기본 정보
- CAS
130773-02-3- 표준 SMILES
CCCCCOc1ccccc1/C(=C\SC)n1ccnc1.Cl- InChIKey
HAHMABKERDVYCH-ZUQRMPMESA-N- 분자식
- C17H23ClN2OS
- 평균 분자량
- 338.9 g/mol
- 단동위원소 질량
- 338.1219622
개요
Neticonazole hydrochloride is a hydrochloride resulting from the formal reaction of equimolar amounts of neticonazole and hydrogen chloride. An inhibitor of P450-dependent C-14alpha-demethylation of lanosterol (preventing conversion to ergosterol and inhibiting cell wall synthesis in fungi), it is used in Japan as an antifungal drug for the treatment of superficial skin infections. It has a role as an EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor and an antifungal drug. It is a hydrochloride, an imidazole antifungal drug and a conazole antifungal drug. It contains a neticonazole(1+).
이름 및 식별자
- 우선 이름
- Neticonazole Hydrochloride
- IUPAC
- 1-[(E)-2-methylsulfanyl-1-(2-pentoxyphenyl)ethenyl]imidazole;hydrochloride
- 현지명
- 1-[2-메틸설파닐-1-(2-펜톡시페닐)에테닐]이미다졸염산염
- 영어명
- Neticonazole Hydrochloride
- 분자식
- C17H23ClN2OS
- 분자량
- 338.9
이름 및 동의어
neticonazole hydrochloride130773-02-3SS717PKF582ZH6PSS-717CHEBI:31900SS 717RefChem:165543Neticonazole HClNeticonazole hydrochloride [JAN]Neticonazole (hydrochloride)(E)-1-(2-(Methylthio)-1-(2-(pentyloxy)phenyl)vinyl)-1H-imidazole hydrochloride
이름 더 보기
1-[2-메틸설파닐-1-(2-펜톡시페닐)에테닐]이미다졸염산염Atolant1-[2-methylsulfanyl-1-(2-pentoxyphenyl)ethenyl]imidazole hydrochloride1-[(E)-2-methylsulfanyl-1-(2-pentoxyphenyl)ethenyl]imidazole,hydrochloridelong-acting,colorectal,Neticonazole,antifungal,Neticonazole Hydrochloride,Imidazole,anti-cancer,nSMase2,Fungal,secretion,Inhibitor,p-ERK,anti-infection,inhibit,exosome
1-[(E)-2-methylsulfanyl-1-(2-pentoxyphenyl)ethenyl]imidazole;hydrochlorideNeticonazole hydrochloride (JAN)C17H23ClN2OSUNII-PKF582ZH6PNewralAtolant (TN)(E)-(1-(2-Pentyloxyphenyl)-1-imidazolyl-2-methylthio)ethylene hydrochloride(E)-1-(2-(Methylthio)-1-(2-(pentyloxy)phenyl)ethenyl)-1H-imidazole monohydrochloride
물성
구조 계산 물성
- 극성 표면적
- 52.4 Ų
- 수소 결합 공여자 수
- 1
- 수소 결합 수용자 수
- 3
- 회전 가능 결합 수
- 8
- 무거운 원자 수
- 22
- 형식 전하
- 0
- 복잡도
- 322
물리화학적 성질
- 녹는점
- 145 · 145-147°
- 저장 조건
- -20 °C · Store at -20°C
- 용해도
- 250 mg/mL · DMSO: 250 mg/mL (737.68 mM)
- 물리적 상태
- Solid
- 색상
- White to off-white
화학 및 산업
응용 분야
개요Neticonazole hydrochloride is a novel imidazole antifungal agent introduced for the treatment of infections caused by Candida species. One percent neticonazole cream oncedaily application has been reported to be effective in treating patients with tinea pedis, tinea corporis, tinea cruris, intertrigo-type candidiasis, erosio interdigitalis and tinea versicolor. Compared with other agents of the azole class, neticonazole has the most potent activity against a variety of fungi, including the dermatophytes and pathogenic yeasts. It also has activity against Gram-positive, but not Gram-negative bacteria.
상·하류 제품 정보
상류 원료
공급사54 곳
Career Henan Chemica Co+86-0371-86658258 +86-13203830695 · [email protected]
武汉英诺医药科技有限公司+86-027-59232304 15387063101 · [email protected]
成都超九八生物科技有限公司13348960310 13348960310 · [email protected]
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