9[3[(1메틸에틸)아미노]프로필]-플루오렌-9-카르복사미드

Indecainide

HCID 52195CAS 74517-78-5

부분 구조 검색 유사 구조 찾기

기본 정보

표준 SMILES: CC(C)NCCCC1(C(N)=O)c2ccccc2-c2ccccc21
InChIKey: UCEWGESNIULAGX-UHFFFAOYSA-N
분자식: C20H24N2O
평균 분자량: 308.4 g/mol
단동위원소 질량: 308.18886339

개요

Indecainide is a member of fluorenes.

이름 및 식별자

우선 이름: Indecainide
IUPAC: 9-[3-(propan-2-ylamino)propyl]fluorene-9-carboxamide
현지명: 9[3[(1메틸에틸)아미노]프로필]-플루오렌-9-카르복사미드
영어명: 9[3[(1methylethyl)amino]propyl]-fluorene-9-carboxamide
분자식: C20H24N2O
분자량: 308.41736

이름 및 동의어

INDECAINIDE74517-78-5IndecainidaIndecainidumDTXSID20578193AZF20DM1TDTXCID30316089-{3-[(propan-2-yl)amino]propyl}-9H-fluorene-9-carboxamide9-(3-((1-methylethyl)amino)propyl)-9H-fluorene-9-carboxamide9-(3-((propan-2-yl)amino)propyl)-9H-fluorene-9-carboxamideRefChem:148111Ricainid

이름 더 보기

9[3[(1메틸에틸)아미노]프로필]-플루오렌-9-카르복사미드Ccris 2655

RicainideIndecainidum [Latin]Indecainida [Spanish]Indecainide [INN]9-[3-(propan-2-ylamino)propyl]fluorene-9-carboxamide9-(3-(Isopropylamino)propyl)-9-fluorenylcarboxamid9-(3-(Isopropylamino)propyl))fluorene-9-carboxamide9-(3-(Isopropylamino)propyl)-9H-fluorene-9-carboxamide

데이터베이스 식별자

CAS: 74517-78-5
PubChem CID: 52195
DTXSID: DTXSID2057819
ChEMBL: CHEMBL1201242
ChEBI: CHEBI:135314
UNII: 3AZF20DM1T
Nikkaji: J32.491D

물성

구조 계산 물성

XLogP: 3
극성 표면적: 55.1 Å²
수소 결합 공여자 수: 2
수소 결합 수용자 수: 2
회전 가능 결합 수: 6
무거운 원자 수: 23
형식 전하: 0
복잡도: 398

실험 및 물리화학적 성질

DrugsPharmaceuticals -> Listed in ZINC15

LogP3.8

Solubility8.96e-04 g/L

Melting Point · 2건

94-95 °C

94 - 95 °C

Physical DescriptionSolid

물리화학적 성질

녹는점: 94 · 94-95°

화학 및 산업

약리 정보

Pharmacodynamics · 1건

Indecainide is a rarely used antidysrhythmic. Indecainide has local anesthetic activity and belongs to the membrane stabilizing (Class 1) group of antiarrhythmic agents; it has electrophysiologic effects characteristic of the IC class of antiarrhythmics.

Mechanism of ActionIndecainide acts on sodium channels on the neuronal cell membrane, limiting the spread of seizure activity and reducing seizure propagation. The antiarrhythmic actions are mediated through effects on sodium channels in Purkinje fibers.

Absorption, Distribution and ExcretionNearly complete following oral administration.

Cellular LocationsMembrane