다이카프릴소듐설포석시네이트

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

20 [mg/m3]

63 [mg/m3]

380 [mg/m3]

Chemical goggles; rubber gloves; dust respirator. (USCG, 1999)

Chemical goggles; rubber gloves; dust respirator.

The CIR Expert Panel concluded that the following 8 dialkyl sulfosuccinate salts are safe in the present practices of use and concentration in cosmetics in this safety assessment when formulated to be non-irritating...Dicapryl Sodium Sulfosuccinate...

Safe for use in cosmetics, with qualifications

Ingestion causes diarrhea and intestinal bloating.

The docusates are well tolerated. Cramping pains have been reported occasionally, and the liquid preparations sometimes cause nausea. /Docusates/

Of particular concern are the observations that docusate sodium is absorbed, appears in the bile in significant conc, and has cytotoxic effects on liver cells in tissue culture.

Water and salt accumulated in ligated colonic segments of DSS-treated rats whereas net absorption of isotonic saline solution occurred in control rats. When segments of rodent ileum, jejunum and colon were perfused with 0.5 mM DSS, mucosal cells were flattened and their brush borders disappeared. ... Only diarrhea and intestinal bloating are reported in animals given toxic doses.

In chronic feeding tests, fatally poisoned rats showed no gross lesions outside of the GI.

Eye irritation may be caused by solutions containing more than 0.1% DSS.

Chemical: Butanedioic acid, sulfo-, 1,4-dioctyl ester, sodium salt

2002/2076

Di-n-octyl sodium sulfosuccinate: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.