시나밀 안트라닐산

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

SMALL SPILLS AND LEAKAGE: Should a spill occur while you are handling this chemical, FIRST REMOVE ALL SOURCES OF IGNITION, then you should dampen the solid spill material with 60-70% ethanol and transfer the dampened material to a suitable container. Use absorbent paper dampened with 60-70% ethanol to pick up any remaining material. Seal the absorbent paper, and any of your clothes, which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with a combination filter cartridge, i.e. organic vapor/acid gas/HEPA (specific for organic vapors, HCl, acid gas, SO2 and a high efficiency particulate filter). (NTP, 1992)

The following link will take the user to the National Toxicology Program (NTP) Test Agent Search Results page, which tabulates all of the "Standard Toxicology & Carcinogenesis Studies", "Developmental Studies", and "Genetic Toxicity Studies" performed with this chemical. Clicking on the "Testing Status" link will take the user to the status (i.e., in review, in progress, in preparation, on test, completed, etc.) and results of all the studies that the NTP has done on this chemical. [http://ntp-apps.niehs.nih.gov/ntp_tox/index.cfm?fuseaction=ntpsearch.searchresults&searchterm=87-29-6]

Cinnamyl anthranilate

Group 3: Not classifiable as to its carcinogenicity to humans

Volume Sup 7: Overall Evaluations of Carcinogenicity: An Updating of IARC Monographs Volumes 1 to 42, 1987; 440 pages; ISBN 92-832-1411-0 (out of print)

2000

2000

Cinnamyl anthranilate

15 MALE & 15 FEMALE A/HE MICE...GIVEN IP...0.1 ML...IN TRICAPRYLIN THRICE WEEKLY FOR 8 WK (TOTAL...12 G/KG BODY WT). @ 24 WK...11 MALES & 10 FEMALES HAD LUNG TUMORS (2.7 & 2.1...TUMORS/MOUSE). OF 25 FEMALE CONTROLS INJECTED WITH TRICAPRYLIN ALONE...10 HAD LUNG TUMORS (0.59 LUNG TUMORS/MOUSE) (P GREATER THAN 0.05).

ALL OF 5 MICE SURVIVED 6 IP INJECTIONS OF 0.5 G/KG BODY WT GIVEN OVER 2-WK PERIOD.

FORTY-ONE FOOD ADDITIVES & TWENTY CHEMOTHERAPEUTIC AGENTS EXAMINED FOR THEIR ABILITY TO INDUCE PRIMARY LUNG TUMORS IN A MICE. ANIMALS ADMIN IP INJECTIONS OF EACH FOR 8 WK & KILLED @ 24 WK AFTER 1ST INJECTION. CINNAMYL ANTHRANILATE WAS ONLY POSITIVE OF 41 FOOD ADDITIVES TESTED.

... Under the conditions of this bioassay, cinnamyl anthranilate was carcinogenic for male and female B6C3F1 mice, inducing increased incidences of hepatocellular carcinomas or adenomas. The test chemical was also carcinogenic for male F344 rats, inducing low incidences of acinar cell carcinomas or adenomas of the pancreas and adenocarcinomas or adenomas of the adrenal cortex. Cinnamyl anthranilate was not carcinogenic for female F344 rats. Level of Evidence of Carcinogenicity: Male Rats: Positive; Female Rats: Negative; Male Mice: Positive; Female Mice: Positive.

A bioassay of cinnamyl anthranilate ... for possible carcinogenicity was conducted by administering the test chemical in feed to F344 rats and B6C3F1 mice. Groups of 50 rats and 50 mice of each sex were fed the test chemical in diets containing 15,000 or 30,000 ppm for 103 wk and then observed for an additional 2-3 wk. Controls consisted of 50 untreated rats and 50 untreated mice of each sex. All surviving animals were /sacrificed/ and necropsied at 105-107 wk. ... Under the conditions of this bioassay, cinnamyl anthranilate was carcinogenic for male and female B6C3F1 mice, inducing increased incidences of hepatocellular carcinomas or adenomas. The test chemical was also carcinogenic for male F344 rats, inducing low incidences of acinar cell carcinomas or adenomas of the pancreas and adenocarcinomas or adenomas of the adrenal cortex. Cinnamyl anthranilate was not carcinogenic for female F344 rats. Level of Evidence of Carcinogenicity: Male Rats: Positive; Female Rats: Negative; Male Mice: Positive; Female Mice: Positive.

1.3e-06

CALEPA

0.0046

CALEPA