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기본 정보
- CAS
132203-70-4- 표준 SMILES
COCCOC(=O)C1=C(C)NC(C)=C(C(=O)OC/C=C/c2ccccc2)C1c1cccc([N+](=O)[O-])c1- InChIKey
KJEBULYHNRNJTE-DHZHZOJOSA-N- 분자식
- C27H28N2O7
- 평균 분자량
- 492.528 g/mol
- 단동위원소 질량
- 492.18965124
이름 및 식별자
- 우선 이름
- Cilnidipine
- IUPAC
- 2-Methoxyethyl (2E)-3-phenylprop-2-en-1-yl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
- 영어명
- Cilnidipine
- 분자식
- C27H28N2O7
- 분자량
- 492.52
이름 및 동의어
CiLclinidipineATELECCINALONGSISCARDFRC-8653SidipineFRG 8653nidipineilnidipine
데이터베이스 식별자
- CAS
132203-70-4、132295-21-7、132338-87-5- PubChem CID
- 5282138
- DTXSID
DTXSID0046309- ChEMBL
CHEMBL452076- ChEBI
CHEBI:31399- UNII
- 4LNU2SU262、97T5AZ1JIP、S85436ZG85
- EC Number
- 634-350-6
- Nikkaji
- J326.004F
물성
물리화학적 성질
- 녹는점
- 97 · 97-99°C
- 끓는 점
- 652.6 · 652.6±55.0 °C(Predicted)
- 밀도
- 1.24 · 1.240±0.06 g/cm3(Predicted)
- 저장 조건
- Keep in dark place,Sealed in dry,Room Temperature
- 용해도
- 2 O: · H2O: 2mg/mL 이하
- 산도 계수 (pKa)
- 2.61 · 2.61±0.70(Predicted)
- 물리적 상태
- 가루
- 색상
- 연노랑
- 수용성
- 2 O: · H2O: ≤2mg/mLDMSO: ≥20mg/mL
- Merck
- 14 · 14,2275
- InChI
- 1S/C27H28N2O7/c1-18-23(26(30)35-14-8-11-20-9-5-4-6-10-20)25(21-12-7-13-22(17-21)29(32)33)24(19(2)28-18)27(31)36-16-15-34-3/h4-13,17,25,28H,14-16H2,1-3H3/b11-8+
- InChIKey
- KJEBULYHNRNJTE-DHZHZOJOSA-N
- SMILES
- C1(C)NC(C)=C(C(OC/C=C/C2=CC=CC=C2)=O)C(C2=CC=CC([N+]([O-])=O)=C2)C=1C(OCCOC)=O
화학적 성질
Yellow Crystalline Solid
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
안전 데이터
- wgk
- 3
- rtecs
- US7975550
- 독성
- LD50 in male, female mice, rats (mg/kg): 5000, 5000, 5000, 4412 orally; 5000 all species s.c.; 1845, 2353, 441, 426 i.p. (Wada)
- HS 번호
- 29333990
- risk_code
- 41
- hazard_code
- Xi
- safety_code
- 26-39
- Hazard Classifications
- Eye Dam. 1
- 스토리지 클래스
- 11 - Combustible Solids
화학 및 산업
응용 분야
개요Cilnidipine is a dihydropyridine calcium antagonist introduced for the treatment of essential and severe hypertension and hypertension associated with renopathy. Cilnidipine has been demonstrated to exert a potent vasodilating effect by blocking calcium influx via dihydropyridine-sensitive, voltage-dependent calcium channels. Compared to nifedipine and nicardipine, cilnidipine is superior, especially for long-term treatment, due to its characteristics of slow onset and long duration with less cardiodepressant activity. Cilnidipine is reportedly well tolerated with low toxicity. It may also be useful in ischemic heart disease.
용도Cilnidipine has been used:in cell viability assay of pheochromocytoma (nPC12) cellsin photoirradiation and photodegradation studies to understand effect on albuminuria in diabetic nephropathy
상·하류 제품 정보
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추가 설명
정의ChEBI: A diesterified 1,4-dihydropyridine-3,5-dicarboxylic acid. A calcium channel blocker, it is used as an antihypertensive.
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