Gamma-Tocotrienol

HCID 5282349CAS 14101-61-2
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기본 정보

표준 SMILES
CC(C)=CCC/C(C)=C/CC/C(C)=C/CC[C@]1(C)CCc2cc(O)c(C)c(C)c2O1
InChIKey
OTXNTMVVOOBZCV-WAZJVIJMSA-N
분자식
C28H42O2
평균 분자량
410.6 g/mol
단동위원소 질량
410.31848058

이름 및 식별자

우선 이름
Gamma-Tocotrienol
IUPAC
(2R)-2,7,8-trimethyl-2-[(3E,7E)-4,8,12-trimethyltrideca-3,7,11-trienyl]-3,4-dihydrochromen-6-ol
영어명
D-gamma-Tocotrienol
분자식
C28H42O2
분자량
410.63

이름 및 동의어

gamma-Tocotrienol14101-61-2185QAE24TRJ13.903C(2R)-2,7,8-trimethyl-2-[(3E,7E)-4,8,12-trimethyltrideca-3,7,11-trienyl]-3,4-dihydrochromen-6-olCHEBI:33277DTXSID1010199842H-1-Benzopyran-6-ol, 3,4-dihydro-2,7,8-trimethyl-2-(4,8,12-trimethyl-3,7,11-tridecatrienyl)-, (R-(E,E))-2H-1-BENZOPYRAN-6-OL, 3,4-DIHYDRO-2,7,8-TRIMETHYL-2-((3E,7E)-4,8,12-TRIMETHYL-3,7,11-TRIDECATRIEN-1-YL)-, (2R)-2H-1-Benzopyran-6-ol, 3,4-dihydro-2,7,8-trimethyl-2-(4,8,12-trimethyl-3,7,11-tridecatrienyl)-, [R-(E,E)]-2R,7,8-trimethyl-2-[(3E,7E)-4,8,12-trimethyltrideca-3,7,11-trien-1-yl]-3,4-dihydro-2H-chromen-6-oltocotrienol, gamma
이름 더 보기
γ-Tocotrienolγ-TocotrienolD-G-TOCOTRIENOLD-γ-TocotrienolGama-Tocotrienol(R)-gamma-Tocotrienol(-)-gamma-TocotrienolTOCOTRIENOL, D-GAMMA-Senecionine Impurity 4
(2R)-2,7,8-trimethyl-2-((3E,7E)-4,8,12-trimethyltrideca-3,7,11-trienyl)-3,4-dihydrochromen-6-ol2H-1-Benzopyran-6-ol, 3,4-dihydro-2,7,8-trimethyl-2-[(3E,7E)-4,8,12-trimethyl-3,7,11-tridecatrien-1-yl]-, (2R)-2R,7,8-trimethyl-2-((3E,7E)-4,8,12-trimethyltrideca-3,7,11-trien-1-yl)-3,4-dihydro-2H-chromen-6-olRefChem:639608DTXCID901477841plastochromanol 8, plastochromanol 3604-216-1D-gamma-Tocotrienol

데이터베이스 식별자

CAS
14101-61-2
PubChem CID
5282349
DTXSID
DTXSID101019984
ChEMBL
CHEMBL120697
ChEBI
CHEBI:33277
UNII
185QAE24TR
EC Number
604-216-1
Nikkaji
J13.903C

물성

구조 계산 물성

XLogP
8.9
극성 표면적
29.5 Ų
수소 결합 공여자 수
1
수소 결합 수용자 수
2
회전 가능 결합 수
9
무거운 원자 수
30

실험 및 물리화학적 성질

Physical DescriptionSolid
Kovats Retention Index · 2건

3170.9

3083

물리화학적 성질

끓는 점
530.8 · 530.8±49.0 °C(Predicted)
밀도
0.964 · 0.964±0.06 g/cm3(Predicted)
저장 조건
20 °C · −20°C
용해도
클로로포름(약간 용해됨), 에틸아세테이트(약간 용해됨), 메탄올(약간 용해됨)
물리적 상태
Liquid
산도 계수 (pKa)
11.05 · 11.05±0.40(Predicted)

화학적 성질

g:d:aTocotrienol 1.6:0.4:1

안전 및 규제

GHS 분류

GHS Classification · 3건

This chemical does not meet GHS hazard criteria for 100% (104 of 104) of all reports.

Not Classified；Reported as not meeting GHS hazard criteria by 104 of 104 companies. For more detailed information, please visit ECHA C&L website.

Aggregated GHS information provided per 104 reports by companies from 1 notifications to the ECHA C&L Inventory.；Reported as not meeting GHS hazard criteria per 104 of 104 reports by companies.；There are 0 notifications provided by 0 of 104 reports by companies with hazard statement code(s).；Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

유해성 정보

Hazard Classes and CategoriesNot Classified

안전 데이터

wgk
2
스토리지 클래스
10 - Combustible liquids

화학 및 산업

약리 정보

Cellular LocationsExtracellular；Membrane
응용 분야 · 2건

개요γ-Tocotrienol is a form of vitamin E that has been found in rice bran and has diverse biological activities. It reduces cell death induced by hydrogen peroxide, paraquat, S-nitrocysteine, SIN-1 , or L-buthionine-(S,R)-sulfoximine (BSO; ) in rat striatal cultures when used at concentrations ranging from 0.1 to 10 μM. γ-Tocotrienol (20 μM) induces apoptosis in malignant sympathoadrenal (+SA) mouse mammary epithelial cells. In vivo, γ-tocotrienol (15, 30, and 150 mg/kg) reduces blood pressure and plasma lipid peroxide levels in spontaneously hypertensive rats. [Matreya, LLC. Catalog No. 2111]

용도γ-Tocotrienol exhibits antioxidant properties and belongs to the vitamin E family. It is naturally found in wheat germ oil and bran. In addition, α-tocopherol and γ-tocotrienol derivatives are potential lead compounds for developinganticancer andantiproliferative agents againstMCF-7 and MDA-MB-231 breast cancer cells and the A549 lung cancer cells.

공급사50 곳

南京世洲生物科技有限公司025-85560043 15850508050 · [email protected]
上海惠诚生物科技有限公司60498804 18930850192 · [email protected]
Career Henan Chemica Co+86-0371-86658258 +86-13203830695 · [email protected]
武汉英诺医药科技有限公司+86-027-59232304 15387063101 · [email protected]
成都超九八生物科技有限公司13348960310 13348960310 · [email protected]

추가 설명

정의ChEBI: A tocotrienol that is chroman-6-ol substituted by methyl groups at positions 2, 7 and 8 and a farnesyl chain at position 2.

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4건
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