dust particles in sufficient quantity and concentration as well as confinement of the dust cloud. General guidance in these efforts can be found in OSHA's "Combustible Dust in IndustryPreventing and Mitigating the Effects of Fire and Explosions", which list measures to control dusts, eliminate ignition sources, and limit the effects of explosions.
Personal Protective Equipment (PPE)RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with a combination filter cartridge, i.e. organic vapor/acid gas/HEPA (specific for organic vapors, HCl, acid gas, SO2 and a high efficiency particulate filter). (NTP, 1992)
Other Standards Regulations and GuidelinesIn 1977, the FDA proposed a ban on saccharin because of the discovery of bladder tumors in some male rats fed with high doses of saccharin. Because no other nonnutritive sweetener was available at that time, the proposed ban faced strong opposition. Legislation to stay the ban has been passed in the U.S. Congress periodically. In December, 1991, the FDA withdrew its proposed ban. All saccharin-containing packaged products were required to carry a warning label indicating that saccharin has been determined to cause cancer in laboratory animals. In 2001, the warning label requirement was lifted by the Congress. In 2003, saccharin was delisted from California Proposition 65 (the so-called carcinogen list).
상호 작용IT IS NOW WELL ESTABLISHED THAT THE INTERACTION OF MULTIPLE ENVIRONMENTAL FACTORS MAY INCR THE INCIDENCE OF SOME HUMAN CANCERS MORE THAN EXPOSURE TO A SINGLE CARCINOGEN. WITH AN IN VIVO EXPERIMENTAL RAT MODEL, SYNERGISTIC EFFECT IN BLADDER CARCINOGENESIS BETWEEN A SUBCARCINOGENIC DOSE OF THE STRONG BLADDER CARCINOGEN, N-METHYL-N-NITROSOUREA & SACCHARIN WAS DEMONSTRATED.Since both sodium L-ascorbate and sodium saccharin promote two-stage bladder carcinogenesis in rats, synergism of the two chemicals was investigated with special reference to the role of urinary pH and sodium+ concentration. Male F344 rats were given 0.05% N-butyl-N-(4-hydroxybutyl)nitrosamine in the drinking water for 4 wk and then treated with basal diet containing 5% sodium saccharin, 5% sodium L-ascorbate, 5% sodium saccharin plus 5% sodium L-ascorbate, 5% L-ascorbic acid, 5% sodium saccharin plus 5% L-ascorbic acid, or no added chemical for 32 wk. Treatment with sodium saccharin or sodium L-ascorbate alone significantly increased the induction of neoplastic and preneoplastic lesions of the bladder. Sodium saccharin plus sodium L-ascorbate also induced these bladder lesions significantly when compared with the controls, and the number of lesions was greater than the sum of the lesions in the group treated with sodium saccharin alone or sodium L-ascorbate alone. In contrast, the induction of carcinomas and papillomas in rats treated with sodium saccharin plus sodium L-ascorbate produced an elevation of urinary pH and sodium+ concentrations, although the increases were not different from those in rats fed sodium saccharin or sodium L-ascorbate alone. Sodium saccharin plus L-ascorbic acid, however, did not cause elevation of urinary pH, although it increased urinary sodium+ concentration. Thus, the bladder carcinogenesis promotion by sodium saccharin was synergized by sodium L-ascorbate and inhibited by L-ascorbic acid. This modulation was associated with changes of urinary pH and Na+ concentration. /Sodium saccharin/CHRONIC RAT FEEDING STUDIES WERE CONDUCTED ON A 10:1 CYCLAMATE/SACCHARIN MIXT. THE TEST MIXT WAS FED AT DIETARY LEVELS DESIGNED TO FURNISH 500, 1120, & 2500 MG/KG TO GROUPS OF 35 MALE & 45 FEMALE RATS. THE ONLY POS FINDING WHICH PROVED TO HAVE CRUCIAL SIGNIFICANCE WAS THE OCCURRENCE OF PAPILLARY CARCINOMAS IN THE BLADDERS OF 12 OF THE 70 RATS FED THE MAX DIETARY LEVEL OF THE MIXT (EQUIV TO ABOUT 2500 MG/KG) FOR PERIODS RANGING FROM 78 TO 105 WK.N-METHYL-N-NITROSOUREA WAS USED AS INITIATING CARCINOGEN AND GREATLY INCR YIELD OF BLADDER CANCERS IN SACCHARIN TREATED RATS. SACCHARIN IS A WEAK INITIATOR BUT A POWERFUL PROMOTER OF CARCINOGENESIS IN THE RAT BLADDER.For more Interactions (Complete) data for SACCHARIN (15 total), please visit the HSDB record page.
생태독성 수치LC50Species: Pimephales promelas (fathead minnow, 30 day old)Concentration: 18.3 g/L for 96 hr (confidence limit 16.4 - 20.4 g/L). Dilution factor: 0%, 20%, 40%, 60%, 80% and 100% of the stock solution. Behavioral observations were not recorded. Increased alkalinity values were due to a reaction between the titrant and toxicant. /Saccharin, sodium salt hydrate/
환경 거동TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 23(SRC), determined from a log Kow of 0.91(2) and a regression-derived equation(3), indicates that saccharin is expected to have very mobility in soil(SRC). Volatilization of saccharin from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 1.2X10-9 atm-cu m/mole(SRC), using a fragment constant estimation method(4). The pKa of saccharin is 1.31(5), indicating that this compound will partially exist in the anion form in the environment and anions generally do not adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(6). Saccharin is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 1.0X10-7 mm Hg at 25 °C(SRC), determined from a fragment constant method(7). Incubation experiments with activated sludge resulted in a first order half-life of 90 minutes with 78% removal efficiency after 3 hours(8) suggesting that biodegradation may be an important environmental fate process in soil(SRC).AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 23(SRC), determined from a log Kow of 0.91(2) and a regression-derived equation(3), indicates that saccharin is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(4) based upon an estimated Henry's Law constant of 1.2X10-9 atm-cu m/mole(SRC), developed using a fragment constant estimation method(5). According to a classification scheme(6), an estimated BCF of three(SRC), from its log Kow(2) and a regression-derived equation(2), suggests the potential for bioconcentration in aquatic organisms is low(SRC).Incubation experiments with activated sludge resulted in a first order half-life of 90 minutes with 78% removal efficiency after 3 hours(7) suggesting that biodegradation may be an important environmental fate process in water(SRC).ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), saccharin, which has an estimated vapor pressure of 1.0X10-7 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase saccharin is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC)the half-life for this reaction in air is estimated to be 22 hours(SRC), calculated from its rate constant of 5.9X10-12 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Particulate-phase saccharin may be removed from the air by wet or dry deposition(SRC). Saccharin contains chromophores that absorb at wavelengths >290 nm(4), and therefore may be susceptible to direct photolysis by sunlight(SRC).
Average Daily IntakeThe average daily intake of saccharin through food for the Finnish population was estimated to be 15 mg, based on a survey of the population of Finland(1).
Effluent ConcentrationsSaccharin concentrations in untreated and treated wastewater from the Canton of Zurich, Switzerland, collected in 2008(1). [Table#1945]
Soil Adsorption/MobilityThe Koc of saccharin is estimated as 20(SRC), using a log Kow of 0.91(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that saccharin is expected to have very high mobility in soil. The pKa of saccharin is 1.31(4), indicating that this compound will partially exist in the anion form in the environment and anions generally do not adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(5).
Natural Pollution SourcesSaccharin, sodium and calcium saccharin and o-toluenesulphonamide do not occur as natural products.
Human Toxicity Excerpts/HUMAN EXPOSURE STUDIES/ Randomised, double-blind, placebo-controlled N-of-1 trial with a cross-over design /was conducted in order/ to determine whether there was a connection between the complaint of restless legs and the ingestion of artificial sweeteners in a patient with these symptoms after drinking certain 'light' beverages. During a period of 48 days, the patient took 4 capsules per day containing either 150 mg of cyclamate, 22.5 mg of saccharine, both sweeteners, or placebo on two successive days. Between each of these 2-day periods there was a 2-day rest period during which no capsules were taken. The hospital pharmacist had prepared the capsules and determined the sequence of the 2-day periods on a random basis. The patient did not know which capsules he was taking. Every day on arising, starting 3 weeks before the trial period, the patient noted the intensity and duration of the symptoms in the late evening and previous night. For this notation he used an 11-point scale, from 0 (= no restless legs) to 10 (= almost total inability to sleep because of restless legs). A score of 1-3 corresponded to mild symptoms that had no effect on the patient's sleepat a score of 4-6 his sleep was disturbed and at a score of 7-10 the patient hardly slept at all. The patient had symptoms more often while using saccharine or the combination of saccharine and cyclamate than when taking the placebo (4 and 4 versus 2 of the 6 nights)moreover, the average score was then statistically significantly higher (5.2 and 5.8 versus 3.3). There was a connection between the patient's complaints of restless legs and the use of saccharine, but not the use of cyclamate./CASE REPORTS/ Idiosyncratic effects of saccharin on the liver were reported in a 70-year-old woman. Increased activities of alanine aminotransferase, aspartate aminotransferase, gamma-glutamyl transferase and alkaline phosphatase were found after oral administration of three pharmaceutical drugs of which saccharin was the only common constituent. The drugs were lorazepam, dihydroergocristine and chlordemethyldiazepam. Exposure to saccharin alone reproduced the effects./CASE REPORTS/ ...reported 5 patients in whom oral administration of 0.1 g saccharin caused pruritis and edematous papules on the trunk and limbs./EPIDEMIOLOGY STUDIES/ A SURVEY OF BLADDER CANCER PATIENTS & CONTROLS WITHOUT BLADDER CANCER SHOWED THAT IN GENERAL BLADDER CANCER RISK WAS NOT INCREASED BY NONNUTRITIVE SWEETENER SACCHARIN & CYCLAMATE USE. ADJUSTING FOR SMOKING HABITS, OCCUPATION, AGE, RACE, SEX, DIABETES MELLITUS, ETC DID NOT LEAD TO SIGNIFICANT CORRELATIONS BETWEEN THE SWEETENER USE & BLADDER CANCER.For more Human Toxicity Excerpts (Complete) data for SACCHARIN (11 total), please visit the HSDB record page.
Artificial Pollution SourcesSaccharin's production and use as an artificial, non-nutritive sweetener, pharmaceutic aid (flavor), and in formulations for electroplating-bath brighteners(1) may result in its release to the environment through various waste streams(SRC).
Environmental BiodegradationAEROBIC: The importance of biodegradation of saccharin in soil and water is unknown, but amides are usually susceptible to microbial metabolism(1). Saccharin was eliminated in wastewater treatment plants with activated sludge processes sampled in Zurich Switzerlanda mean removal efficiency of 90% was observed. Incubation experiments with activated sludge resulted in a first order half-life of 90 minutes with 78% removal efficiency after 3 hours. No loss was observed using sterile controls(2).
Carcinogen ClassificationSaccharin and its saltsGroup 3: Not classifiable as to its carcinogenicity to humansVolume Sup 7: Overall Evaluations of Carcinogenicity: An Updating of IARC Monographs Volumes 1 to 42, 1987440 pagesISBN 92-832-1411-0 (out of print)19991998NB Overall evaluation downgraded to Group 3 with supporting evidence from other relevant data
Environmental BioconcentrationAn estimated BCF of three was calculated in fish for saccharin(SRC), using a log Kow of 0.91(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC). Bioconcentration of the substance was tested as a breakdown product of 3-(allyloxy)-1,1-dioxo-1lambda(6),2-benzothiazoleresults indicated low bioconcentration potential(4).
수질 위해 등급(WGK)2
TSCA 등재 상태TSCA listed
RTECS 번호DE4200000
운송 번호(UN)UN 3077 9/PG 3
독성LD50 oral in mouse: 17gm/kg
관세 코드29251100
위험 문구(R)40-62-63-68
안전 문구(S)24/25
위험 등급IRRITANT
기존화학 물질KE-02681
저장 분류11 - Combustible Solids
유해 물질 데이터81-07-2(Hazardous Substances Data)