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Breast Feeding; Lactation; Milk, Human; Antihistamines; Antipruritics

FDA approved drugs -> Active ingredient

FDA approved drugs -> Active ingredient

This chemical does not meet GHS hazard criteria for 0.8% (2 of 241) of reports.

Danger

H301 (87.6%): Toxic if swallowed [Danger Acute toxicity, oral]

P260, P261, P262, P264, P264+P265, P270, P271, P280, P301+P316, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P319, P321, P330, P361+P364, P363, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 241 reports by companies from 19 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Danger

SYMPTOMS: Symptoms of exposure to this compound may include drowsiness, dizziness, sleeplessness, nervousness and excitability. Other symptoms may include sensitivity reactions, dry mouth, weakness, anorexia, nausea, vomiting headache, hypotension, polyuria, heartburn, diplopia, dysuria, blurred vision and dermatitis. Exposure to large amounts may lead to hallucinations, convulsions or death, especially in infants and children. There has been one report of left-sided blepharospasm and dyskinesia on the left side of the face. Other symptoms may include central nervous system depression, local anesthesia, skin sensitization, dryness of the nose and throat, abdominal pain and diarrhea. A dulling of mental alertness may also occur.

An acidic salt of an organic amine. Materials in this group are generally soluble in water, though some also may react with water. The resulting solutions contain moderate concentrations of hydrogen ions and have pHs of less than 7.0. Compounds in this group react as weak acids to neutralize bases. These neutralizations generate heat, but less than is generated by neutralization of inorganic acids, inorganic oxoacids, or carboxylic acids. Many of these compounds catalyze organic reactions.

Acute Tox. 3 (87.6%)

Acute toxicity (Oral) - Category 4

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. If symptoms (such as redness or irritation) develop, immediately transport the victim to a hospital.

SMALL SPILLS AND LEAKAGE: If you spill this chemical, you should dampen the solid spill material with water, then transfer the dampened material to a suitable container. Use absorbent paper dampened with water to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)

Chlorpheniramine Maleate

TR-317: Toxicology and Carcinogenesis Studies of Chlorpheniramine Maleate (CASRN 113-92-8) in F344/N Rats and B6C3F1 Mice (Gavage Studies) (1986 )

12/09/85

No Evidence

No Evidence

No Evidence

Drug Induced Liver Injury Rank (DILIrank 2.0)

Chlorpheniramine maleate

vNo-DILI-concern

0

No match

DOI:10.1016/j.drudis.2016.02.015

CHLORPHENIRAMINE MALEATE

Histamine-1 Receptor Antagonist [EPC]; Histamine H1 Receptor Antagonists [MoA]

CHLORPHENIRAMINE MALEATE 4MG

Histamine-1 Receptor Antagonist [EPC]; Histamine H1 Receptor Antagonists [MoA]

Agents, usually topical, that relieve itching (pruritus).

Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood.

Agents that are used to treat allergic reactions. Most of these drugs act by preventing the release of inflammatory mediators or inhibiting the actions of released mediators on their target cells. (From AMA Drug Evaluations Annual, 1994, p475)