기본 정보
- CAS
7104-38-3- 표준 SMILES
COc1ccc2c(c1)N(C[C@H](C)CN(C)C)c1ccccc1S2.O=C(O)/C=C\C(=O)O- InChIKey
IFLZPECPTYCEBR-VIEYUMQNSA-N- 분자식
- C23H28N2O5S
- 평균 분자량
- 444.5 g/mol
- 단동위원소 질량
- 444.17189317
개요
Methotrimeprazine is only found in individuals that have used or taken this drug. It is a phenothiazine with pharmacological activity similar to that of both chlorpromazine and promethazine. It has the histamine-antagonist properties of the antihistamines together with central nervous system effects resembling those of chlorpromazine. (From Martindale, The Extra Pharmacopoeia, 30th ed, p604). Methotrimeprazine's antipsychotic effect is largely due to its antagonism of dopamine receptors in the brain. In addition, its binding to 5HT2 receptors may also play a role.
이름 및 식별자
- 우선 이름
- Methotrimeprazine maleate
- IUPAC
- (Z)-but-2-enedioic acid;(2R)-3-(2-methoxyphenothiazin-10-yl)-N,N,2-trimethylpropan-1-amine
- 영어명
- Levomepromazine maleate
- 분자식
- C19H24N2OS.C4H4O4
- 분자량
- 444.55
이름 및 동의어
levomepromazine maleate7104-38-3Methotrimeprazine maleateMinozinanNeuractilNeurocilMilezinSofminMethoprazineHirnaminLevomepromazine Hydrogen MaleateDTXSID4045399
이름 더 보기
NeruocilLevohalteNeurocil (tablet)Levomepromazine meleateRP 7044 hydrogen maleateLevomepromazine·maleic acidLevomepromazine maleate CRS
Veractil5KN5Y9V01KDTXCID202539910H-Phenothiazine-10-propanamine, 2-methoxy-N,N,beta-trimethyl-, (betaR)-, (2Z)-2-butenedioate (1:1)LevinanRefChem:799026(2R)-3-(2-Methoxy-10H-phenothiazin-10-yl)-N,N,2-trimethylpropylamine monomaleate230-412-8
데이터베이스 식별자
- CAS
7104-38-3- PubChem CID
- 5282484
- DTXSID
DTXSID4045399- ChEMBL
CHEMBL1725730- UNII
- 5KN5Y9V01K
- EC Number
- 230-412-8
물성
구조 계산 물성
- 극성 표면적
- 116 Ų
- 수소 결합 공여자 수
- 2
- 수소 결합 수용자 수
- 8
- 회전 가능 결합 수
- 7
- 무거운 원자 수
- 31
- 형식 전하
- 0
- 복잡도
- 497
물리화학적 성질
- 녹는점
- 176 · 176-179°C
- 저장 조건
- -20 °C · -20°C Freezer
- 용해도
- 클로로포름(약간 용해됨), DMF(약간 용해됨), 메탄올(약간 용해됨)
- 물리적 상태
- solid
- 색상
- 미색부터 페일 베이지까지
- 주요 응용
- 의약품(소분자)
- InChIKey
- IFLZPECPTYCEBR-VIEYUMQNSA-N
- SMILES
- S1c2c(cc(cc2)OC)N(c3c1cccc3)C[C@@H](CN(C)C)C.OC(=O)\C=C/C(=O)O
화학적 성질
Pale Beige Solid
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
GHS 분류
GHS Classification
Warning
H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
P261, P264, P264+P265, P270, P272, P273, P280, P301+P317, P302+P352, P305+P351+P338, P321, P330, P333+P317, P337+P317, P362+P364, P391, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 34 reports by companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
유해성 정보
Regulatory InformationMethotrimeprazine maleate: Does not have an individual approval but may be used under an appropriate group standard
Other Safety InformationIMAP assessments - 10H-Phenothiazine-10-propanamine, 2-methoxy-N,N,.beta.-trimethyl-, (Z)-2-butenedioate (1:1), (-)-: Human health tier I assessment
Hazard Classes and CategoriesAcute Tox. 4 (100%)
독성 정보
Exposure RoutesOral; parental (intramuscular). Methotrimeprazine has an incomplete oral bioavailability, because it undergoes considerable first-pass-metabolism in the liver. Oral bioavailability is approximately 50 to 60%.
Toxicity Summary
Methotrimeprazine's antipsychotic effect is largely due to its antagonism of dopamine receptors in the brain. In addition, its binding to 5HT2 receptors may also play a role. Methotrimeprazine exerts its actions through a central adrenergic-blocking, a dopamine-blocking, a serotonin-blocking, and a anticholinergic blocking.
Signs and SymptomsSymptoms of overdose include convulsions, spastic movements, and coma.
Carcinogen ClassificationNo indication of carcinogenicity to humans (not listed by IARC).
안전 데이터
- ridadr
- 3249
- HS 번호
- 2934.30.2700
- 포장분류
- III
- 위험 등급
- 6.1(b)
화학 및 산업
약리 정보
Metabolism/MetabolitesHepatic. Methotrimeprazine is metabolized in the liver and degraded to a sulfoxid-, a glucuronid- and a demethyl-moiety.
Half Life: Approximately 20 hours.
용도 및 제조
Uses
For the treatment of psychosis, particular those of schizophrenia, and manic phases of bipolar disorder. As a potentiator of anesthetics: In general anesthesia where it can be used as both a pre- and post-operative sedative and analgesic. (L1857) As an anti-emetic: For the treatment of nausea and vomiting of central origin.(L1857) As a sedative: For the management of insomnia. (L1857)
응용 분야
용도The (R) optical isomer of Methotrimeprazine (M260785), an analgesic/neuroleptic.
공급사35 곳
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