2,4-티아졸리딘디온,5-[(4-히드록시페닐)메틸렌]-
5-((4-Hydroxyphenyl)methylene)-2,4-thiazolidinedione
기본 정보
- CAS
103788-60-9- 표준 SMILES
O=C1NC(=O)C(=Cc2ccc(O)cc2)S1- InChIKey
ARHIHDVVUHVQCP-UHFFFAOYSA-N- 분자식
- C10H7NO3S
- 평균 분자량
- 221.23 g/mol
이름 및 식별자
- 우선 이름
- 5-((4-Hydroxyphenyl)methylene)-2,4-thiazolidinedione
- IUPAC
- 5-[(4-hydroxyphenyl)methylidene]-1,3-thiazolidine-2,4-dione
- 현지명
- 2,4-티아졸리딘디온,5-[(4-히드록시페닐)메틸렌]-
- 영어명
- 2,4-Thiazolidinedione, 5-[(4-hydroxyphenyl)methylene]-
- 분자식
- C10H7NO3S
- 분자량
- 221.23
이름 및 동의어
103788-60-95-((4-Hydroxyphenyl)methylene)-2,4-thiazolidinedioneRefChem:10723145-(4-hydroxybenzylidene)thiazolidine-2,4-dione5-[(4-hydroxyphenyl)methylidene]-1,3-thiazolidine-2,4-dioneMFCD00640639154052-92-35-[(E)-(4-hydroxyphenyl)methylidene]-1,3-thiazolane-2,4-dione(Z)-5-(4-Hydroxybenzylidene)thiazolidine-2,4-dioneMFCD007110762,4-Thiazolidinedione, 5-[(4-hydroxyphenyl)methylene]-, (5Z)-CBMicro_020528
이름 더 보기
2,4-티아졸리딘디온,5-[(4-히드록시페닐)메틸렌]-Pioglitazone Impurity 425-(4-hydroxybenzylidene)-2,4-thiazolidinedione5-[(4-hydroxyphenyl)methylene]-2,4-Thiazolidinedione2,4-Thiazolidinedione, 5-[(4-hydroxyphenyl)methylene]-(Z)-5-(4-hydroxybenzylidene)thiazolidine-2,4-dione(WX180325)Pioglitazone impurity 5-(4-Hydroxybenzylidene)thiazolidine-2,4-dione
SCHEMBL621991SCHEMBL4862901ARHIHDVVUHVQCP-UHFFFAOYSA-NHMS3380A10AKOS030240083SY129798DB-059050W15187
데이터베이스 식별자
- CAS
103788-60-9- PubChem CID
- 517822
- EC Number
- 104-841-5
물성
구조 계산 물성
- XLogP
- 1.8
- 극성 표면적
- 91.7 Ų
- 수소 결합 공여자 수
- 2
- 수소 결합 수용자 수
- 4
- 회전 가능 결합 수
- 1
- 무거운 원자 수
- 15
- 형식 전하
- 0
- 복잡도
- 319
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
GHS 분류
GHS Classification
Warning
H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
P264+P265, P280, P305+P351+P338, and P337+P317 (click each P-code to see the statement)
The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
유해성 정보
Hazard Classes and CategoriesEye Irrit. 2 (100%)
안전 데이터
- 위험 등급
- IRRITANT
화학 및 산업
응용 분야
용도5-[(4-Hydroxyphenyl)methylene]-2,4-thiazolidinedione is a 5-Benzylidene-2,4-thiazolidenedione derivative designed as inhibitors of angiogenesis targeting VEGFR-2. Also, it is an intermediate used in the synthesis of MSDC 0602 (M755420), which is an analogue ofthiazolidinediones, exhibits low affinity for binding and activation of peroxisome proliferator-activated receptor γ (PPARγ). Thiazolidinediones are effective insulin-sensitizing drugs for treating various metabolic and inflammatory diseases.
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