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기본 정보
- CAS
98631-95-9- 표준 SMILES
CC(C)COC(=O)OCN1C(=O)CN(CCN2CC(=O)N(COC(=O)OCC(C)C)C(=O)C2)CC1=O- InChIKey
OCOKWVBYZHBHLU-UHFFFAOYSA-N- 분자식
- C22H34N4O10
- 평균 분자량
- 514.532 g/mol
- 단동위원소 질량
- 514.22749329
이름 및 식별자
- 우선 이름
- Sobuzoxane
- IUPAC
- (Ethane-1,2-diyl)bis[(2,6-dioxopiperazine-4,1-diyl)methylene] bis(2-methylpropyl) biscarbonate
- 현지명
- 소부족산
- 영어명
- Sobuzoxane
- 분자식
- C22H34N4O10
- 분자량
- 514.53
이름 및 동의어
소부족산e)(ester)SobuzoxanePerazolineSobuzoxane/MST 16methylpropyl)ester1,2-bis(4-isobutoxycarbonyloxymethyl-3,5-dioxo-piperazin-1-yl)ethane4,4’-ethylenebis(1-(hydroxymethyl)-2,6-piperazinedione)bis(isobutylcarbonat1,2-ethanediylbis((2,6-dioxo-4,1-piperazinediyl)methylene)bis(2-carbonicaci4,4'-Ethylenebis(2,6-dioxopiperazine-1-methanol)bis(2-methylpropoxyformate)MST-16, 4,4μ-(1,2-Ethanediyl)bis(1-isobutoxycarbonyloxmethyl-2,6-piperazinedione)
데이터베이스 식별자
- CAS
98631-95-9- PubChem CID
- 5233
- DTXSID
DTXSID5045203- ChEMBL
CHEMBL1256871- ChEBI
CHEBI:32136- UNII
- R1308VH37P
- Nikkaji
- J269.578B
물성
물리화학적 성질
- 녹는점
- 128 · 128-130°; mp 132-133° (Cai, 1989)
- 끓는 점
- 664.9 · 664.9±55.0 °C(Predicted)
- 밀도
- 1.272 · 1.272±0.06 g/cm3(Predicted)
- 용해도
- 19 mg/mL · DMSO: 19mg/mL
- 물리적 상태
- 고체
- 산도 계수 (pKa)
- 2.75 · 2.75±0.20(Predicted)
- 색상
- White to off-white
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
안전 데이터
- wgk
- 2
- rtecs
- FG1582500
- 독성
- LD50 in male, female mice, rats (mg/kg): 807, 960, 877, 567 i.p.; 400, 673, 3025, 2821 s.c.; >5 g/kg orally in all species (Tokiwa)
화학 및 산업
응용 분야
개요Sobuzoxane, a novel bis(2,6-dioxopiperazine) derivative, was introduced in Japan for the treatment of malignant lymphoma and adult T-cell IeukemiaQmphoma (ATLL), which is resistant to chemotherapy and has a poor prognosis. Sobuzoxane exhibits 8 broad spectrum of antitumor activity. It is a noncleavable complexstabilizing topoisomerase II inhibitor and exerts its function via interfering with the catalytic activity of the enzyme to result in an irreversible inhibition of cell division by blockade of chromosome condensation and segregation. Due to Its unique mode of cytocidai activity, it has no cross resistance with many currently available anticancer agents. Sobuzoxane is reported to significantly inhibit growth of human colon, lung, gastric, and breast cancers and is in clinical trials for these indications.
용도Sobuzoxane is an inhibitor of DNA topoisomerase II which induces apoptosis.
공급사6 곳
Aladdin Scientific[email protected]
LGM Pharma1-(800)-881-8210 · [email protected]
TargetMol 中国（陶术生物）400-821-0310 15002144251 · [email protected]
武汉杂环科技有限公司027-88041443 13072715837 · [email protected]
南通全益生物科技有限公司0513-66337626 18051384581 · [email protected]
重庆卡兰医药有限公司[email protected]
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